Clinical trials on Corneal Ulcer

Understanding Corneal Ulcers

A corneal ulcer is a serious condition that can lead to significant vision impairment if not promptly treated. It is essentially an open sore that forms on the cornea, the clear, protective outer layer of the eye. This condition is most commonly caused by an infection due to bacteria, viruses, fungi, or parasites. Factors such as severe dry eyes, physical eye injury, or improper contact lens use can increase the risk of developing a corneal ulcer.

Symptoms and Treatment

Individuals with a corneal ulcer may experience a variety of symptoms, including severe pain, redness, blurred vision, sensitivity to light, and the sensation of having a foreign body in the eye. It is crucial for anyone experiencing these symptoms to seek immediate medical attention. Early diagnosis and treatment are key to preventing potential complications, such as scarring or vision loss.

Treatment for a corneal ulcer typically involves antibiotic, antifungal, or antiviral eye drops to combat the underlying infection. In more severe cases, oral medications or even corneal transplantation may be necessary. Additionally, measures to relieve symptoms, such as pain medication or eye patches, may be recommended. Preventative steps include practicing good contact lens hygiene, protecting the eyes from injury, and avoiding eye rubbing.

Prognosis for Corneal Ulcer

A corneal ulcer is an open sore on the cornea, the clear front surface of the eye. The long-term prospects for a corneal ulcer largely depend on the ulcer’s cause, size, location, and depth, as well as the promptness of treatment initiation. If detected early and managed effectively, there is a good prognosis with the potential for a full recovery of vision. However, severe or untreated ulcers may lead to complications that can result in scarring, vision impairment, or even loss of the eye. The healing process can vary from weeks to months, and in some cases, surgical intervention may be necessary to repair significant damage. Regular follow-up care is crucial to monitor healing and prevent recurrence. Overall, the prognosis is generally favorable when medical advice is sought promptly and followed diligently.

Complications in Corneal Ulcer

A corneal ulcer can lead to several complications that may significantly impact health and daily life. Should the ulcer worsen, it can cause the cornea to become deeply scarred, potentially resulting in blurred vision or even permanent vision loss. In severe cases, the ulcer may perforate the cornea, creating a hole that can cause serious eye infections and may lead to blindness. Chronic pain and discomfort are common as the sensitive cornea is affected. Additionally, the development of irregularities on the corneal surface can lead to astigmatism, where vision becomes distorted or blurry. These complications can hinder the ability to perform everyday tasks, such as reading or driving, and can dramatically reduce the overall quality of life. Awareness of these potential risks associated with a corneal ulcer is crucial.

Treatment Methods for Corneal Ulcer

For the management of a corneal ulcer, several non-clinical trial treatments are often recommended:

  • Dietary adjustments, such as the incorporation of foods rich in vitamins A and C, support eye health. Omega-3 fatty acids, found in fish and flaxseeds, may also be beneficial.
  • Regular physical activity improves overall health, which can contribute to a faster recovery.

Pharmacotherapy options include:

  • Antibiotic or antifungal eye drops, depending on the cause of the ulcer. These medications aim to eradicate the infection and promote healing.
  • In some instances, oral medications may be prescribed.

Modern technology offers treatments like:

  • Laser therapy, which can assist by removing the affected tissue and allowing healthy tissue to regenerate.
  • Another advanced option is corneal cross-linking, which strengthens corneal tissue to halt further damage.

It is advised to protect the eyes from irritants and to maintain good hygiene to prevent aggravation of the condition. Wearing sunglasses when outdoors can shield the eyes from harmful UV rays and reduce the risk of further injury.

  • CT-EU-00088910

    Testing a Wharton’s jelly extracts for chronic keratitis

    This clinical trial investigates the use of a specialized eye drop made of extract of umbilical cord lining constituted of Wharton’s jelly to treat chronic keratitis, an enduring eye condition that often manifests with symptoms like dryness, redness, and eye pain. Since conventional treatments have been ineffective, this study aims to evaluate the efficacy of this novel approach. During the trial, doctors will meticulously monitor these symptoms using a scoring system to assess their frequency and severity. They will also examine the skin around the eyes and monitor any changes in vision. Furthermore, they will employ a special dye called fluorescein to detect alterations in the eye’s surface and evaluate the patients’ visual acuity.

    • Wharton’s jelly extract/SygeLIX-Coll-T