Clinical trials on Aldosterone Disorder

  • CT-EU-00114408

    Understanding Skin’s Water and Electrolytes in Hypertension: The WHYSKI Study

    The Water and Electrolytes Content in HYpertension (WHYSKI) in the SKIn study is a research project that looks into how certain elements in your skin, like sodium (Na+), potassium (K+), and water, change in people who have a specific type of high blood pressure caused by a condition called primary aldosteronism. This condition can sometimes be treated with surgery. The study is interested in seeing if these skin changes can be reversed after the surgery.

    In this study, doctors will take a small piece of skin from patients before and, in some cases, after their surgery to measure the levels of Na+, K+, and water. They’re also interested in a special protein in your skin that might play a role in how your body handles these elements. This protein is called Tonicity Enhancing Binding Protein (TonEBP), and they’ll be looking at its levels too.

    The goal is to understand better how primary aldosteronism affects these elements in your skin and see if surgery can bring them back to normal levels. This could help doctors manage high blood pressure related to primary aldosteronism more effectively in the future.

    If you’re considering joining this study, you’ll be part of a group that includes people with primary aldosteronism, people with another type of high blood pressure, and people with normal blood pressure. This will help the researchers compare the results across different groups.

    This study is important because it’s exploring a new area that hasn’t been studied much before—the skin’s role in high blood pressure. By participating, you could help uncover new ways to treat this condition.