X-linked lymphoproliferative syndrome – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Thu, 28 May 2026 10:52:16 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png X-linked lymphoproliferative syndrome – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on Tadekinig Alfa for Patients with NLRC4 Mutation and XIAP Deficiency https://clinicaltrials.eu/trial/study-on-tadekinig-alfa-for-patients-with-nlrc4-mutation-and-xiap-deficiency/ Wed, 29 Apr 2026 14:23:59 +0000 https://clinicaltrials.eu/trial/study-on-tadekinig-alfa-for-patients-with-nlrc4-mutation-and-xiap-deficiency/ This clinical trial is focused on studying two rare genetic conditions known as NLRC4 mutation and XIAP deficiency. These are types of autoinflammatory diseases, which are conditions where the immune system mistakenly attacks the body, causing inflammation. The treatment being tested in this study is called Tadekinig alfa, also known by its code name rhIL-18BP. This medication is given as a solution for injection under the skin.

The purpose of this study is to monitor the long-term safety and tolerability of Tadekinig alfa in patients who have these specific genetic conditions. Patients participating in this study have previously been involved in an earlier clinical trial. This study is an open-label extension, meaning that all participants will receive the actual medication, and there is no placebo group. The study will observe how patients respond to the treatment over time, focusing on any side effects or adverse reactions they may experience.

Participants will receive regular injections of Tadekinig alfa and will be monitored by healthcare professionals throughout the study. The study aims to ensure that the treatment is safe and well-tolerated by patients with NLRC4 mutation and XIAP deficiency. The study will continue for a set period, during which patients will have regular check-ups to assess their health and any changes in their condition.

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