The medications used during the study include several types of antiemetic drugs, which are substances used to prevent or reduce vomiting and nausea. These medications include ondansetron, aprepitant, palonosetron, granisetron, and dexamethasone. Some of these medicines are taken by mouth, while others may be given through an intravenous line, which is a small tube inserted into a vein to deliver medicine directly into the bloodstream, or via subcutaneous injection, which means the medicine is injected just under the skin.

During the course of the study, participants will be assigned to different groups to receive either the new medication or a placebo alongside their current anti-nausea treatments. The different groups will be monitored to see how many people experience a complete response, meaning they have no vomiting and do not need to take extra rescue medicine to manage their symptoms.