Vitamin D deficiency – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:24:58 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Vitamin D deficiency – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 High-Dose Colecalciferol for 28-Day Mortality in Critically Ill Adults with Severe Vitamin D Deficiency https://clinicaltrials.eu/trial/study-to-evaluate-the-effect-of-colecalciferol-on-survival-in-critically-ill-adults-with-severe-vitamin-d-deficiency/ Thu, 07 May 2026 05:47:14 +0000 https://clinicaltrials.eu/trial/study-to-evaluate-the-effect-of-colecalciferol-on-survival-in-critically-ill-adults-with-severe-vitamin-d-deficiency/ This clinical trial is studying adult critically ill patients with severe vitamin D deficiency, a condition in which the body has very low levels of vitamin D and the person is seriously unwell. The study is testing colecalciferol, a form of vitamin D3, given as oral drops, and comparing it with placebo. The purpose of the study is to find out whether a high dose of vitamin D3 can improve recovery and reduce the chance of death in the first 28 days after treatment.

In this study, people receive either the vitamin D3 drops or placebo, and the care team follows their progress over time. The study looks at what happens during the hospital stay and after discharge, including survival, time in intensive care, time in the hospital, and later health problems such as infections, falls, fractures, and kidney stones. It also checks for possible side effects of high vitamin D, such as hypercalcemia, which means too much calcium in the blood.

]]> Study on High-Dose Vitamin D3 and Glycerol for Improving Wound Healing After Wisdom Tooth Removal in Patients with Vitamin D Insufficiency https://clinicaltrials.eu/trial/study-on-high-dose-vitamin-d3-and-glycerol-for-improving-wound-healing-after-wisdom-tooth-removal-in-patients-with-vitamin-d-insufficiency/ Wed, 29 Apr 2026 15:02:31 +0000 https://clinicaltrials.eu/trial/study-on-high-dose-vitamin-d3-and-glycerol-for-improving-wound-healing-after-wisdom-tooth-removal-in-patients-with-vitamin-d-insufficiency/ This clinical trial is focused on studying the effects of high-dose Vitamin D3 supplementation on the healing of soft tissue wounds after the removal of wisdom teeth, also known as third molars. The study is particularly interested in individuals who have Vitamin D insufficiency and are undergoing tooth extraction. The treatment being tested involves the use of colecalciferol, which is another name for Vitamin D3, combined with glycerol. Participants will receive this treatment to see if it helps improve the healing process after their wisdom teeth are removed.

The purpose of the study is to investigate how short-term, high-dose Vitamin D3 supplementation might influence the healing of soft tissues after wisdom tooth extraction. Participants will be given Vitamin D3 supplements and their healing process will be monitored. The study will compare the healing of the first extracted wisdom tooth without Vitamin D3 intervention to the second extracted wisdom tooth with Vitamin D3 intervention. This will help researchers understand if Vitamin D3 can make a difference in the healing process.

Throughout the study, researchers will also measure certain substances in saliva and blood to see how they change with and without Vitamin D3 supplementation. These substances include interleukin (IL)-1b, IL-8, and myeloid-related protein (MRP)-8/14, which are involved in the body’s inflammatory response. The study aims to provide insights into whether Vitamin D3 can help reduce inflammation and improve healing after wisdom tooth extraction.

]]> Study on the Effectiveness of Cholecalciferol and Calcifediol in Treating Severe Vitamin D Deficiency in Patients https://clinicaltrials.eu/trial/study-on-the-effectiveness-of-cholecalciferol-and-calcifediol-in-treating-severe-vitamin-d-deficiency-in-patients/ Wed, 29 Apr 2026 15:01:06 +0000 https://clinicaltrials.eu/trial/study-on-the-effectiveness-of-cholecalciferol-and-calcifediol-in-treating-severe-vitamin-d-deficiency-in-patients/ This clinical trial is focused on studying the treatment of severe vitamin D deficiency, a condition where the body has very low levels of vitamin D, which is essential for maintaining healthy bones and immune function. The study will compare two treatments: cholecalciferol (also known as vitamin D3) and calcifediol. Cholecalciferol is a form of vitamin D that is commonly used to increase vitamin D levels in the body, while calcifediol is a different form of vitamin D that is sometimes used for the same purpose.

The purpose of the study is to evaluate how effective and safe these treatments are in correcting vitamin D deficiency. Participants will be randomly assigned to receive either cholecalciferol or calcifediol. The study will last for a total of 12 weeks, with the main focus on the first 6 weeks. During this time, participants will take the assigned treatment orally, and their vitamin D levels will be monitored to see if they reach a healthy level. The study will also look at how well participants stick to the treatment plan and their satisfaction with the treatment.

Throughout the study, the safety of the treatments will be closely monitored by checking for any side effects. The goal is to determine which treatment is more effective in raising vitamin D levels to a healthy range and to ensure that the treatments are safe for participants. This information could help improve the management of severe vitamin D deficiency in the future.

]]> Comparison of Two Vitamin D3 Doses (500,000 IU vs 750,000 IU) in Critically Ill Patients with Vitamin D Deficiency Receiving Continuous Renal Replacement Therapy https://clinicaltrials.eu/trial/study-on-the-effects-of-two-doses-of-vitamin-d3-colecalciferol-in-icu-patients-with-severe-vitamin-d-deficiency-undergoing-continuous-renal-replacement-therapy/ Wed, 29 Apr 2026 15:00:50 +0000 https://clinicaltrials.eu/trial/study-on-the-effects-of-two-doses-of-vitamin-d3-colecalciferol-in-icu-patients-with-severe-vitamin-d-deficiency-undergoing-continuous-renal-replacement-therapy/ This study focuses on patients with severe Vitamin D3 deficiency who are critically ill and receiving continuous renal replacement therapy (a treatment that helps filter waste from the blood when the kidneys are not working properly). The study compares two different doses of vitamin D3 (also known as colecalciferol) given as oral drops through a feeding tube or by mouth to these patients.

The purpose of this research is to determine how effectively two different doses of vitamin D3 (500,000 IU and 750,000 IU) can increase vitamin D levels in the blood. The medication being used is Devikap, which comes as an oral solution in the form of drops. Patients will receive a single dose of the medication and will be monitored for several days afterward.

During the study, doctors will check vitamin D levels in the blood and monitor various aspects of patient health. The study will track how patients respond to the treatment, including their recovery progress and any changes in their condition. This research is particularly important for critically ill patients who often have very low vitamin D levels while receiving kidney support treatment.

]]> Study on the Required Dose of Cholecalciferol for Managing Vitamin D Deficiency in Postmenopausal Women https://clinicaltrials.eu/trial/study-on-the-required-dose-of-cholecalciferol-for-managing-vitamin-d-deficiency-in-postmenopausal-women/ Wed, 29 Apr 2026 14:24:02 +0000 https://clinicaltrials.eu/trial/study-on-the-required-dose-of-cholecalciferol-for-managing-vitamin-d-deficiency-in-postmenopausal-women/ This clinical trial is focused on studying the effects of a treatment for vitamin D deficiency and insufficiency in postmenopausal women. The treatment being tested is a medication called Cholecalciferol, which is a form of vitamin D. The purpose of the study is to determine the required dose of Cholecalciferol to effectively manage vitamin D levels in women who have gone through menopause and are experiencing low levels of this important vitamin.

Participants in the study will take Cholecalciferol in the form of soft capsules, known as Lundeos 20,000 UI. The study will involve several visits where vitamin D levels in the blood will be measured to see how well the treatment is working. The study will also look at how satisfied participants are with the treatment. The treatment is taken orally, which means it is swallowed like a regular pill.

The study will help to understand how much Cholecalciferol is needed to maintain healthy vitamin D levels in postmenopausal women. This is important because vitamin D plays a crucial role in bone health and overall well-being. By participating in this study, researchers hope to find the best way to support women who are experiencing vitamin D deficiency or insufficiency after menopause.

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