Vitamin B12 deficiency – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Tue, 02 Jun 2026 12:26:13 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Vitamin B12 deficiency – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study of High-Dose Hydroxocobalamin for Patients with Cobalamin Deficiency https://clinicaltrials.eu/trial/study-of-high-dose-hydroxocobalamin-for-patients-with-cobalamin-deficiency/ Wed, 29 Apr 2026 15:05:14 +0000 https://clinicaltrials.eu/trial/study-of-high-dose-hydroxocobalamin-for-patients-with-cobalamin-deficiency/ This clinical trial is focused on studying a group of conditions known as cobalamin-related remethylation disorders. These disorders are linked to a deficiency in a vitamin called hydroxycobalamin, which is a form of vitamin B12. The study will use a treatment involving high doses of hydroxycobalamin, administered as a solution for injection, to see if it can effectively lower the levels of a substance in the blood called tHcy, which stands for total homocysteine. High levels of tHcy are often found in individuals with these disorders.

The purpose of the study is to determine if high doses of hydroxycobalamin are more effective than standard doses in reducing tHcy levels. Participants in the study will receive injections of hydroxycobalamin and will have their blood tHcy levels measured at various intervals over a period of 24 months. These intervals include baseline measurements and follow-ups at 3, 6, 9, 12, 15, 18, and 24 months. The study aims to compare the effectiveness of the high-dose treatment with the standard-dose treatment.

This study is particularly focused on pediatric patients under 2 years of age who have been diagnosed with any of the cobalamin-related remethylation disorders and show early signs of the condition, such as eye problems. The study will involve regular monitoring to ensure the safety and effectiveness of the treatment over the course of the trial.

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