Ventricular fibrillation – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:13:58 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Ventricular fibrillation – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on the Effect of Landiolol Hydrochloride and Sodium Chloride in Patients Experiencing Cardiac Arrest https://clinicaltrials.eu/trial/study-on-the-effect-of-landiolol-hydrochloride-and-sodium-chloride-in-patients-experiencing-cardiac-arrest/ Wed, 29 Apr 2026 15:02:32 +0000 https://clinicaltrials.eu/trial/study-on-the-effect-of-landiolol-hydrochloride-and-sodium-chloride-in-patients-experiencing-cardiac-arrest/ This clinical trial is focused on studying the effects of a treatment for patients who have experienced a cardiac arrest, specifically those with a type of irregular heart rhythm known as ventricular fibrillation. The treatment being tested is a medication called landiolol hydrochloride, which is a type of drug known as a beta-blocker. Beta-blockers are commonly used to manage heart conditions by slowing down the heart rate and reducing blood pressure. In this study, landiolol hydrochloride is being compared to a placebo to see if it can help improve the chances of the heart starting to beat on its own again after a cardiac arrest.

The purpose of the study is to find out if adding landiolol hydrochloride to the standard treatment for cardiac arrest can decrease the time it takes for the heart to achieve a sustained return of spontaneous circulation (sROSC), which means the heart starts beating effectively on its own. Participants in the study will receive either the landiolol hydrochloride or a placebo through an intravenous injection, which means the medication is given directly into a vein. The study will monitor how quickly the heart starts beating again and will also look at other outcomes, such as survival after 24 hours and the patient’s neurological condition.

In addition to landiolol hydrochloride, the study involves the use of sodium chloride solution, which is a common fluid used in medical settings to help deliver medications intravenously. The study is designed to be double-blind, meaning neither the participants nor the researchers know who is receiving the actual medication or the placebo, ensuring unbiased results. The trial aims to provide valuable information on whether landiolol hydrochloride can be an effective addition to the treatment of cardiac arrest, potentially improving outcomes for patients experiencing this life-threatening condition.

]]> Study Comparing Quinidine and Verapamil for Patients with Short-Coupled Idiopathic Ventricular Fibrillation https://clinicaltrials.eu/trial/study-comparing-quinidine-and-verapamil-for-patients-with-short-coupled-idiopathic-ventricular-fibrillation/ Wed, 29 Apr 2026 14:56:51 +0000 https://clinicaltrials.eu/trial/study-comparing-quinidine-and-verapamil-for-patients-with-short-coupled-idiopathic-ventricular-fibrillation/ This clinical trial is focused on studying a heart condition known as Short-coupled Idiopathic Ventricular Fibrillation (IVF). This condition involves irregular heartbeats that can lead to serious heart rhythm problems. The study is comparing two medications, Quinidine and Verapamil, to see which one is more effective and safe for treating this condition. Both medications are taken orally, meaning they are swallowed in pill form.

The purpose of the study is to determine if a larger, more definitive trial is advisable and feasible. Participants in the study will receive both medications at different times. This is known as a crossover study, where each participant tries both treatments. The study will last for a period of 18 months, during which participants will be monitored for any changes in their heart rhythm and any side effects they might experience.

Throughout the study, the main focus will be on observing any sustained irregular heartbeats, known as ventricular arrhythmias, which are serious heart rhythm disturbances. The results will help researchers understand which medication might be better for managing this heart condition in the future.

]]> Study on the Effects of Bisoprolol Fumarate, Hydrochlorothiazide, and Metoprolol in Patients with Idiopathic Ventricular Fibrillation After Cardiac Arrest https://clinicaltrials.eu/trial/study-on-the-effects-of-bisoprolol-fumarate-hydrochlorothiazide-and-metoprolol-in-patients-with-idiopathic-ventricular-fibrillation-after-cardiac-arrest/ Wed, 29 Apr 2026 14:22:46 +0000 https://clinicaltrials.eu/trial/study-on-the-effects-of-bisoprolol-fumarate-hydrochlorothiazide-and-metoprolol-in-patients-with-idiopathic-ventricular-fibrillation-after-cardiac-arrest/ This clinical trial is focused on studying patients who have experienced an unexplained cardiac arrest, a condition where the heart suddenly stops beating without a known cause. Specifically, the study looks at a type of cardiac arrest known as Idiopathic Ventricular Fibrillation (IVF). The purpose of the study is to investigate the effects of different beta-blocker treatments on these patients. Beta-blockers are medications that help manage heart conditions by slowing down the heart rate and reducing blood pressure.

The medications being studied include Bisoprolol Fumarate, Hydrochlorothiazide, Metoprolol, Atenolol, Chlortalidone, Nadolol, and Propranolol Hydrochloride. These medications are taken orally, meaning they are swallowed in pill form. The study will compare the effects of these medications to see which is most effective in preventing further heart issues in patients with IVF.

Participants in the study will receive one of these medications or a placebo for up to 36 months. Throughout the study, patients will have regular check-ups to monitor their heart health and any changes in their condition. The study will also assess the quality of life of participants after one year. The goal is to determine which treatment is most beneficial for patients who have survived an unexplained cardiac arrest.

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