Uterine leiomyoma – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Thu, 28 May 2026 11:26:42 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Uterine leiomyoma – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on Reducing Bleeding Risk in Fibroid Surgery Using Misoprostol for Patients Undergoing Myomectomy https://clinicaltrials.eu/trial/study-on-reducing-bleeding-risk-in-fibroid-surgery-using-misoprostol-for-patients-undergoing-myomectomy/ Wed, 29 Apr 2026 15:03:32 +0000 https://clinicaltrials.eu/trial/study-on-reducing-bleeding-risk-in-fibroid-surgery-using-misoprostol-for-patients-undergoing-myomectomy/ This clinical trial is focused on studying the effects of a medication called Misoprostol in patients undergoing surgery for fibroids, which are non-cancerous growths in the uterus. The study aims to see if Misoprostol can help reduce blood loss during these surgeries. Participants in the study will be divided into two groups: one group will receive Misoprostol, and the other group will receive a placebo, which looks like the medication but does not contain any active ingredients.

The purpose of the study is to evaluate how Misoprostol affects blood loss during the surgical removal of fibroids, known as a myomectomy. Participants will take the medication or placebo before their surgery, and researchers will measure the amount of blood lost during the procedure. The study will also look at other factors, such as changes in hemoglobin levels, which is a protein in red blood cells that carries oxygen, and the length of hospital stay after surgery.

Throughout the study, researchers will compare the results between the group taking Misoprostol and the group taking the placebo. This will help determine if Misoprostol is effective in reducing blood loss and improving outcomes for patients undergoing myomectomy for fibroids. The study is expected to continue until December 2026, with recruitment starting in October 2024.

]]> Study Comparing Ulipristal Acetate and Surgery for Women with Symptomatic Uterine Fibroids https://clinicaltrials.eu/trial/study-comparing-ulipristal-acetate-and-surgery-for-women-with-symptomatic-uterine-fibroids/ Wed, 29 Apr 2026 15:02:09 +0000 https://clinicaltrials.eu/trial/study-comparing-ulipristal-acetate-and-surgery-for-women-with-symptomatic-uterine-fibroids/ This clinical trial is focused on studying the effects of a medication called ulipristal acetate, which is available in the form of Esmya 5 mg tablets. The study is comparing this medication to standard surgical treatments for a condition known as uterine fibroids. Uterine fibroids are non-cancerous growths that develop in or on the uterus, often causing symptoms such as heavy menstrual bleeding, pain, and pressure in the pelvic area.

The purpose of the study is to evaluate how well ulipristal acetate improves the quality of life for women with symptomatic uterine fibroids compared to those who undergo surgery. Participants in the study will be randomly assigned to receive either the medication or a surgical treatment. The study will follow participants for a period of 24 months to assess changes in symptoms and overall quality of life. The study will also look at the costs associated with each treatment, including healthcare expenses and any impact on work productivity.

Throughout the study, researchers will monitor various aspects of health and well-being, such as pain levels, social participation, and sexual functioning. They will also track any changes in fibroid size, menstrual bleeding, and blood health, including liver function. The study aims to understand which treatment option is more effective and satisfactory for patients, as well as to identify any side effects or complications. The findings will help determine the best approach for managing uterine fibroids and improving patients’ lives.

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