Urinary tract infection bacterial – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Thu, 28 May 2026 11:32:59 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Urinary tract infection bacterial – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Short-course (7‑day) versus standard 14‑day ciprofloxacin treatment for men with serious urinary tract infection https://clinicaltrials.eu/trial/short-course-7-day-versus-standard-14-day-ciprofloxacin-treatment-for-men-with-serious-urinary-tract-infection/ Wed, 13 May 2026 05:05:05 +0000 https://clinicaltrials.eu/trial/short-course-7-day-versus-standard-14-day-ciprofloxacin-treatment-for-men-with-serious-urinary-tract-infection/ A Urinary tract infection that spreads beyond the bladder and causes fever, flank pain, low blood pressure, or high levels of inflammation in the blood is being studied. The infection is treated with the oral antibiotic ciprofloxacin, which is taken as a tablet. In some cases a matching placebo capsule that looks the same as the antibiotic may be used to keep the study blinded.

The purpose of the study is to determine whether a shorter, 7‑day course of the antibiotic works as well as the standard 14‑day course in achieving a cure of the infection.

Participants are randomly assigned to receive either the short or the longer treatment. After finishing the medication, they are followed up with visits about two weeks and four weeks later to check whether symptoms have resolved, whether the infection has returned, and whether any side effects have occurred. “Clinical cure” means the patient’s signs and symptoms have returned to normal and no additional antibiotics are needed.

]]> Study of Pivmecillinam and Amoxicillin/Clavulanic Acid for Treating Urinary Tract Infections in Patients with Multidrug-Resistant Bacteria https://clinicaltrials.eu/trial/study-of-pivmecillinam-and-amoxicillin-clavulanic-acid-for-treating-urinary-tract-infections-in-patients-with-multidrug-resistant-bacteria/ Wed, 29 Apr 2026 14:22:35 +0000 https://clinicaltrials.eu/trial/study-of-pivmecillinam-and-amoxicillin-clavulanic-acid-for-treating-urinary-tract-infections-in-patients-with-multidrug-resistant-bacteria/ This clinical trial is focused on finding effective treatments for urinary tract infections (UTIs) and bacteremia caused by bacteria known as extended spectrum beta-lactamases (ESBL)-producing Enterobacterales. These bacteria are resistant to many common antibiotics, making infections difficult to treat. The study will explore the use of different antibiotics to see if they can be effective alternatives to the usual treatments. The antibiotics being studied include Amoxicillin/Clavulanic acid, Ciprofloxacin, Sulfamethoxazole/Trimethoprim, Ertapenem, and Pivmecillinam.

The purpose of the study is to determine if these alternative antibiotics can safely and effectively treat febrile UTIs, which are UTIs accompanied by fever, caused by ESBL-producing bacteria. Participants in the study will initially receive intravenous antibiotics for a few days. Once their condition is stable, they will switch to oral antibiotics. The study will monitor the participants’ health to ensure the infection is resolved and no further antibiotic treatment is needed.

Throughout the study, participants will be observed for any signs of the infection returning and for any side effects from the antibiotics. The study will also check if the bacteria are still present in urine or stool samples after treatment. The goal is to find a reliable oral antibiotic treatment that can be used instead of the more commonly used antibiotics, which may not be effective against these resistant bacteria. The study will help doctors understand which antibiotics can be safely used to treat these challenging infections.

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