Urethral valves – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:16:24 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Urethral valves – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on the Effectiveness and Safety of Circumcision and Antibiotic Treatment (Cefaclor, Sulfamethoxazole, Trimethoprim) for Boys with Posterior Urethral Valves https://clinicaltrials.eu/trial/study-on-the-effectiveness-and-safety-of-circumcision-and-antibiotic-treatment-cefaclor-sulfamethoxazole-trimethoprim-for-boys-with-posterior-urethral-valves/ Wed, 29 Apr 2026 15:05:12 +0000 https://clinicaltrials.eu/trial/study-on-the-effectiveness-and-safety-of-circumcision-and-antibiotic-treatment-cefaclor-sulfamethoxazole-trimethoprim-for-boys-with-posterior-urethral-valves/ This clinical trial is focused on studying the effects of circumcision on the risk of febrile urinary tract infections (fUTIs) in boys with a condition called Posterior Urethral Valves (PUV). PUV is a blockage in the urinary tract that occurs in boys and can lead to urinary problems. The study aims to understand how circumcision alone, as well as in combination with antibiotic treatments, affects the likelihood of developing fUTIs over a period of two years.

In this study, the medications being used include ALFATIL, which contains the active substance cefaclor, Bactrim, which contains sulfamethoxazole and trimethoprim, and AUGMENTIN, which contains amoxicillin and clavulanic acid. These medications are all antibiotics, which are drugs used to treat bacterial infections. The trial will compare the effects of circumcision alone, circumcision with antibiotics, and antibiotics alone on the risk of fUTIs.

The study will follow participants over a two-year period to observe the time it takes for the first fUTI to occur, if at all. It will also look at the number of infections, any changes in kidney health, and the types of bacteria causing the infections. The goal is to determine the best approach to reduce the risk of fUTIs in boys with PUV, using historical data to enrich the findings. Participants will be monitored for their adherence to the antibiotic treatments and the overall effectiveness of the different approaches will be assessed.

]]> Study on Early Oxybutynin Treatment for Boys with Posterior Urethral Valves https://clinicaltrials.eu/trial/study-on-early-oxybutynin-treatment-for-boys-with-posterior-urethral-valves/ Wed, 29 Apr 2026 14:58:48 +0000 https://clinicaltrials.eu/trial/study-on-early-oxybutynin-treatment-for-boys-with-posterior-urethral-valves/ This clinical trial is focused on studying a condition known as posterior urethral valves, which affects the urinary tract in boys. The trial is investigating the effects of a treatment using a medication called oxybutynin, which is administered in the form of a syrup. Oxybutynin is known for its properties as an anticholinergic and antispasmodic, meaning it helps to relax the bladder muscles and reduce spasms.

The purpose of the study is to understand how early treatment with oxybutynin can influence bladder function in boys who have undergone surgery to remove the posterior urethral valves. The study will observe changes in bladder compliance, which refers to how well the bladder can stretch and hold urine, as well as bladder volume and the pressure during urination. Boys participating in the study will receive the treatment for a period of up to nine months.

Throughout the study, researchers will monitor various aspects of the boys’ health, including any side effects from the treatment and the occurrence of urinary tract infections. The study will also involve regular check-ups to assess the condition of the kidneys using ultrasound, a method that uses sound waves to create images of the inside of the body. Additionally, the study will look at how the body processes oxybutynin by measuring its levels in the blood at different times. This will help to understand how the medication is absorbed and broken down in the body. The study aims to provide valuable insights into the management of posterior urethral valves in young boys.

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