Ureteric cancer – European Clinical Trials Information Network

Study on the Safety and Effectiveness of Padeliporfin Therapy for Patients with Low-Grade Upper Tract Urothelial Cancer

Wed, 29 Apr 2026 14:29:24 +0000

This clinical trial is focused on studying a type of cancer called Low-Grade Upper Tract Urothelial Cancer (UTUC). This cancer affects the lining of the urinary system, specifically in areas like the kidney and ureter. The study is testing a treatment called TOOKAD (padeliporfin), which is a special therapy known as Vascular Targeted Photodynamic Therapy (VTP). This treatment involves using a drug that is activated by light to target and treat the cancer cells.

The purpose of the study is to evaluate how safe and effective TOOKAD is in treating this type of cancer. Participants in the study will receive the treatment through an intravenous infusion, which means the drug is given directly into a vein. The drug is then activated by a laser light delivery system, which helps to target the cancer cells more precisely. The study will monitor the participants over a period of time to see how well the treatment works and to check for any side effects.

Throughout the study, researchers will look for the absence of cancer in the treated areas, such as the kidney and ureter, using methods like endoscopy, which is a procedure that allows doctors to look inside the body. The study will also assess the overall health of the kidney and whether the treatment helps in preserving kidney function. Safety follow-ups will be conducted to record any adverse events experienced by the participants. The study aims to provide valuable information on the effectiveness and safety of TOOKAD in treating Low-Grade Upper Tract Urothelial Cancer.

Study on Spinal Morphine, Intravenous Lidocaine, and Bupivacaine for Patients Undergoing Robot-Assisted Surgery for Kidney or Ureter Conditions

Wed, 29 Apr 2026 14:26:24 +0000

This clinical trial is focused on improving recovery after surgery for patients undergoing robot-assisted upper urinary tract surgery, which is a type of surgery involving the kidneys or ureters. The study is particularly interested in conditions such as renal cancer, ureter cancer, benign kidney tumors, kidney stones, and kidney reflux. The trial will explore the effects of different pain management strategies during and after surgery.

Participants in the study will receive one of the following treatments: spinal morphine, which is derived from the opium poppy and administered directly into the spinal fluid, or intravenous lidocaine, a common local anesthetic given through a vein. Additionally, some patients will receive a combination of bupivacaine, another local anesthetic, and adrenaline, which helps prolong the effects of the anesthetic. The purpose of the study is to determine if these treatments can enhance recovery after surgery, as measured by a patient-centered outcome scale called “Quality of Recovery 15.”

The study will involve a random assignment of treatments to participants, and it will be conducted without the participants knowing which treatment they are receiving. The trial will monitor recovery progress, including pain levels and overall well-being, at various points after surgery. The goal is to find the most effective pain management strategy to improve the recovery experience for patients undergoing this type of surgery.