Turner’s syndrome – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 19 Jun 2026 04:03:03 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Turner’s syndrome – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on Long-Term Effects of Oral and Transdermal Estradiol Therapy in Women with Turner Syndrome https://clinicaltrials.eu/trial/study-on-long-term-effects-of-oral-and-transdermal-estradiol-therapy-in-women-with-turner-syndrome/ Wed, 29 Apr 2026 15:05:53 +0000 https://clinicaltrials.eu/trial/study-on-long-term-effects-of-oral-and-transdermal-estradiol-therapy-in-women-with-turner-syndrome/ This clinical trial is focused on studying the effects of estrogen replacement therapy in women with Turner syndrome. Turner syndrome is a condition that affects females, where one of the X chromosomes is missing or partially missing, leading to various developmental issues. The study will compare two forms of estrogen therapy: an oral tablet called Estrofem and a transdermal gel known as Divigel. Both treatments contain the active substance estradiol, which is a form of estrogen, a hormone important for female development and health.

The purpose of the study is to understand the long-term effects of these two types of estrogen therapy on various health aspects in women with Turner syndrome. Participants will receive either the oral or transdermal form of estrogen therapy. The study will look at how these treatments affect different areas such as hormone levels, heart health, and overall physical well-being. The study will also assess the risk factors related to blood clots and other cardiovascular issues.

Throughout the study, participants will undergo various tests to monitor changes in their body composition, blood values, heart function, muscle strength, and bone density. Additionally, participants will be asked to report on their quality of life and how they feel about the treatments after six months of using each form of therapy. The study aims to provide valuable insights into the best ways to manage Turner syndrome with estrogen therapy.

]]> Study on Testosterone and Isopropyl Myristate for Women with Turner Syndrome https://clinicaltrials.eu/trial/study-on-testosterone-and-isopropyl-myristate-for-women-with-turner-syndrome/ Wed, 29 Apr 2026 15:04:31 +0000 https://clinicaltrials.eu/trial/study-on-testosterone-and-isopropyl-myristate-for-women-with-turner-syndrome/ This clinical trial is focused on studying the effects of Testosterone Replacement Therapy (TRT) in women with Turner Syndrome. Turner Syndrome is a condition that affects females, where one of the X chromosomes is missing or partially missing, leading to various developmental issues. The study aims to understand how TRT, when used alongside estrogen replacement therapy, impacts different aspects of health, including hormone levels, heart health, brain function, and overall physical well-being.

The treatment being tested is a transdermal gel called Androgel, which contains testosterone. This gel is applied to the skin, allowing the testosterone to be absorbed into the body. The study will also involve other substances like Isopropyl Myristate, Carbomer 980, Sodium Hydroxide, and Ethanol (96 per cent), which are used in the formulation of the gel. Some participants will receive a placebo to compare the effects of the actual treatment.

Participants in the study will use the treatment for up to 12 months. Throughout the study, various health parameters will be monitored, such as body composition, quality of life, and physical activity levels. The goal is to gather comprehensive data on how TRT affects women with Turner Syndrome, providing insights into its potential benefits and any side effects. This research could help improve treatment options for women with this condition in the future.

]]> Study of Vosoritide for Children with Turner Syndrome, Short Stature Homeobox-Containing Gene Deficiency, and Noonan Syndrome Not Responding to Growth Hormone https://clinicaltrials.eu/trial/study-of-vosoritide-for-children-with-turner-syndrome-short-stature-homeobox-containing-gene-deficiency-and-noonan-syndrome-not-responding-to-growth-hormone/ Wed, 29 Apr 2026 15:03:11 +0000 https://clinicaltrials.eu/trial/study-of-vosoritide-for-children-with-turner-syndrome-short-stature-homeobox-containing-gene-deficiency-and-noonan-syndrome-not-responding-to-growth-hormone/ This clinical trial is focused on studying the effects of a treatment called vosoritide in children with certain growth-related conditions. These conditions include Turner Syndrome, Short Stature Homeobox-Containing Gene Deficiency, and Noonan Syndrome. These are genetic conditions that can affect growth and development in children. The study will compare the effects of vosoritide with those of continued treatment with human growth hormone (hGH), which is a common treatment for these conditions.

The purpose of the study is to evaluate how different doses of vosoritide affect growth in children who have not responded adequately to hGH. The study will involve children who have been receiving hGH for at least a year. Participants will be randomly assigned to receive either vosoritide or continue with hGH. The study will last for several months, during which the growth of the children will be monitored and compared.

Throughout the study, researchers will observe changes in growth and monitor for any side effects. The study aims to provide insights into whether vosoritide can be an effective alternative or addition to hGH for improving growth in children with these specific conditions. The study will also track other health indicators to ensure the safety and effectiveness of the treatment. The results will help determine if vosoritide can be a beneficial treatment option for children with these growth challenges.

]]> Study Comparing Somapacitan and Somatropin for Growth in Children with Short Stature Due to Small for Gestational Age, Turner Syndrome, Noonan Syndrome, or Idiopathic Short Stature https://clinicaltrials.eu/trial/study-comparing-somapacitan-and-somatropin-for-growth-in-children-with-short-stature-due-to-small-for-gestational-age-turner-syndrome-noonan-syndrome-or-idiopathic-short-stature/ Wed, 29 Apr 2026 14:27:17 +0000 https://clinicaltrials.eu/trial/study-comparing-somapacitan-and-somatropin-for-growth-in-children-with-short-stature-due-to-small-for-gestational-age-turner-syndrome-noonan-syndrome-or-idiopathic-short-stature/ This clinical trial is focused on children with short stature, which means they are shorter than most children their age. The study includes children who were either born small for their age, or have conditions like Turner syndrome, Noonan syndrome, or idiopathic short stature, which means the cause of their short stature is unknown. The trial is testing a new treatment called somapacitan, which is given once a week, and comparing it to a daily treatment called Norditropin®. Both treatments are designed to help children grow taller.

The purpose of the study is to see if the once-weekly somapacitan is as effective as the daily Norditropin® in helping children grow. The study will last for a period of time, during which children will receive either somapacitan or Norditropin®. The somapacitan is administered using a special pen-injector called the PDS290 pen-injector, which is a pre-filled device that makes it easier to give the injection. The study will monitor the children’s growth over time, specifically looking at how fast they grow in height.

Throughout the study, researchers will also keep an eye on the long-term safety of somapacitan. They will measure various health indicators, such as changes in bone age and levels of certain substances in the blood, like IGF-I and IGFBP-3, which are related to growth. The study aims to provide valuable information on whether somapacitan can be a safe and effective option for children with short stature conditions.

]]> Study on the Safety and Effectiveness of Somapacitan for Children with Short Stature Due to Noonan Syndrome, Turner Syndrome, Small for Gestational Age, or Idiopathic Short Stature https://clinicaltrials.eu/trial/study-on-the-safety-and-effectiveness-of-somapacitan-for-children-with-short-stature-due-to-noonan-syndrome-turner-syndrome-small-for-gestational-age-or-idiopathic-short-stature/ Wed, 29 Apr 2026 14:24:41 +0000 https://clinicaltrials.eu/trial/study-on-the-safety-and-effectiveness-of-somapacitan-for-children-with-short-stature-due-to-noonan-syndrome-turner-syndrome-small-for-gestational-age-or-idiopathic-short-stature/ This clinical trial is focused on studying the safety and effectiveness of a medication called Somapacitan in children who have difficulty growing. The study includes children with conditions such as Turner syndrome, Noonan syndrome, being born small for gestational age, or having idiopathic short stature, which means short stature without a known cause. Somapacitan is given as a solution for injection under the skin, using a special pen-injector designed for single patient use.

The purpose of the study is to evaluate how safe Somapacitan is and how well it works in helping children grow. Participants in the study will receive the medication once a week. The study will monitor the number of any adverse events, which are unexpected medical problems, over a period of time. The study will also look at how the children’s height changes during the study.

The study will take place over several weeks, with regular check-ups to monitor the children’s growth and any side effects they might experience. The goal is to gather information on how Somapacitan affects growth in children with these specific conditions, providing valuable insights into its potential benefits and safety.

]]> Study on Estrogen Treatment (Oral vs. Transdermal) for Women with Turner Syndrome https://clinicaltrials.eu/trial/study-on-estrogen-treatment-oral-vs-transdermal-for-women-with-turner-syndrome/ Wed, 29 Apr 2026 14:22:45 +0000 https://clinicaltrials.eu/trial/study-on-estrogen-treatment-oral-vs-transdermal-for-women-with-turner-syndrome/ This clinical trial focuses on studying Turner syndrome, a condition that affects females and is characterized by the absence of all or part of a second sex chromosome. The study aims to compare the effectiveness of two different forms of estradiol treatment, which is a type of estrogen hormone therapy. The treatments being compared are Estrofem, a film-coated tablet taken orally, and Divigel, a gel applied to the skin. Both treatments contain the active substance estradiol, which is used to help manage symptoms associated with Turner syndrome.

The purpose of the study is to determine if the oral and transdermal (through the skin) forms of estradiol are equally effective in treating women with Turner syndrome. Participants in the study will receive either the oral or transdermal treatment and will be monitored for changes in hormone levels, specifically luteinizing hormone and follicle-stimulating hormone, which are important indicators of how the body is responding to the treatment. The study will help researchers understand if both forms of treatment provide the same benefits.

Participants will be involved in the study for a period of up to 14 days, during which they will receive one of the two treatments. The study will not only help in understanding the effectiveness of these treatments but also provide insights into the best way to manage Turner syndrome using hormone therapy. The findings from this study could lead to improved treatment options for women with this condition.

]]> Turner Syndrome Support Society https://clinicaltrials.eu/organisation/turner-syndrome-support-society/ Wed, 29 Apr 2026 13:34:16 +0000 https://clinicaltrials.eu/organisation/turner-syndrome-support-society/ The Turner Syndrome Support Society (TSSS) actively promotes and participates in research initiatives aimed at understanding Turner Syndrome more deeply. TSSS is involved in facilitating studies that explore individual differences in cognitive ‘brain types’.

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