Traumatic pain – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:18:27 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Traumatic pain – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Comparing intranasal sufentanil and ketamine for severe acute trauma-related pain management in children admitted to pediatric emergency care https://clinicaltrials.eu/trial/comparing-intranasal-sufentanil-and-ketamine-for-severe-acute-trauma-related-pain-management-in-children-admitted-to-pediatric-emergency-care/ Thu, 30 Apr 2026 13:08:01 +0000 https://clinicaltrials.eu/trial/comparing-intranasal-sufentanil-and-ketamine-for-severe-acute-trauma-related-pain-management-in-children-admitted-to-pediatric-emergency-care/ This clinical trial focuses on treating severe acute trauma-related pain in children who have suffered limb injuries. The study compares two pain medications: sufentanil and ketamine, both given as nasal sprays. These medications are typically used in hospitals to manage severe pain, but in this study, they will be administered through the nose instead of traditional injection methods.

The main purpose is to determine which of these two medications works better for pain relief in children who come to the emergency department with severe limb injuries such as suspected fractures, severe sprains, dislocations, or joint trauma. The medications will be given as a single dose through a nasal spray, and pain levels will be monitored for up to 30 minutes after administration.

During the study, children will receive either intranasal sufentanil or intranasal ketamine. Other pain relief options like EMLA cream (a numbing cream), naloxone (a medication that reverses opioid effects), and Entonox (a mixture of nitrous oxide and oxygen for pain relief) will be available if needed. The children’s pain levels, drowsiness, and any side effects will be monitored regularly throughout the treatment period.

]]> Study on Fentanyl and Esketamine for Pain Relief in Patients with Acute Traumatic Pain https://clinicaltrials.eu/trial/study-on-fentanyl-and-esketamine-for-pain-relief-in-patients-with-acute-traumatic-pain/ Wed, 29 Apr 2026 14:23:23 +0000 https://clinicaltrials.eu/trial/study-on-fentanyl-and-esketamine-for-pain-relief-in-patients-with-acute-traumatic-pain/ This clinical trial is focused on studying treatments for acute traumatic pain, which is a sudden and severe pain resulting from an injury. The study will compare the effectiveness of different medications in managing this type of pain. The medications being tested include fentanyl and esketamine, both of which are known for their pain-relieving properties. Fentanyl will be administered either through the nose (intranasal) or directly into the bloodstream (intravenous), while esketamine will be given either through the nose or intravenously. Additionally, a placebo may be used for comparison.

The purpose of the study is to determine if intranasal fentanyl, intravenous esketamine, and intranasal esketamine are as effective as intravenous fentanyl in providing pain relief in a prehospital setting, such as in an ambulance. Participants in the study will receive one of these treatments, and their pain levels will be monitored at various intervals, including 10 and 20 minutes after receiving the medication, as well as upon arrival at the hospital. The study will also assess the need for additional doses and any side effects experienced by participants.

This trial aims to improve pain management for individuals experiencing acute traumatic pain before they reach the hospital. By comparing these treatments, the study hopes to find the most effective and safe option for pain relief in emergency situations. The trial is expected to conclude by March 2025, with recruitment having started in September 2023.

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