Transgender hormonal therapy – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 10:30:58 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Transgender hormonal therapy – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on Cardiovascular Risk Changes After Stopping and Restarting Estradiol in Older Transgender Women on Long-term Hormone Therapy https://clinicaltrials.eu/trial/study-on-cardiovascular-risk-changes-after-stopping-and-restarting-estradiol-in-older-transgender-women-on-long-term-hormone-therapy/ Wed, 29 Apr 2026 14:26:55 +0000 https://clinicaltrials.eu/trial/study-on-cardiovascular-risk-changes-after-stopping-and-restarting-estradiol-in-older-transgender-women-on-long-term-hormone-therapy/ This clinical trial is focused on studying the effects of temporarily stopping and then restarting estradiol therapy in older transgender women who have been using long-term gender-affirming hormone therapy. Estradiol is a form of estrogen, a hormone that plays a key role in the development and maintenance of female characteristics. The study will involve different forms of estradiol treatment, including transdermal patches, gels, sprays, and tablets. The purpose of the study is to explore changes in cardiovascular risk factors, such as blood pressure and cholesterol levels, after stopping and then restarting estradiol therapy.

Participants will first stop their estradiol therapy for 12 weeks, during which time various health measurements will be taken. These measurements will include height, weight, body mass index (BMI), and blood tests to check cholesterol and other health indicators. After this period, participants will restart their estradiol therapy for another 12 weeks, and the same health measurements will be repeated. The study will also look at other aspects of well-being, such as life satisfaction, happiness, and sleep quality, using questionnaires. Additionally, information about lifestyle factors like smoking and physical activity will be collected.

The study aims to provide insights into how stopping and restarting estradiol therapy affects cardiovascular health and overall well-being in older transgender women. This research could help improve understanding of the long-term effects of gender-affirming hormone therapy and guide future treatment decisions. Participants will be monitored closely throughout the study to ensure their safety and well-being.

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