Tonsillitis – European Clinical Trials Information Network

Benzydamine Hydrochloride Lozenges for Non-Streptococcal Pharyngotonsillitis in Children Aged 6 to 11 Years

Thu, 07 May 2026 05:47:13 +0000

This clinical study is being done in children with non-streptococcal pharyngotonsillitis, which is a sore throat and swollen throat and tonsils that is not caused by streptococcal bacteria. The treatment used is benzydamine hydrochloride lozenges, sold as Tantum Verde 3 mg mint-flavored lozenges. The purpose of the study is to see whether these lozenges help reduce throat pain.

In this study, the children take the lozenge and are followed for a short time after the first dose, with pain checked over the first hour and then again later over the next few days. The study looks at how the pain changes after the lozenge is placed in the mouth and how quickly the pain gets better or goes away. It also records whether any other pain medicine, such as paracetamol, or antibiotics are needed, and monitors safety during the study.

Study on Ropivacaine and Lidocaine for Reducing Pain After Tonsil Removal in Patients with Chronic Tonsillitis

Wed, 29 Apr 2026 15:06:01 +0000

This clinical trial is focused on studying the effects of two medications, Ropivacaine and Lidocaine, used as local anesthesia for patients undergoing surgery to remove their tonsils, a procedure known as a tonsillectomy. The study is particularly interested in patients who have Chronic Tonsillitis, which is a persistent inflammation of the tonsils. The main goal of the study is to determine if Ropivacaine is more effective than Lidocaine in reducing pain after the surgery.

Participants in the study will receive either Ropivacaine or Lidocaine during their tonsillectomy. The study will monitor the level of pain experienced by participants after the surgery using a tool called the Visual Analog Scale, which measures pain on a scale from 0 to 10. This will be done several times a day for the first three days after the surgery. The study will also look at how much pain medication participants need during their hospital stay and how quickly they need additional pain relief after the surgery.

The trial will last until the end of 2025, with recruitment of participants expected to start in mid-2025. The study aims to provide valuable information on which local anesthetic is more effective in managing pain after a tonsillectomy, potentially improving recovery experiences for patients with Chronic Tonsillitis.

Study on Phenoxymethylpenicillin for Patients with Severe Streptococcus Group A-Negative Acute Tonsillitis

Wed, 29 Apr 2026 14:26:20 +0000

This clinical trial is focused on studying acute tonsillitis, which is an inflammation of the tonsils often causing a sore throat and difficulty swallowing. The study is specifically looking at cases where the tonsillitis is not caused by Streptococcus group A, a common type of bacteria. The treatment being tested is an antibiotic called phenoxymethylpenicillin, which is being compared to not using any antibiotic treatment at all.

The purpose of the study is to determine if taking phenoxymethylpenicillin can reduce the duration of symptoms in patients with severe symptoms of acute tonsillitis. Participants in the study will either receive the antibiotic or no antibiotic treatment, and the researchers will observe how long it takes for their symptoms to resolve. The study will involve regular check-ins to monitor the progress of symptoms over a period of time.

This trial is designed to help understand whether using an antibiotic like phenoxymethylpenicillin is beneficial for treating severe cases of acute tonsillitis that are not caused by Streptococcus group A. The findings could provide valuable insights into the best treatment practices for this condition in primary health care settings.