Thyroidectomy – European Clinical Trials Information Network

Study of Indocyanine Green Angiography to Prevent Hypoparathyroidism in Patients Undergoing Total Thyroid Removal

Wed, 29 Apr 2026 15:01:13 +0000

This clinical trial studies the use of indocyanine green during total thyroidectomy (complete removal of the thyroid gland) to help prevent hypoparathyroidism and hypocalcemia. Hypoparathyroidism is a condition where the body doesn’t produce enough parathyroid hormone, which can lead to low blood calcium levels after thyroid surgery. Hypocalcemia occurs when calcium levels in the blood become too low, which can cause various symptoms.

The study aims to determine if using indocyanine green, a special dye that helps surgeons see blood vessels and tissues more clearly during surgery, can reduce the occurrence of low calcium levels after thyroid surgery. During the procedure, some patients will receive an injection of indocyanine green at a dose of up to 0.5 milligrams per kilogram of body weight, while others will undergo standard surgery without the dye.

The study will monitor patients’ calcium levels in their blood for up to 6 months after surgery. Doctors will check how well the parathyroid glands are working and whether patients develop any signs of low calcium levels. They will also track if using the dye helps surgeons better identify and preserve important structures during the operation.

Study on Using Indocyanine Green to Protect Parathyroid Glands During Thyroid Surgery for Patients with Hypothyroidism

Wed, 29 Apr 2026 14:57:29 +0000

This clinical trial is focused on studying the effects of a special dye called Indocyanine Green during thyroid surgery. The trial is particularly interested in patients undergoing a procedure known as a total thyroidectomy, which is the removal of the thyroid gland. This surgery may also involve the removal of lymph nodes in the neck area. The main goal of the study is to see if using Indocyanine Green can help surgeons better identify and preserve the parathyroid glands, which are small glands located near the thyroid that help control calcium levels in the body. By doing so, the study aims to reduce the risk of a condition called hypoparathyroidism, which occurs when the parathyroid glands do not produce enough hormone, leading to low calcium levels.

During the trial, some patients will receive the Indocyanine Green dye, which is injected into the bloodstream. This dye helps highlight the blood vessels and the parathyroid glands during surgery, making it easier for surgeons to see and avoid damaging them. Other patients will undergo the surgery without the use of the dye. The study will compare the outcomes of these two groups to determine if the dye is effective in preserving the parathyroid glands. The trial will also monitor various health indicators, such as calcium and hormone levels, before and after the surgery, and follow up with patients for a year to check for any signs of hypoparathyroidism.

The study is designed to provide valuable information on whether using Indocyanine Green during thyroid surgery can improve patient outcomes by reducing the risk of complications related to the parathyroid glands. This research could potentially lead to better surgical techniques and improved quality of life for patients undergoing thyroid surgery.

Study on Preventing Low Calcium Levels After Thyroid Surgery with Preoperative Cholecalciferol Supplementation for Patients Undergoing Total Thyroidectomy

Wed, 29 Apr 2026 14:23:00 +0000

This clinical trial focuses on the condition known as hypocalcemia, which can occur after a surgical procedure called thyroidectomy. A thyroidectomy is a common surgery where the thyroid gland is removed. After this surgery, some patients may experience low levels of calcium in their blood, known as hypocalcemia, which can cause discomfort and require longer hospital stays. The study is investigating whether taking a supplement called cholecalciferol, which is a form of vitamin D, before the surgery can help reduce the chances of developing hypocalcemia afterward.

The treatment being studied is an oral solution called UVEDOSE 100,000 UI, which contains cholecalciferol. Participants in the study will receive this supplement before their thyroidectomy to see if it helps their bodies respond better to the changes in calcium levels after the surgery. The study aims to assess the effect of this pre-operative supplementation on the occurrence of hypocalcemia following the surgery.

Throughout the study, participants will be monitored for signs of hypocalcemia, such as tingling in the fingers or around the mouth, and their calcium levels will be checked. The study will also look at how long participants stay in the hospital, any side effects they experience, and whether they need additional treatments for low calcium levels. The goal is to determine if pre-operative cholecalciferol supplementation can improve recovery and reduce complications after a thyroidectomy.