Syphilis – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:16:38 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Syphilis – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on the Effects of Doxycycline for Preventing Antibiotic Resistance in Patients with Bacterial STDs (Chlamydia, Gonorrhea, Syphilis) https://clinicaltrials.eu/trial/study-on-the-effects-of-doxycycline-for-preventing-antibiotic-resistance-in-patients-with-bacterial-stds-chlamydia-gonorrhea-syphilis/ Wed, 29 Apr 2026 15:05:29 +0000 https://clinicaltrials.eu/trial/study-on-the-effects-of-doxycycline-for-preventing-antibiotic-resistance-in-patients-with-bacterial-stds-chlamydia-gonorrhea-syphilis/ This clinical trial is focused on studying the effects of a medication called doxycycline on certain bacterial infections that are sexually transmitted, such as chlamydia, gonorrhea, and syphilis. The study will use a form of doxycycline known as Doxycycline EG 200 mg Tabletten, which is taken orally as a tablet. The purpose of the study is to see if taking doxycycline after being exposed to these infections can affect how bacteria in the body respond to the medication over time.

Participants in the study will take doxycycline as a preventive measure after potential exposure to these infections. The study will monitor changes in the bacteria found in the body, particularly in the intestines, to see if they become less sensitive to doxycycline. This is important because it helps understand if the bacteria are developing resistance to the medication, which could make it less effective in the future.

The study will last for several months, with participants being observed for changes in the bacteria at different points, including at the start and after 180 days. The researchers will also look at how other bacteria, such as E. coli and K. pneumoniae, respond to doxycycline and other antibiotics like ceftriaxone and ciprofloxacin. This information will help determine the impact of using doxycycline as a preventive treatment on the overall resistance of bacteria to antibiotics.

]]> Study of Linezolid and Benzathine Benzylpenicillin for Treating Patients with Early Syphilis https://clinicaltrials.eu/trial/study-of-linezolid-and-benzathine-benzylpenicillin-for-treating-patients-with-early-syphilis/ Wed, 29 Apr 2026 14:59:10 +0000 https://clinicaltrials.eu/trial/study-of-linezolid-and-benzathine-benzylpenicillin-for-treating-patients-with-early-syphilis/ This clinical trial is focused on studying the treatment of syphilis, a sexually transmitted infection caused by the bacterium Treponema pallidum. The study aims to compare the effectiveness of two antibiotics: linezolid and benzathine benzylpenicillin. Linezolid is taken orally, while benzathine benzylpenicillin is administered through an injection into the muscle. The purpose of the study is to determine if linezolid is as effective as the standard treatment with benzathine benzylpenicillin in curing early stages of syphilis.

Participants in the study will receive either linezolid or benzathine benzylpenicillin and will be monitored over a period of time to assess the healing of syphilis lesions and changes in blood tests that indicate the presence of the infection. The study will also look at the recurrence of the infection by checking for the presence of the bacterium’s DNA. The treatment period for linezolid is up to 14 days, while benzathine benzylpenicillin is given as a single dose.

Throughout the study, researchers will collect samples from participants to analyze the strains of the bacterium and to understand any potential resistance to the antibiotics. The study will also monitor any side effects experienced by participants to compare the safety of the two treatments. The goal is to provide an alternative oral treatment option for patients with early syphilis that is as effective as the current standard injection treatment.

]]> Study Comparing Doxycycline and Benzathine Benzylpenicillin for Treating Early Syphilis in Adults https://clinicaltrials.eu/trial/study-comparing-doxycycline-and-benzathine-benzylpenicillin-for-treating-early-syphilis-in-adults/ Wed, 29 Apr 2026 14:27:52 +0000 https://clinicaltrials.eu/trial/study-comparing-doxycycline-and-benzathine-benzylpenicillin-for-treating-early-syphilis-in-adults/ This clinical trial is focused on studying the treatment of early syphilis, a sexually transmitted infection that can cause serious health problems if not treated. The study compares two treatments: doxycycline and benzathine benzylpenicillin (BPG). Doxycycline is an antibiotic taken orally in the form of a tablet, while benzathine benzylpenicillin is given as a single injection into the muscle.

The purpose of the study is to determine if taking doxycycline twice a day for 14 days is as effective as a single injection of benzathine benzylpenicillin for treating early syphilis. Participants in the study will be randomly assigned to receive either the doxycycline tablets or the benzathine benzylpenicillin injection. The effectiveness of the treatments will be evaluated by checking for a decrease in the level of the infection in the blood after six months.

Throughout the study, participants will have regular follow-up visits to monitor their health and the progress of the treatment. The study aims to provide valuable information on the effectiveness of these treatments for early syphilis, which could help improve future treatment options for this condition.

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