Streptococcal infection – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Mon, 22 Jun 2026 04:02:07 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Streptococcal infection – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Short Course Amoxicillin for Children with Acute Streptococcal Pharyngotonsillitis: A Phase III Randomized Trial https://clinicaltrials.eu/trial/shorter-5-day-amoxicillin-treatment-versus-7-day-course-in-children-aged-2-17-with-acute-streptococcal-pharyngotonsillitis-a-phase-iii-non-inferiority-trial/ Wed, 17 Jun 2026 04:03:07 +0000 https://clinicaltrials.eu/trial/shorter-5-day-amoxicillin-treatment-versus-7-day-course-in-children-aged-2-17-with-acute-streptococcal-pharyngotonsillitis-a-phase-iii-non-inferiority-trial/ The condition being studied is acute streptococcal pharyngotonsillitis, a common throat infection caused by a type of bacteria that leads to sore throat, fever, and swollen tonsils. The medication tested in the study is the oral antibiotic amoxicillin, which is used to kill the bacteria that cause the infection.

The purpose of the trial is to determine whether a shorter 5‑day course of the antibiotic is not worse than the standard 7‑day course in preventing a repeat infection, called a relapse, within about two weeks after treatment ends. Children between 2 and 17 years old will be assigned by chance to receive either the 5‑day or the 7‑day regimen, take the medicine at home, and then be followed for several weeks to see if fever goes away, if symptoms return, or if any complications develop. A relapse means the infection comes back after the prescribed antibiotics have been finished.

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