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	<title>Squamous cell carcinoma of the oral cavity &#8211; European Clinical Trials Information Network</title>
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	<title>Squamous cell carcinoma of the oral cavity &#8211; European Clinical Trials Information Network</title>
	<link>https://clinicaltrials.eu</link>
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		<title>Study of carboplatin, paclitaxel, and tislelizumab treatment in patients with resectable locally advanced oral cavity squamous cell carcinoma</title>
		<link>https://clinicaltrials.eu/trial/study-of-carboplatin-paclitaxel-and-tislelizumab-treatment-in-patients-with-resectable-locally-advanced-oral-cavity-squamous-cell-carcinoma/</link>
		
		<dc:creator><![CDATA[]]></dc:creator>
		<pubDate>Wed, 29 Apr 2026 15:06:30 +0000</pubDate>
				<guid isPermaLink="false">https://clinicaltrials.eu/trial/study-of-carboplatin-paclitaxel-and-tislelizumab-treatment-in-patients-with-resectable-locally-advanced-oral-cavity-squamous-cell-carcinoma/</guid>

					<description><![CDATA[This study focuses on patients with Oral Cavity Squamous Cell Carcinoma, a type of cancer that develops in the mouth tissues. The study will test a combination of three medications: tislelizumab, carboplatin, and paclitaxel. These medications will be given through intravenous infusion (delivered directly into a vein). The purpose is to evaluate how well this [&#8230;]]]></description>
										<content:encoded><![CDATA[<p>This study focuses on patients with <b>Oral Cavity Squamous Cell Carcinoma</b>, a type of cancer that develops in the mouth tissues. The study will test a combination of three medications: <b>tislelizumab</b>, <b>carboplatin</b>, and <b>paclitaxel</b>. These medications will be given through <b>intravenous</b> infusion (delivered directly into a vein). The purpose is to evaluate how well this combination of drugs works in treating locally advanced oral cavity cancer that can be removed by surgery.</p>
<p>The treatment involves receiving the three medications before surgery. <b>Tislelizumab</b> is a newer type of drug that helps the immune system fight cancer cells, while <b>carboplatin</b> and <b>paclitaxel</b> are established chemotherapy medications that work by stopping cancer cells from growing and dividing. The medications will be given in cycles through an intravenous line, with specific doses calculated based on each patient&#8217;s body measurements.</p>
<p>The study will measure how well the treatment works by examining the cancer tissue removed during surgery and checking how many cancer cells remain after the treatment. Doctors will also monitor patients&#8217; health during and after treatment to understand how safe this combination of medications is and how well it prevents the cancer from returning.</p>
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		<title>Study on Pembrolizumab and Drug Combination for Patients with Recurrent Head and Neck Cancer</title>
		<link>https://clinicaltrials.eu/trial/study-on-pembrolizumab-and-drug-combination-for-patients-with-recurrent-head-and-neck-cancer/</link>
		
		<dc:creator><![CDATA[]]></dc:creator>
		<pubDate>Wed, 29 Apr 2026 15:05:01 +0000</pubDate>
				<guid isPermaLink="false">https://clinicaltrials.eu/trial/study-on-pembrolizumab-and-drug-combination-for-patients-with-recurrent-head-and-neck-cancer/</guid>

					<description><![CDATA[This clinical trial is focused on studying a type of cancer called locoregionally recurrent head and neck squamous cell carcinoma (HNSCC). This is a condition where cancer returns in the head and neck area after initial treatment. The study will explore the effectiveness of a treatment plan that includes a combination of therapies. The main [&#8230;]]]></description>
										<content:encoded><![CDATA[<p>This clinical trial is focused on studying a type of cancer called <i>locoregionally recurrent head and neck squamous cell carcinoma (HNSCC)</i>. This is a condition where cancer returns in the head and neck area after initial treatment. The study will explore the effectiveness of a treatment plan that includes a combination of therapies. The main treatment being tested is <i>pembrolizumab</i>, which is a type of immunotherapy that helps the immune system fight cancer. The study will compare this treatment to the standard therapy, which may include pembrolizumab with or without chemotherapy.</p>
<p>The trial will involve several medications, including <i>fluorouracil</i>, <i>carboplatin</i>, and <i>cisplatin</i>, which are types of chemotherapy drugs. These medications are given to help stop the growth of cancer cells. The purpose of the study is to see if the new treatment plan can improve the overall survival of patients with this type of cancer. Participants in the study will receive these treatments over a period of time, and their health will be monitored to see how well the treatment works.</p>
<p>The study will follow a specific course where participants will receive the treatments through <i>intravenous infusion</i>, which means the medication is given directly into a vein. The trial aims to find out if the new treatment plan can help patients live longer and control the cancer better than the current standard treatments. The study will also look at other factors, such as how the treatment affects the quality of life and any side effects that may occur. The ultimate goal is to find a more effective way to treat this type of cancer and improve the lives of those affected by it.</p>
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		<title>Study on Detecting Sentinel Lymph Nodes in Early Oral Cancer Using Gallium-68-Tilmanocept and Technetium-99m in Patients with Oral Cancer</title>
		<link>https://clinicaltrials.eu/trial/study-on-detecting-sentinel-lymph-nodes-in-early-oral-cancer-using-gallium-68-tilmanocept-and-technetium-99m-in-patients-with-oral-cancer/</link>
		
		<dc:creator><![CDATA[]]></dc:creator>
		<pubDate>Wed, 29 Apr 2026 15:04:39 +0000</pubDate>
				<guid isPermaLink="false">https://clinicaltrials.eu/trial/study-on-detecting-sentinel-lymph-nodes-in-early-oral-cancer-using-gallium-68-tilmanocept-and-technetium-99m-in-patients-with-oral-cancer/</guid>

					<description><![CDATA[This clinical trial is focused on detecting sentinel lymph nodes in patients with early-stage oral cancer, specifically oral squamous cell carcinoma. The study will use a special imaging technique called PET/CT with a substance known as Gallium-68-Tilmanocept. This substance helps doctors see the lymph nodes more clearly. The trial will also use another substance called [&#8230;]]]></description>
										<content:encoded><![CDATA[<p>This clinical trial is focused on detecting sentinel lymph nodes in patients with early-stage <i>oral cancer</i>, specifically oral squamous cell carcinoma. The study will use a special imaging technique called <i>PET/CT</i> with a substance known as <i>Gallium-68-Tilmanocept</i>. This substance helps doctors see the lymph nodes more clearly. The trial will also use another substance called <i>Technetium (99mTc)</i> for comparison. Both substances are used to help identify the lymph nodes that may be affected by cancer.</p>
<p>The purpose of the study is to determine how accurately the <i>Gallium-68-Tilmanocept PET/CT</i> can detect these lymph nodes compared to the traditional method using <i>Technetium (99mTc)</i>. Participants in the study will undergo imaging with both methods before their surgery. This will help doctors understand which method is better at finding the lymph nodes that need to be examined for cancer spread.</p>
<p>During the study, participants will receive a small amount of the imaging substances near the tumor area. This is done to highlight the lymph nodes during the imaging process. The study aims to improve the way doctors detect and treat <i>oral cancer</i> by finding the most effective method for identifying affected lymph nodes. The trial will help gather important information that could lead to better outcomes for patients with this type of cancer.</p>
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		<title>Study of low-dose radiation therapy combined with paclitaxel and carboplatin in patients with advanced throat and larynx cancer</title>
		<link>https://clinicaltrials.eu/trial/study-on-the-effectiveness-of-low-dose-radiochemotherapy-with-carboplatin-and-paclitaxel-for-patients-with-advanced-throat-and-larynx-cancer/</link>
		
		<dc:creator><![CDATA[]]></dc:creator>
		<pubDate>Wed, 29 Apr 2026 15:02:24 +0000</pubDate>
				<guid isPermaLink="false">https://clinicaltrials.eu/trial/study-on-the-effectiveness-of-low-dose-radiochemotherapy-with-carboplatin-and-paclitaxel-for-patients-with-advanced-throat-and-larynx-cancer/</guid>

					<description><![CDATA[This clinical trial focuses on patients with advanced throat and larynx cancer. The study evaluates a treatment approach called induction radiochemotherapy that uses low doses of ionizing radiation combined with chemotherapy medications. The chemotherapy drugs used in this study are paclitaxel and carboplatin, which are given through an intravenous injection directly into the bloodstream. The [&#8230;]]]></description>
										<content:encoded><![CDATA[<p>This clinical trial focuses on patients with <b>advanced throat and larynx cancer</b>. The study evaluates a treatment approach called induction radiochemotherapy that uses low doses of <b>ionizing radiation</b> combined with chemotherapy medications. The chemotherapy drugs used in this study are <b>paclitaxel</b> and <b>carboplatin</b>, which are given through an <b>intravenous</b> injection directly into the bloodstream.</p>
<p>The purpose of this research is to determine how effective and well-tolerated this combined treatment approach is for patients with advanced throat and larynx cancer. The treatment involves receiving both chemotherapy medications along with low-dose radiation therapy. During the study, patients will receive treatment over a period of up to 37 days.</p>
<p>The study will monitor how patients respond to the treatment by examining the cancer&#8217;s response, checking for any spread of the disease, and tracking overall patient survival. The research will also look at how low doses of radiation affect the body at both molecular and biochemical levels. Throughout the treatment period, doctors will carefully watch for and record any side effects that patients may experience.</p>
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		<title>Study on the Safety and Effectiveness of Afatinib for Fanconi Anemia Patients with Advanced Squamous Cell Carcinoma in the Oral Cavity, Oropharynx, Hypopharynx, or Larynx</title>
		<link>https://clinicaltrials.eu/trial/study-on-the-safety-and-effectiveness-of-afatinib-for-fanconi-anemia-patients-with-advanced-squamous-cell-carcinoma-in-the-oral-cavity-oropharynx-hypopharynx-or-larynx/</link>
		
		<dc:creator><![CDATA[]]></dc:creator>
		<pubDate>Wed, 29 Apr 2026 15:01:07 +0000</pubDate>
				<guid isPermaLink="false">https://clinicaltrials.eu/trial/study-on-the-safety-and-effectiveness-of-afatinib-for-fanconi-anemia-patients-with-advanced-squamous-cell-carcinoma-in-the-oral-cavity-oropharynx-hypopharynx-or-larynx/</guid>

					<description><![CDATA[This clinical trial is focused on studying the effects of a medication called Afatinib in patients with a rare genetic disorder known as Fanconi anemia. This disorder can lead to a type of cancer called squamous cell carcinoma, which affects areas such as the mouth, throat, and voice box. The study aims to understand how [&#8230;]]]></description>
										<content:encoded><![CDATA[<p>This clinical trial is focused on studying the effects of a medication called <i>Afatinib</i> in patients with a rare genetic disorder known as <i>Fanconi anemia</i>. This disorder can lead to a type of cancer called <i>squamous cell carcinoma</i>, which affects areas such as the mouth, throat, and voice box. The study aims to understand how safe and effective <i>Afatinib</i> is when used to treat these cancers, especially when they cannot be surgically removed or have spread to other parts of the body.</p>
<p>The treatment involves taking <i>Afatinib</i> in the form of film-coated tablets, which are taken orally. The study will compare the effects of different doses of <i>Afatinib</i> to see how well it works in controlling the cancer and improving the quality of life for patients. Participants will be monitored for any side effects and how their cancer responds to the treatment over a period of time.</p>
<p>The purpose of this study is to gather information on the effectiveness of <i>Afatinib</i> in treating cancers associated with <i>Fanconi anemia</i>. The study will also look at how long the treatment effects last, the overall survival of patients, and any changes in their health-related quality of life. This information will help in understanding the potential benefits and risks of using <i>Afatinib</i> for this specific group of patients.</p>
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		<title>Study of Pembrolizumab with Lenvatinib after Chemoradiation Treatment in Patients with Locally Advanced Head and Neck Cancer who are PD-L1 Positive</title>
		<link>https://clinicaltrials.eu/trial/study-of-pembrolizumab-and-lenvatinib-for-patients-with-advanced-head-and-neck-cancer-after-chemoradiation/</link>
		
		<dc:creator><![CDATA[]]></dc:creator>
		<pubDate>Wed, 29 Apr 2026 14:59:19 +0000</pubDate>
				<guid isPermaLink="false">https://clinicaltrials.eu/trial/study-of-pembrolizumab-and-lenvatinib-for-patients-with-advanced-head-and-neck-cancer-after-chemoradiation/</guid>

					<description><![CDATA[This study focuses on patients with locally advanced head and neck squamous cell carcinoma, a type of cancer that develops in the cells lining the mouth, throat, or surrounding areas. The research examines two medications: pembrolizumab and lenvatinib. These medications will be given to patients after they have completed their initial cancer treatment with chemotherapy [&#8230;]]]></description>
										<content:encoded><![CDATA[<p>This study focuses on patients with <b>locally advanced head and neck squamous cell carcinoma</b>, a type of cancer that develops in the cells lining the mouth, throat, or surrounding areas. The research examines two medications: <b>pembrolizumab</b> and <b>lenvatinib</b>. These medications will be given to patients after they have completed their initial cancer treatment with chemotherapy and radiation therapy.</p>
<p>The purpose of this research is to determine if using both pembrolizumab and lenvatinib together works better than using pembrolizumab alone in preventing cancer from returning. Pembrolizumab is given through an <b>intravenous</b> infusion into a vein, while lenvatinib is taken as oral capsules. The treatment period may last up to 47 weeks.</p>
<p>The study will include patients whose cancer cells have a specific characteristic called <b>PD-L1</b>, which is a protein found on some cancer cells. Patients will receive regular medical check-ups throughout the study period to monitor their health and evaluate how well the treatment is working. The medications being studied are designed to help the body&#8217;s immune system fight cancer cells.</p>
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