Skin wrinkling – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 19 Jun 2026 04:03:07 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Skin wrinkling – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Corabotase for Moderate to Severe Glabellar Lines in Adults https://clinicaltrials.eu/trial/efficacy-and-safety-of-corabotase-for-moderate-to-severe-glabellar-lines-in-adult-patients/ Wed, 13 May 2026 05:05:02 +0000 https://clinicaltrials.eu/trial/efficacy-and-safety-of-corabotase-for-moderate-to-severe-glabellar-lines-in-adult-patients/ This clinical trial is being done to see how well IPN10200 works and how safe it is for adults with moderate to severe glabellar lines, which are the wrinkle-like lines between the eyebrows. The study treatment is CORABOTASE, given as a single intramuscular injection, meaning it is injected into a muscle. Some participants will receive a placebo during the first part of the study. The study also compares repeated doses over time to learn more about the longer-term effects of the treatment.

The study has two main parts. In the first part, participants receive one injection and are followed for several weeks to see how the lines change and how safe the treatment is. In the second part, some participants may receive more injections over time in an open-label phase, which means the treatment given is known. During the study, the face and general health are checked, and possible side effects are watched closely. Blood tests may also be done to look for antibodies, which are proteins the body can make against a medicine.

The study focuses on whether the lines between the eyebrows become less noticeable after treatment and whether the treatment remains safe with repeated use. It also looks at how long the effect lasts and how often repeat treatment may be needed.

]]> Study on the Safety and Effectiveness of IPN10200 and Botulinum Toxin Type A for Adults with Moderate to Severe Upper Facial Lines https://clinicaltrials.eu/trial/study-on-the-safety-and-effectiveness-of-ipn10200-and-botulinum-toxin-type-a-for-adults-with-moderate-to-severe-upper-facial-lines/ Mon, 04 May 2026 07:52:25 +0000 https://clinicaltrials.eu/trial/study-on-the-safety-and-effectiveness-of-ipn10200-and-botulinum-toxin-type-a-for-adults-with-moderate-to-severe-upper-facial-lines/ This clinical trial is focused on studying the treatment of moderate to severe upper facial lines, which are common concerns for many adults. The study will evaluate a new treatment called IPN10200, which is a type of botulinum toxin used to improve the appearance of these facial lines. Participants in the study will receive either the IPN10200 treatment or a placebo, which is a substance with no active medication, to compare the effects.

The purpose of the study is to assess the safety and effectiveness of IPN10200 in reducing the appearance of facial lines. The study will involve a series of visits where participants will receive injections and have their facial lines assessed by both doctors and themselves. The study will last for several weeks, with the main assessment taking place on Day 29 after the treatment. Participants will be monitored for any side effects and changes in their facial lines throughout the study.

During the study, participants will be asked to attend regular check-ups to monitor their health and the effects of the treatment. These check-ups will include physical examinations and assessments of facial lines. The study aims to find the best dose of IPN10200 that is both safe and effective in improving the appearance of facial lines. The results will help determine if IPN10200 can be a useful treatment option for people with moderate to severe upper facial lines.

]]> Study on the Effectiveness of Clostridium Botulinum Neurotoxin Type A for Reducing Wrinkles in Adults https://clinicaltrials.eu/trial/study-on-the-effectiveness-of-clostridium-botulinum-neurotoxin-type-a-for-reducing-wrinkles-in-adults/ Wed, 29 Apr 2026 15:05:46 +0000 https://clinicaltrials.eu/trial/study-on-the-effectiveness-of-clostridium-botulinum-neurotoxin-type-a-for-reducing-wrinkles-in-adults/ This clinical trial is focused on studying the effects of a treatment for wrinkles and fine lines on the face. The treatment being tested is called Bocouture, which contains a substance known as Clostridium botulinum neurotoxin type A. This substance is commonly used in cosmetic procedures to reduce the appearance of wrinkles by temporarily relaxing the muscles.

The purpose of the study is to evaluate how satisfied participants are with the results of the treatment. Participants will receive either the actual treatment or a placebo, which is a substance with no active ingredients. The study will compare the satisfaction levels of those who receive the treatment with those who receive the placebo. The treatment will be administered in split doses, meaning it will be given in smaller amounts but more frequently than usual.

Participants will be involved in the study for a period of time, during which they will receive the treatment and attend follow-up visits. The main focus will be on the change in satisfaction from the beginning of the study to two months after the last treatment. The study will also monitor any adverse events, which are any unexpected or negative reactions to the treatment. The goal is to understand the overall satisfaction with the treatment and its safety.

]]> Study Comparing the Effectiveness and Safety of Botulinum Toxin Type A Products for Treating Frown Lines in Adults https://clinicaltrials.eu/trial/study-comparing-the-effectiveness-and-safety-of-botulinum-toxin-type-a-products-for-treating-frown-lines-in-adults/ Wed, 29 Apr 2026 15:05:24 +0000 https://clinicaltrials.eu/trial/study-comparing-the-effectiveness-and-safety-of-botulinum-toxin-type-a-products-for-treating-frown-lines-in-adults/ This clinical trial is focused on studying the effectiveness and safety of different treatments for glabellar frown lines, which are the wrinkles that appear between the eyebrows. The study will compare five different products that contain botulinum toxin type A, a substance commonly used to reduce wrinkles. The products being tested are NUCEIVA, Azzalure, VISTABEL, BOCOUTURE, and another product with a similar active ingredient. These treatments are administered as injections.

The purpose of the study is to determine which of these products is most effective in reducing the appearance of glabellar frown lines over time. Participants will receive one of the treatments or a placebo and will be monitored to see how long the effects last. The study will also track any side effects and how the treatments impact participants’ quality of life, including their psychological wellbeing and social interactions.

Throughout the study, participants will be asked to report on their satisfaction with the treatment and any changes in their anxiety or depression levels. The study will also assess the impact of the treatments on headaches and migraines. The trial is designed to provide clear evidence to help doctors make informed decisions about the best treatment options for reducing glabellar frown lines.

]]> Study on the Safety and Effectiveness of Dantrolene Sodium and Botulinum Toxin Type A for Treating Severe Glabellar Lines in Adults https://clinicaltrials.eu/trial/study-on-the-safety-and-effectiveness-of-dantrolene-sodium-and-botulinum-toxin-type-a-for-treating-severe-glabellar-lines-in-adults/ Wed, 29 Apr 2026 15:05:18 +0000 https://clinicaltrials.eu/trial/study-on-the-safety-and-effectiveness-of-dantrolene-sodium-and-botulinum-toxin-type-a-for-treating-severe-glabellar-lines-in-adults/ This clinical trial is focused on studying the treatment of glabellar lines, which are the vertical lines that appear between the eyebrows when frowning. The study will use a combination of two substances: dantrolene sodium and botulinum toxin type A, known together as the FTP-002/FTP-501 combination. These substances are used to help relax muscles and reduce the appearance of these lines. The trial will also involve the use of sodium chloride as a comparison treatment, often referred to as a placebo.

The purpose of the study is to evaluate the safety and effectiveness of the FTP-002/FTP-501 combination in treating severe glabellar lines. Participants will receive a single injection of the treatment, and the study will compare the results of those receiving the combination treatment to those receiving only FTP-002 or a placebo. The study will monitor how well the treatment works and how long the effects last.

Participants will be observed over a period of time to assess any improvements in the appearance of their glabellar lines. The study aims to determine if the treatment can provide a noticeable reduction in the severity of these lines and how long the improvement lasts. The trial will help to understand the potential benefits and any side effects of using the FTP-002/FTP-501 combination for this cosmetic concern.

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