Skin wound – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Tue, 02 Jun 2026 09:56:37 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Skin wound – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Verteporfin for Scar Prevention in Patients After Surgical Wounds https://clinicaltrials.eu/trial/verteporfin-for-scar-prevention-after-surgery-in-patients-with-surgical-wounds/ Tue, 02 Jun 2026 09:56:37 +0000 https://clinicaltrials.eu/trial/verteporfin-for-scar-prevention-after-surgery-in-patients-with-surgical-wounds/ This study is being done in surgical wounds to see whether verteporfin can help prevent scar formation after surgery. The treatment will be given as an injection into the skin, and different doses of verteporfin will be compared with saline, which is also given by injection. The purpose of the study is to find the best dose and to see whether verteporfin may improve scar prevention.

People in the study will have either closed wounds, such as stitched cuts, or open wounds, such as small biopsy wounds made during the study. After treatment, the wounds will be followed over time while they heal, and the scars will be checked later. The study will also look at how safe the treatment is and whether any side effects occur, such as skin reactions or other body reactions. Some scars will also be looked at with medical pictures and ultrasound, which is a test that uses sound waves to create images inside the body.

Scar prevention is the main focus of this trial, and the study is designed to compare three verteporfin doses with saline in both open and closed wound types. The study will continue until the healing and scar checks are completed after treatment.

]]> Safety, tolerability and efficacy of topical human fibroblasts in patients with chronic refractory wounds (two-part study) https://clinicaltrials.eu/trial/safety-tolerability-and-efficacy-of-topical-human-fibroblasts-in-patients-with-chronic-refractory-wounds-two-part-study/ Wed, 27 May 2026 04:05:20 +0000 https://clinicaltrials.eu/trial/safety-tolerability-and-efficacy-of-topical-human-fibroblasts-in-patients-with-chronic-refractory-wounds-two-part-study/ The trial focuses on refractory wounds, which are skin sores that have not healed despite usual medical care. The treatment being tested is a skin‑applied patch called FB-Plus that contains human fibroblasts. Fibroblasts are normal cells that help build and repair the tissue that makes up skin, and in this product they come from a donor (this is called allogeneic fibroblasts).

The purpose of the study is to see whether a single application of the patch is safe and well tolerated and, in the second part, whether it can help wounds get smaller or heal completely. The first phase will compare two different strengths of the patch, looking for any side effects. The dose that appears safest and most promising will be used in the later phase to test how well the wound improves.

Participants will receive one patch during each phase and will be followed for a period of time to check for any reactions, changes in vital signs, and overall comfort. In the expansion phase, researchers will also measure the size of the wound, pain levels, and how satisfied they are with the result, using simple scales and questionnaires that are easy to understand.

]]> Testing Bacteriophage Cocktail Safety and Effectiveness in Patients with Complicated Infected Wounds Compared to Placebo https://clinicaltrials.eu/trial/testing-bacteriophage-cocktail-safety-and-effectiveness-in-patients-with-complicated-infected-wounds-compared-to-placebo/ Thu, 30 Apr 2026 13:08:46 +0000 https://clinicaltrials.eu/trial/testing-bacteriophage-cocktail-safety-and-effectiveness-in-patients-with-complicated-infected-wounds-compared-to-placebo/ This study examines the treatment of complicated skin wounds that are infected with certain bacteria. The wounds being studied include infected surgical wounds, traumatic wounds, or chronic wounds that are healing slowly and are infected with either Staphylococcus aureus or Pseudomonas aeruginosa bacteria, or both. The study will test a treatment called DUOFAG, which is a bacteriophage cocktail applied directly to the wound. Bacteriophages are viruses that specifically target and destroy bacteria. The treatment will be compared to a placebo, which is sodium chloride solution.

The purpose of this study is to show whether DUOFAG is safe and can reduce or completely eliminate Staphylococcus aureus and Pseudomonas aeruginosa bacteria from infected wounds over a period of 14 days. The study will also look at how often any unwanted reactions occur during treatment and whether the treatment helps wounds heal better.

During the study, the treatment will be applied directly to the wound for up to 14 days. Samples from the wound will be taken regularly to check whether the bacteria are still present and to count how many bacteria remain. The study will monitor participants for any side effects during the treatment period and for some time afterward. The study will also measure changes in the wound condition and track how long it takes for the infection to clear and for the wound to heal completely if this happens during the study period.

]]> Study of the effect of hyperbaric oxygen therapy on the bacteria in chronic wounds https://clinicaltrials.eu/trial/study-of-the-effect-of-hyperbaric-oxygen-therapy-on-the-bacteria-in-chronic-wounds/ Wed, 29 Apr 2026 15:09:12 +0000 https://clinicaltrials.eu/trial/study-of-the-effect-of-hyperbaric-oxygen-therapy-on-the-bacteria-in-chronic-wounds/ This study focuses on individuals living with chronic wounds, which are sores that do not heal within the expected timeframe. The research aims to evaluate the impact of hyperbaric oxygen therapy, a method where a person breathes oxygen through a specialized breathing tube while inside a pressurized chamber, on the types of bacteria living in these wounds. These bacteria are part of the wound microbiome, which refers to the collection of tiny living organisms that inhabit the area around and inside the wound.

Participants will undergo a period of treatment lasting six weeks. During this time, the effects of the pressurized oxygen on the wound’s environment and the healing process will be observed. The study will look at how the different types of microorganisms in the wound change and how this influences the body’s ability to repair the tissue and reduce the size of the sore.

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