Sedation – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Tue, 02 Jun 2026 04:13:39 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Sedation – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on Sevoflurane and Propofol for Heart Protection in Double Valve Surgery Patients https://clinicaltrials.eu/trial/study-on-sevoflurane-and-propofol-for-heart-protection-in-double-valve-surgery-patients/ Wed, 29 Apr 2026 15:02:45 +0000 https://clinicaltrials.eu/trial/study-on-sevoflurane-and-propofol-for-heart-protection-in-double-valve-surgery-patients/ This clinical trial is focused on patients undergoing double valve surgery, a procedure involving the replacement or repair of two heart valves. The study aims to compare the effects of two medications, Sevoflurane and Propofol, during and after the surgery. Sevoflurane is commonly used as an anesthetic gas, while Propofol is an injectable anesthetic. The purpose of the study is to evaluate how these medications affect heart and kidney protection during the surgery, particularly in reducing heart muscle damage and injury.

During the trial, patients will receive either Sevoflurane or Propofol while undergoing surgery. The study will monitor various health indicators, such as heart function and kidney health, by measuring specific proteins and enzymes in the blood. These include NT-ProBNP and Troponin I, which are markers of heart stress and damage. The trial will also assess the need for medications that support heart function if the heart’s output is low after surgery.

The study will take place over a period of time, with patients being observed both during the surgery and in the recovery phase. The goal is to determine which medication provides better protection for the heart and kidneys, potentially leading to improved outcomes for patients undergoing this type of heart surgery. The trial is expected to conclude by May 2025.

]]> A Study Comparing Remimazolam and Midazolam for Sedation in Adults During Upper Gastrointestinal Endoscopy https://clinicaltrials.eu/trial/sedation-study-for-upper-gi-endoscopy-comparing-remimazolam-and-midazolam-in-adult-patients/ Wed, 29 Apr 2026 14:59:49 +0000 https://clinicaltrials.eu/trial/sedation-study-for-upper-gi-endoscopy-comparing-remimazolam-and-midazolam-in-adult-patients/ This study compares two medications used for sedation during upper gastrointestinal endoscopy (a procedure to examine the upper digestive tract). The medications being studied are remimazolam (Byfavo) and midazolam, which are both sedative drugs given through an intravenous injection to help patients relax during the procedure.

The purpose of this research is to evaluate how long it takes patients to fully recover after receiving these sedative medications during their endoscopy procedure. During the study, participants will receive either remimazolam or midazolam as their sedation medication. After the procedure, medical staff will monitor how quickly patients return to being fully alert and ready to go home.

The medications will be given through a vein as either a single injection or continuous infusion. The maximum amount of medication that can be given is 100 mg for either drug over the course of one day. Throughout the procedure and recovery period, patients will be closely monitored for their response to the medication and any possible side effects.

]]> Study on the Effectiveness of Spinal Anesthesia vs. Sedation for Turning Breech Babies: Comparing Midazolam and Bupivacaine in Pregnant Women https://clinicaltrials.eu/trial/study-on-the-effectiveness-of-spinal-anesthesia-vs-sedation-for-turning-breech-babies-comparing-midazolam-and-bupivacaine-in-pregnant-women/ Wed, 29 Apr 2026 14:58:54 +0000 https://clinicaltrials.eu/trial/study-on-the-effectiveness-of-spinal-anesthesia-vs-sedation-for-turning-breech-babies-comparing-midazolam-and-bupivacaine-in-pregnant-women/ This clinical trial is focused on the effectiveness of different types of anaesthesia during a procedure called external version, which is used to change the position of a baby in the womb from a breech or sideways position to a head-down position. The study compares two methods: spinal anaesthesia and sedation. The main goal is to determine if spinal anaesthesia leads to a higher success rate in repositioning the baby compared to sedation.

The study involves the use of two medications: Midazolam, also known by its code name USL-261, which is used for sedation, and Bupivacaine, which is used for spinal anaesthesia. Midazolam is administered as a solution for injection or infusion, while Bupivacaine is given as an injectable solution. Participants in the study will receive either spinal anaesthesia or sedation during the procedure, and the outcomes will be compared to see which method is more effective.

Throughout the study, participants will be monitored for the success of the procedure, which is defined as the baby being in a head-down position after the procedure. Additionally, any side effects related to the procedure or the anaesthesia, such as changes in blood pressure or heart rate, will be recorded. The study aims to provide valuable information on the best anaesthesia method to use for this procedure, potentially improving outcomes for both mothers and babies.

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