Radius fracture – European Clinical Trials Information Network

Study on Post-Surgery Pain Relief for Radius Fracture Patients Using Ropivacaine and Oxycodone

Wed, 29 Apr 2026 15:04:07 +0000

This clinical trial is focused on studying the effects of different concentrations of a medication called ropivacaine on pain experienced after surgery for a type of wrist fracture known as a radius fracture. The surgery involves using a volar plate, which is a method to stabilize the broken bone. The trial aims to understand if the concentration of ropivacaine, used in a nerve block, affects the severity of pain after the operation.

Participants in the study will receive either a lower concentration (3.75 mg/ml) or a higher concentration (7.5 mg/ml) of ropivacaine. This medication is administered as an injection to numb the area around the shoulder, known as the infraclavicular brachial plexus block, to help manage pain during and after the surgery. The study will compare the pain levels experienced by participants receiving the different concentrations of ropivacaine.

Throughout the study, participants’ pain levels will be monitored at various intervals, including immediately after surgery and up to six weeks later. The study will also track the use of additional pain relief medications, such as OxyContin, OxyNorm, ARCOXIA, Paracet, and Dexamethasone, to understand their impact on managing pain. The goal is to determine the most effective concentration of ropivacaine for reducing pain after this type of surgery.

Study on Brachial Plexus Nerve Block with Epinephrine and Lidocaine for Adults with Distal Radius Fracture Needing Closed Reduction

Wed, 29 Apr 2026 14:59:36 +0000

This clinical trial is focused on studying the treatment of distal radius fractures, which are breaks near the wrist end of the forearm bone. The trial will compare two methods for managing these fractures: a brachial plexus nerve block and standard care. A brachial plexus nerve block is a procedure where a numbing medication is injected near the nerves of the shoulder to block pain in the arm. The medication used in this procedure is a combination of epinephrine and lidocaine hydrochloride, which is administered as a solution for injection.

The purpose of the study is to evaluate the effects of using an ultrasound-guided brachial plexus nerve block for patients who need a closed reduction, which is a non-surgical method to realign the broken bone. Participants in the study will receive either the nerve block or standard care, and their progress will be monitored over a period of time. The study will look at various outcomes, such as the need for surgery within 90 days, any complications related to the treatment, and the level of pain experienced during the procedure.

Throughout the study, researchers will also assess the position of the fracture after the procedure and any new injuries or complications that may arise. The trial aims to provide valuable information on the benefits and risks of using a brachial plexus nerve block compared to standard care for treating distal radius fractures.

Comparison of Lidocaine and Ropivacaine in Ultrasound-Guided Nerve Block for Patients with Wrist Fractures Requiring Closed Reduction

Wed, 29 Apr 2026 14:30:30 +0000

This study focuses on treating patients with distal radius fractures (broken wrist bones) that require closed reduction (a procedure to realign the broken bones without surgery). The study compares two different local anesthetic medications: Ropivacaine and Lidocaine with epinephrine, which are drugs used to block pain and relax muscles in the affected area.

The purpose of this research is to evaluate how well these medications work when given through a nerve block called lateral infraclavicular brachial plexus block. This is an injection technique where medication is delivered near the nerves in the shoulder area using ultrasound guidance to help control pain during the bone realignment procedure.

During the study, participants will receive one of these pain-blocking medications through an injection. The medications will be given in different strengths but in the same amount of liquid. The effectiveness of the nerve block will be checked 45 minutes after the injection is given, before proceeding with the bone realignment and casting procedure.

Study on Long-term Safety of NVDX3 Implant for Patients with Distal Radius Fracture or Low-grade Degenerative Lumbar Spondylolisthesis

Wed, 29 Apr 2026 14:27:29 +0000

This clinical trial is focused on studying the long-term safety of a treatment called NVDX3, which is an implant used in certain bone-related conditions. The diseases being studied in this trial include Distal Radius fracture, a type of wrist fracture, and Low grade degenerative lumbar spondylolisthesis, a condition affecting the spine where one of the vertebrae slips out of place. The treatment, NVDX3, is an osteogenic implant, meaning it is designed to support bone growth and repair, and it is made from human allogenic origin, which refers to cells or tissues obtained from a donor of the same species.

The purpose of this study is to document the long-term safety of the NVDX3 implant. Participants in the study will have previously been involved in core clinical trials with NVDX3 and will continue to be monitored for safety over a period of 10 additional years. This involves yearly follow-up visits to ensure the implant remains safe for use over a long period. The study will collect information on any serious adverse events (SAEs) or other side effects related to the implant from the time of screening until 10 years after the initial study.

Participants in this study will have agreed to these follow-up visits and will have signed an informed consent form to confirm their understanding and willingness to participate in this long-term safety study. The study aims to provide valuable information on the safety of the NVDX3 implant for patients with the specified conditions, contributing to the understanding of its long-term effects and potential benefits.