Prophylaxis – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Tue, 02 Jun 2026 12:26:08 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Prophylaxis – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on Metformin and Lifestyle Changes to Prevent Dementia in Older Adults at Risk https://clinicaltrials.eu/trial/study-on-metformin-and-lifestyle-changes-to-prevent-dementia-in-older-adults-at-risk/ Wed, 29 Apr 2026 15:05:51 +0000 https://clinicaltrials.eu/trial/study-on-metformin-and-lifestyle-changes-to-prevent-dementia-in-older-adults-at-risk/ This clinical trial is focused on preventing cognitive decline and dementia in older adults who are at risk but currently do not have dementia or significant memory problems. The study will use a combination of a lifestyle-based program and a medication called Metformin Hydrochloride. Metformin is commonly used to help control blood sugar levels in people with diabetes, but in this study, it is being tested for its potential benefits in preventing dementia.

The purpose of the study is to see if a structured lifestyle program combined with Metformin can help maintain or improve cognitive function in older adults. Participants will be randomly assigned to either an active group receiving the structured lifestyle program and Metformin or a control group receiving a self-guided lifestyle program and a placebo. The lifestyle program includes guidance on diet, exercise, and other healthy habits. The study will last for 24 months, during which participants will be monitored for changes in their cognitive abilities and overall health.

Throughout the study, various aspects of health will be assessed, including memory, thinking skills, physical activity, diet, and quality of life. The trial aims to provide valuable insights into whether combining lifestyle changes with Metformin can effectively reduce the risk of developing dementia in older adults. Participants will be closely monitored to ensure their safety and well-being throughout the study period.

]]> Study on the Effects of Acetylsalicylic Acid and Cytisine for High-Risk Patients in Preventing Lung Cancer and Reducing Inflammation https://clinicaltrials.eu/trial/study-on-the-effects-of-acetylsalicylic-acid-and-cytisine-for-high-risk-patients-in-preventing-lung-cancer-and-reducing-inflammation/ Wed, 29 Apr 2026 15:05:43 +0000 https://clinicaltrials.eu/trial/study-on-the-effects-of-acetylsalicylic-acid-and-cytisine-for-high-risk-patients-in-preventing-lung-cancer-and-reducing-inflammation/ This clinical trial is focused on individuals at high risk of developing an inflammatory state and mortality from lung cancer, other cancers, and various causes. The study aims to evaluate the effectiveness of a multi-factor intervention in reducing inflammation. Participants will be given treatments that include Cardioaspirin (which contains acetylsalicylic acid) and Tabex (which contains cytisine). These medications are administered in the form of tablets taken orally.

The purpose of the study is to assess how these interventions can help reduce inflammation and improve overall health outcomes in high-risk individuals. The study will involve regular monitoring and assessments over a period of time to observe changes in health markers, such as inflammation levels and smoking habits. Participants will be randomly assigned to different groups, with some receiving the active medications and others receiving a placebo.

Throughout the study, participants will be encouraged to follow a healthy lifestyle, including adherence to the Mediterranean Diet and increased physical activity. The study will also track various health indicators, such as weight, waist circumference, and blood markers, to evaluate the overall impact of the interventions. The ultimate goal is to determine if these treatments can lead to a reduction in the incidence of lung cancer and improve the quality of life for those at high risk.

]]> Study on Denosumab to Prevent Breast Cancer in Women with BRCA1 Mutation https://clinicaltrials.eu/trial/study-on-denosumab-to-prevent-breast-cancer-in-women-with-brca1-mutation/ Wed, 29 Apr 2026 15:05:34 +0000 https://clinicaltrials.eu/trial/study-on-denosumab-to-prevent-breast-cancer-in-women-with-brca1-mutation/ This clinical trial is focused on the prevention of breast cancer in women who carry a specific genetic change known as the BRCA1 germline mutation. The study is investigating whether a medication called Denosumab, which is given as a solution for injection, can help prevent the development of breast cancer in these women. Denosumab is a type of protein-based medication that is already used for other medical conditions.

The purpose of the study is to see if Denosumab can reduce the risk of developing any type of breast cancer, including invasive breast cancer or a condition called DCIS (ductal carcinoma in situ), which is an early form of breast cancer. Participants in the study will receive either Denosumab or a placebo, and the study will compare the outcomes between these two groups. The study will also look at other health outcomes, such as the time it takes for any breast cancer to develop, the occurrence of other types of cancer, and the frequency of breast biopsies.

The study will take place over several years, with participants receiving regular injections and undergoing health assessments to monitor for any signs of breast cancer or other health changes. The goal is to gather information that could lead to new ways to prevent breast cancer in women with the BRCA1 mutation.

]]> Study on Preventing Early Respiratory Infections in Intubated Patients Using Ceftriaxone, a Cough Simulator, and Subglottic Secretion Aspiration https://clinicaltrials.eu/trial/study-on-preventing-early-respiratory-infections-in-intubated-patients-using-ceftriaxone-a-cough-simulator-and-subglottic-secretion-aspiration/ Wed, 29 Apr 2026 15:04:59 +0000 https://clinicaltrials.eu/trial/study-on-preventing-early-respiratory-infections-in-intubated-patients-using-ceftriaxone-a-cough-simulator-and-subglottic-secretion-aspiration/ This clinical trial is focused on preventing early respiratory tract infections in patients who are intubated due to a reduced level of consciousness from severe trauma, brain injury, stroke, cardiac arrest, or other causes. The study will explore the use of a short course of a systemic antibiotic called ceftriaxone, a device known as a Bionic Cough Simulator, and a method for removing secretions from the throat area called subglottic aspiration.

The purpose of the study is to compare the safety and effectiveness of these treatments in preventing infections in critically ill patients who are on a breathing machine. Participants will receive one or more of these treatments, and their health will be monitored for any severe side effects related to the devices, the antibiotic, or infections. The study will last for up to 14 days, during which the occurrence of respiratory infections like pneumonia and tracheobronchitis will be closely observed.

Throughout the study, researchers will also track other health outcomes, such as the duration of intubation, the length of stay in the intensive care unit, and the overall recovery of the patients. The study aims to provide valuable insights into the best ways to prevent infections in patients who require mechanical breathing support.

]]> Study on the Effect of Levobupivacaine in Reducing Chronic Pain After Open Inguinal Hernia Repair in Patients https://clinicaltrials.eu/trial/study-on-the-effect-of-levobupivacaine-in-reducing-chronic-pain-after-open-inguinal-hernia-repair-in-patients/ Wed, 29 Apr 2026 15:00:46 +0000 https://clinicaltrials.eu/trial/study-on-the-effect-of-levobupivacaine-in-reducing-chronic-pain-after-open-inguinal-hernia-repair-in-patients/ This clinical trial is focused on studying chronic postsurgical pain that can occur after undergoing an open inguinal hernia mesh repair. The treatment being investigated is a technique called the transversus abdominis plane (TAP) block, which involves using a local anesthetic named Levobupivacaine. This anesthetic is administered through a local injection to help manage pain. The purpose of the study is to compare the effects of administering the TAP block before the surgical incision (preincisional) versus after the surgical incision (postincisional) on the development of chronic pain following the surgery.

Participants in the study will undergo the open inguinal hernia mesh repair procedure, which is a common surgery to fix hernias in the groin area. The study will observe the patients for a period of three months after their surgery to assess the incidence of chronic pain. The goal is to determine if the timing of the TAP block can help prevent chronic pain and reduce the need for long-term use of pain-relief medications.

This study aims to provide valuable insights into pain management strategies for patients undergoing this type of hernia repair, potentially improving recovery experiences and outcomes. By understanding the impact of the TAP block’s timing, healthcare providers can better tailor pain management approaches to enhance patient comfort and reduce the risk of chronic pain after surgery.

]]> Study on the Safety of Salbutamol Inhalers with Propellants HFA-152a and HFA-134a for Adults with Asthma https://clinicaltrials.eu/trial/study-on-the-safety-of-salbutamol-inhalers-with-propellants-hfa-152a-and-hfa-134a-for-adults-with-asthma/ Wed, 29 Apr 2026 14:28:38 +0000 https://clinicaltrials.eu/trial/study-on-the-safety-of-salbutamol-inhalers-with-propellants-hfa-152a-and-hfa-134a-for-adults-with-asthma/ This clinical trial is focused on studying the safety and tolerability of a medication called salbutamol sulfate, which is commonly used to treat asthma. Asthma is a condition that affects the airways in the lungs, making it difficult to breathe. The study will compare two different types of inhalers that deliver salbutamol: one using a new propellant called HFA-152a and the other using the standard propellant HFA-134a. Both inhalers are designed to help relieve asthma symptoms by opening up the airways.

The purpose of the study is to evaluate the long-term safety of these inhalers over a period of three months. Participants in the study will be randomly assigned to use one of the two inhalers. Some participants may receive a placebo, which looks like the real inhaler but does not contain the active medication. The study will be conducted in a way that neither the participants nor the researchers know which inhaler each participant is using, to ensure unbiased results.

Throughout the study, participants will use their assigned inhaler as needed for asthma relief. They will attend regular check-ups to monitor their health and any side effects they may experience. The study aims to provide valuable information on the safety of the new propellant in the inhalers, which could lead to improved treatment options for people with asthma.

]]> Study on the Best Antithrombotic Therapy for Patients with Acute Venous Thromboembolism Using Tinzaparin Sodium and Drug Combination https://clinicaltrials.eu/trial/study-on-the-best-antithrombotic-therapy-for-patients-with-acute-venous-thromboembolism-using-tinzaparin-sodium-and-drug-combination/ Wed, 29 Apr 2026 14:24:37 +0000 https://clinicaltrials.eu/trial/study-on-the-best-antithrombotic-therapy-for-patients-with-acute-venous-thromboembolism-using-tinzaparin-sodium-and-drug-combination/ This clinical trial is focused on studying the best treatment options for patients with acute venous thromboembolism (VTE), a condition where blood clots form in the veins, often in the legs, and can travel to the lungs, causing a blockage known as a pulmonary embolism. The study will compare the effectiveness of using full-dose anticoagulant therapy alone versus combining it with antiplatelet therapy. Anticoagulants are medications that help prevent blood clots, while antiplatelets are used to prevent blood cells called platelets from clumping together, which can also lead to clots.

The medications being studied include INNOHEP (tinzaparin sodium), COUMADINE (warfarin sodium), Eliquis (apixaban), FRAGMINE (dalteparin sodium), Arixtra (fondaparinux sodium), SINTROM (acenocoumarol), HEPARINE CHOAY (heparin sodium), KARDEGIC (d,l-lysine acetylsalicylate), CALCIPARINE (heparin calcium), LOVENOX (enoxaparin sodium), Xarelto (rivaroxaban), and Plavix (clopidogrel). Some participants will receive a placebo, which is a substance with no active medication, to compare the effects of the actual treatments.

The purpose of the study is to determine if using full-dose anticoagulant therapy alone reduces the risk of significant bleeding compared to using it in combination with antiplatelet therapy. Participants will be monitored for up to 12 months to assess the occurrence of bleeding and other related health events. The study aims to provide insights into the safest and most effective treatment approach for patients with acute VTE who are also taking antiplatelet medications for other heart-related conditions.

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