The purpose of the study is to demonstrate that using lidocaine during surgery can decrease the need for pain relief medications, especially opioids, which are strong painkillers. Participants in the study will receive an injection of lidocaine at a concentration of 0.5% during their breast surgery. The study will monitor the level of pain experienced by participants at various times after the surgery, such as 1, 4, 12, 24, and 48 hours later.

The study will help understand if lidocaine can effectively reduce the incidence of acute postoperative pain, making recovery more comfortable for patients undergoing breast surgery. The trial is expected to continue until 2026, providing valuable insights into pain management for surgical patients.

The treatments being studied include belzutifan, which is taken as an oral film-coated tablet, and lenvatinib, which is taken as an oral capsule. Participants in the study will continue their current treatment regimen to monitor how the medications work over a longer period of time. The study will track overall survival, which refers to the length of time patients remain alive, and monitor any adverse events, which are side effects or unexpected medical problems that may occur during the treatment.

The goal of this study is to compare how well these two medications work in terms of safety and effectiveness when patients have hip replacement surgery that allows them to go home the same day. The study will look at how long it takes for feeling and movement to return after the numbing medication wears off, how many patients can go home on the same day as their surgery, and how long patients need to stay in the recovery area and hospital. Other things that will be measured include how much pain patients feel after surgery using a number scale, whether patients have difficulty urinating, if they experience nausea or vomiting, how much pain medication they need after surgery, how satisfied patients are with their care, blood pressure and heart rate during the procedure, how quickly the numbing effect starts, and whether the numbing medication works well enough during the surgery.

Patients in this study will receive one of the two numbing medications as a single injection before their hip replacement surgery. The study is designed so that neither the patients nor the doctors know which medication is being given until after the study is complete, which helps ensure fair results. The medications will be given at specific doses, with ropivacaine given at up to sixteen milligrams and bupivacaine given at up to thirteen and a half milligrams, both administered once on the day of surgery.

The purpose of the study is to evaluate how the body processes the medication and to monitor its safety. Researchers will observe how the drug is absorbed into the bloodstream, how it moves throughout the body, and how it is eventually eliminated. Additionally, the study will track how the body reacts to the treatment to ensure it is safe for use in this age group.

The purpose of the study is to compare how well patients recover within 24 hours after surgery when they receive pain relief with either tramadol or morphine as part of a combination approach to managing pain. Recovery will be measured using a questionnaire that asks about different aspects of how patients are feeling. Both morphine and tramadol are types of pain medications called opioids that work by affecting how the brain and body sense pain. Patients in the study will receive one of these medications during and after their surgery as part of their pain management plan.

During the study, patients will be asked to complete questionnaires at different times after surgery to assess their recovery and pain levels. The study will track how much pain medication is needed, how long patients stay in the recovery area and in the hospital, and whether any side effects occur such as nausea, vomiting, itching, or confusion. Patients will also be contacted at one month and three months after leaving the hospital to ask about ongoing pain medication use and whether they have developed long-lasting pain from the surgery. The study will look at satisfaction with pain management and assess the risk of medication misuse using specific evaluation tools.

The purpose of the study is to find out whether a lower dose or a medium dose of dexamethasone given through an intravenous injection, which means directly into a vein, is more effective at reducing the occurrence of rebound pain after foot surgery. Patients in this study will undergo open orthopedic foot surgery, which is a type of surgery where the surgeon makes an incision to access and repair structures in the foot. The surgery will be performed on an outpatient basis, meaning patients can go home the same day rather than staying overnight in the hospital. All patients will receive the nerve block for pain control during surgery, and they will also receive one of the two doses of dexamethasone to help prevent severe pain from returning suddenly when the nerve block wears off.

During the study, patients will have their pain levels checked at specific times after surgery through telephone calls at 24 hours, 48 hours, and 72 hours following the procedure. Pain will be measured using a scale where zero means no pain and ten means the worst pain imaginable. The study will track when patients first feel pain at the surgical site after the nerve block stops working, and will also monitor for any unwanted effects related to the medication, such as high blood sugar levels measured before patients leave the hospital, or problems with wound healing that might occur up to one month after surgery.

Women taking part in the study will be divided into two groups. One group will receive sufentanil before the procedure, while the other group will receive the standard treatment with midazolam. During the egg collection procedure, pain levels will be measured every two minutes using a pain scale where participants mark their pain level on a line. The study will also look at how satisfied participants are with their pain management about one day after the procedure, how much pain they feel in the recovery area and at home, whether they need to take additional pain medication at home, and whether they experience side effects such as nausea, vomiting, or breathing problems.

After the procedure, participants will be monitored in a recovery area before going home. They will be contacted about one day later to answer questions about their pain, satisfaction with pain management, any side effects, and any additional pain medication they took at home. The study will also collect information about the procedure itself, such as how long it took, how many eggs were collected, and certain hormone levels measured before and after the procedure. Information about whether pregnancy occurs will also be collected.

The purpose of the study is to evaluate the onset time and duration of a radial nerve block, which is a type of local anesthesia that targets a specific nerve to block pain. Participants will receive either the lidocaine injection or a placebo, and the study will compare the effects between two groups: those who regularly use opioids for chronic pain and those who do not. The study will observe how quickly the numbing effect begins and how long it lasts in both groups.

Participants in the study will be monitored to see the differences in how the nerve block works for each group. The study will measure the time it takes for the numbing to start and how long it lasts, as well as the effect on muscle movement. This research will help to better understand pain management in people who are tolerant to opioids, potentially leading to improved treatment options for managing postoperative pain.

The medications being studied include XYLOCAINE (which contains epinephrine bitartrate and lidocaine hydrochloride), ROPIVACAINE KABI (containing ropivacaine hydrochloride), MORPHINE, and PARACETAMOL B. BRAUN (containing paracetamol). These medications are used to manage pain and are administered in different forms, such as injections or infusions. Some patients may receive a placebo as part of the study to compare the effects of the actual medications.

The study will monitor patients for pain levels and the need for additional pain relief, such as morphine, in the hours and days following surgery. It will also track any side effects like nausea or vomiting and check for any signs of infection at the surgical site. The study will last until 2027, with patient recruitment starting in 2025. The goal is to determine if the echo-guided scalp blocks can effectively reduce the need for strong pain medications and improve recovery after brain surgery.

The purpose of the study is to determine if Botox is more effective than corticosteroids in treating persistent pain from surgical scars. Participants in the study will receive injections of either Botox or the corticosteroid. The study will monitor the participants’ pain levels and any changes they experience over a set period. The injections are given intradermally, which means they are administered just under the skin.

Throughout the study, participants’ pain will be assessed using a numerical rating scale, and additional questionnaires will be used to evaluate their overall pain experience and any changes in their condition. The study will also document any side effects that may occur. This research aims to provide better treatment options for individuals suffering from long-lasting pain after surgery.

The study will involve women who have undergone a cesarean section and will monitor their pain levels at different times after the surgery. The researchers will look at how well the pain is managed within the first six hours, as well as after 24 hours, 14 days, and even up to three months. They will also assess other factors like the use of pain medications, the occurrence of nausea and vomiting, and the quality of breastfeeding and bonding with the baby.

Participants in the study will receive either magnesium sulfate or a placebo through an IV infusion. The study aims to provide valuable information on whether magnesium sulfate can be an effective addition to pain management strategies for women recovering from a cesarean section. The findings could help improve recovery experiences and outcomes for new mothers.

Participants in the study will be randomly assigned to receive either etoricoxib, celecoxib, or a placebo. The study is designed to be double-masked, meaning neither the participants nor the researchers will know which treatment each participant is receiving, to ensure unbiased results. The trial will observe the effects of these medications over a short period, focusing on their ability to lessen pain and discomfort after the surgery.

The study aims to determine if one of these medications is more effective than the other in reducing postoperative pain. It is anticipated that those receiving etoricoxib may experience a greater reduction in pain compared to those receiving a placebo, based on the known properties of the drug. This research could help improve pain management strategies for patients undergoing wisdom tooth removal in the future.

Participants in the study will receive one of the treatments during their surgery. The study will monitor the amount of pain medication needed after surgery, as well as other factors like pain levels, recovery time, and overall quality of life. The trial will also look at how quickly patients can be discharged from the hospital and any complications that may arise, such as irregular heartbeats or delayed bowel function.

The goal of this research is to find the most effective way to manage pain after heart surgery, which could lead to better recovery experiences for patients. By comparing methadone with the more commonly used fentanyl and oxycodone, the study hopes to identify a treatment that reduces the need for additional pain medication and improves overall patient outcomes.

Participants in the study will receive either Esketamine or a placebo, both given through an intravenous infusion, which means the medication is delivered directly into the bloodstream. Another substance used in the study is Sodium Chloride, commonly known as salt water, which is often used in medical settings as a fluid for injections. The study will monitor the total amount of opioids used by patients in the first week after their surgery to see if Esketamine makes a difference.

In addition to tracking opioid use, the study will also look at other factors such as how long patients stay in the hospital, their quality of life, and any side effects they experience. Pain levels will be assessed using standard pain rating scales. The goal is to find out if Esketamine can help manage pain more effectively and improve recovery after surgery for those with drug-resistant temporal lobe epilepsy.

The purpose of the study is to explore whether using Tapentadol after surgery can help prevent the development of chronic pain in patients who have undergone inguinal hernia or knee replacement surgeries. Participants in the study will receive either Tapentadol or a placebo after their surgery. The study will monitor the development of chronic pain over the course of the first year following the surgery to determine the effectiveness of the treatment.

By participating in this study, researchers aim to gain a better understanding of how chronic postoperative pain develops and whether Tapentadol can be an effective treatment to prevent it. The study is designed to be double-blind, meaning neither the participants nor the researchers know who is receiving the actual medication or the placebo, ensuring unbiased results. The trial is expected to continue until early 2026.

The study aims to evaluate the effectiveness of two different nerve block techniques: Transversus Abdominis Plane block and Quadratus Lumborum block. These are methods where pain-relieving medication is injected near specific muscles in the abdomen to reduce pain during and after surgery. The medication will be administered through a technique called perineural use, which means it is placed around specific nerves.

During the study, patients will receive one of these nerve block treatments, and their pain levels will be monitored. The maximum daily dose of the pain medication is 675 mg/ml. Patients will be observed for pain control, need for additional pain medication, and overall recovery after surgery. The study will also track other factors such as nausea, bowel function, and overall satisfaction with the pain control method.

The purpose of the study is to compare this new approach to the traditional opioid-based treatment in terms of pain relief, recovery after surgery, and overall health outcomes. Participants will receive either the new treatment or the conventional treatment, which may include a placebo. The study will monitor various aspects of recovery, including pain levels, the amount of opioids used, and the patient’s ability to recover and return to normal activities. The study will also look at how this approach affects the patient’s confidence in managing unexpected events and their quality of life over time.

Throughout the study, participants will be observed at different intervals, such as immediately after surgery, during their hospital stay, and at several points after discharge, including 3, 6, 12, and 24 months later. The goal is to see if the opioid-sparing approach can provide effective pain management and improve recovery without the side effects associated with high opioid use. This research aims to offer better pain management strategies for patients undergoing obesity surgery, potentially leading to improved health outcomes and quality of life.

The purpose of the study is to determine if using locoregional analgesia can reduce persistent pain after surgery. Participants will be monitored for their pain levels using a simple pain scale three months after their surgery. The study will also look at other factors, such as the presence of pain at six and twelve months after surgery, any episodes of nausea or vomiting, and the amount of pain medication needed during and after surgery. The trial will last for a period of time, with regular check-ins to assess the participants’ pain and recovery progress.

By participating in this study, researchers hope to gather valuable information on how effective locoregional analgesia is in managing post-operative pain in children. This could lead to better pain management strategies for young patients undergoing similar surgeries in the future. The study will continue until enough data is collected to make a clear conclusion about the benefits of this pain relief method.

Participants in the study will receive sufentanil during their surgery, and the study will monitor their pain levels at different times: 24 hours, 48 hours, and three months after the surgery. The study will also look at how much pain medication is needed after surgery and how intense the pain is at three months. This will help researchers learn more about how to manage pain after surgery and improve recovery for future patients.

The study will take place over a period of time, with the aim of gathering information on how sufentanil affects pain management in abdominal surgeries that are not considered major. By understanding the connection between sufentanil use and chronic pain, the study hopes to find better ways to prevent long-term pain after surgery.

The purpose of the study is to determine if using nonsteroidal anti-inflammatory drugs (NSAIDs) can help reduce pain 24 hours after heart surgery. Participants in the study will receive one of the medications or a placebo. The study will monitor pain levels at rest and during activities like chest physiotherapy, which is a type of exercise to help improve breathing. Pain will be measured using a numerical rating scale, where patients rate their pain from 0 (no pain) to 10 (worst pain possible).

The study will last for a period of time after surgery, with pain assessments conducted daily from the first to the seventh day. Additional assessments will include checking for nausea, any lung complications, and chronic pain at 48 hours and three months after surgery. The quality of life will also be evaluated three months after surgery using a questionnaire. This trial aims to provide valuable insights into pain management for patients undergoing heart surgery.

The purpose of the study is to determine if patients experience less pain after surgery when they receive the PECS II Block with liposomal bupivacaine compared to levobupivacaine. The trial will involve patients who are having a single breast removed due to cancer. Participants will receive one of the two medications before their surgery, and their pain levels will be monitored after the procedure. The study will also look at other factors such as the need for additional pain medication, patient satisfaction, and any complications that may arise.

Throughout the study, patients will be observed to see how long they need to stay in the recovery room and when they can be discharged from the hospital. The trial will also assess if patients experience any long-term pain or require additional treatments for nausea and vomiting after surgery. The goal is to find the most effective way to manage pain and improve recovery for patients undergoing breast cancer surgery.

During the trial, participants will receive either the PENG block using a medication called Ropivacaine or a placebo, which in this case is Saline. Ropivacaine is a medication used to numb a specific area of the body to help manage pain. The PENG block involves injecting the medication near the nerves around the hip to provide pain relief after the surgery.

The study will monitor participants for 24 hours after their surgery to assess their pain levels and any other complications. This will help researchers understand how effective the PENG block is in managing pain compared to the placebo. The goal is to improve pain management techniques for patients undergoing hip surgery, potentially leading to better recovery experiences.

The purpose of the study is to find out if using genetic information can help doctors choose the best pain treatment for each patient, making it more effective and reducing side effects. Participants in the study will be randomly assigned to receive either the standard pain treatment or a treatment plan based on their genetic test results. This will help researchers understand if the genetic test can improve pain management.

During the study, participants will take the medications orally, which means they will swallow them as pills or capsules. The study will last for a short period, up to three days, which is typical for managing pain after surgery. By comparing the outcomes of the different treatment plans, the study aims to provide insights into whether genetic testing can be a useful tool in personalizing pain management for better results.

The purpose of the study is to determine if Aescuven can effectively reduce swelling, pain, and fluid buildup after meniscus surgery. Participants in the study will take four tablets of Aescuven daily, divided into two doses. The study will be conducted in a way that neither the participants nor the researchers know who is receiving the actual medication or the placebo, ensuring unbiased results. This type of study is known as a double-blind trial.

Throughout the study, participants will have several visits where their knee’s condition will be assessed. These assessments will include measuring the knee’s volume and circumference, checking the range of motion, and evaluating the skin temperature at the surgery site. The study will also track the amount of pain medication used by participants and their overall quality of life during the trial period. The study aims to provide valuable information on the potential benefits of using Aescuven for managing post-surgical symptoms in meniscus surgery patients.

The purpose of the study is to assess both the helpful and potentially harmful effects of taking ibuprofen for eight days after surgery. Participants will be randomly assigned to receive either ibuprofen or an identical capsule that does not contain the active medication, known as a placebo. The study will monitor for any serious health issues, such as heart problems or bleeding, within 90 days after surgery. It will also track any side effects related to ibuprofen, like stomach discomfort or diarrhea, and compare them to side effects from other pain medications, such as nausea or constipation.

Throughout the study, participants will keep a diary of their symptoms and complete a health-related quality of life questionnaire. This will help researchers understand how ibuprofen affects recovery and overall well-being after surgery. The study aims to provide valuable information on the safe use of ibuprofen in managing pain after hip and knee surgeries.

Participants in the study will receive either Clonidine or a placebo during their spine surgery. The study will monitor the amount of pain medication needed after surgery, as well as other factors like pain levels, sedation, nausea, and the time it takes for patients to be discharged from the recovery area. The study will also look at the length of the hospital stay and the amount of pain medication needed one month after surgery.

The trial is designed to provide valuable information on how Clonidine can be used to manage pain after spine surgery, potentially improving recovery and reducing the need for other pain medications. The study will run until August 2025, with recruitment having started in August 2023.