Procedural hypotension – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 10:37:32 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Procedural hypotension – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on the Effect of Norepinephrine Infusion for Managing Low Blood Pressure in Patients Undergoing Non-Cardiac Surgery https://clinicaltrials.eu/trial/study-on-the-effect-of-norepinephrine-infusion-for-managing-low-blood-pressure-in-patients-undergoing-non-cardiac-surgery/ Wed, 29 Apr 2026 15:01:36 +0000 https://clinicaltrials.eu/trial/study-on-the-effect-of-norepinephrine-infusion-for-managing-low-blood-pressure-in-patients-undergoing-non-cardiac-surgery/ This clinical trial is focused on studying the effects of a medication called norepinephrine, also known as noradrenaline, on managing low blood pressure, or hypotension, during surgeries that do not involve the heart. The trial aims to determine if using norepinephrine is better than the usual methods for controlling blood pressure during these types of surgeries.

Participants in the study will receive either an infusion of norepinephrine or standard blood pressure management during their surgery. The study will monitor the occurrence of low blood pressure during and shortly after the surgery. The goal is to see if norepinephrine can help maintain stable blood pressure more effectively than the standard approach.

Throughout the study, researchers will also observe other health outcomes, such as the time spent with low blood pressure during and after surgery, and any major complications related to blood flow, like heart injury, kidney problems, stroke, or infections. The study will also track how many days participants spend alive and at home within 30 days after their surgery. This research will help improve understanding of how to best manage blood pressure during non-heart-related surgeries.

]]> Study on Fluid Therapy and Noradrenaline for Low Blood Pressure in Breast Reconstruction Surgery Patients https://clinicaltrials.eu/trial/study-on-fluid-therapy-and-noradrenaline-for-low-blood-pressure-in-breast-reconstruction-surgery-patients/ Wed, 29 Apr 2026 14:26:50 +0000 https://clinicaltrials.eu/trial/study-on-fluid-therapy-and-noradrenaline-for-low-blood-pressure-in-breast-reconstruction-surgery-patients/ This clinical trial is focused on studying arterial hypotension, which is a condition where blood pressure is lower than normal, during a specific type of breast reconstruction surgery known as deep inferior epigastric perforator (DIEP) free flap surgery. The study will explore the effects of a treatment approach called goal-directed fluid therapy, which involves carefully managing the fluids given to patients during surgery to maintain optimal blood pressure and fluid balance.

Two treatments will be used in this study. The first is a solution called Plasma-Lyte® 148 (pH 7.4) solution for infusion, which contains a mix of important salts and minerals like magnesium chloride hexahydrate, potassium chloride, sodium chloride, sodium acetate trihydrate, and sodium gluconate. These substances help maintain the body’s fluid and electrolyte balance. The second treatment is a medication called noradrenaline (norepinephrine) 1 mg/ml concentrate for solution for infusion, which is used to help increase blood pressure by narrowing blood vessels.

The purpose of the study is to investigate how this fluid management strategy affects the amount of fluid given during surgery and its impact on the patient’s recovery. Participants will receive either the treatment or a placebo during their surgery. The study will monitor various factors, such as the total amount of fluid given during surgery, the amount of noradrenaline used, and the patient’s blood pressure and recovery in the intensive care unit. The study aims to provide valuable insights into improving care for patients undergoing DIEP free flap breast reconstruction.

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