Primary hypercholesterolaemia – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 10:34:17 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Primary hypercholesterolaemia – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on the Effect of Genetic Testing and Training on Muscle Side Effects in Patients Taking Statins for Cardiovascular Risk Prevention https://clinicaltrials.eu/trial/study-on-the-effect-of-genetic-testing-and-training-on-muscle-side-effects-in-patients-taking-statins-for-cardiovascular-risk-prevention/ Wed, 29 Apr 2026 14:56:55 +0000 https://clinicaltrials.eu/trial/study-on-the-effect-of-genetic-testing-and-training-on-muscle-side-effects-in-patients-taking-statins-for-cardiovascular-risk-prevention/ This clinical trial is focused on studying the effects of medications called statins, which are commonly used to manage cardiovascular risk. Cardiovascular risk refers to the likelihood of experiencing heart-related issues, and statins help by lowering cholesterol levels in the blood. The trial will involve several types of statins, including pravastatin sodium, atorvastatin, pitavastatin calcium, fluvastatin sodium, and rosuvastatin zinc. These medications are taken orally, meaning they are swallowed in pill form.

The purpose of the study is to evaluate whether using genetic information can help reduce muscle-related side effects in patients taking statins. Some people experience muscle pain or weakness when taking statins, and this study aims to see if genetic testing can help doctors choose the right statin for each patient to minimize these side effects. The study will compare two groups of patients: one group will receive statins based on standard medical practice, while the other group will have their statin prescribed based on genetic testing results. The study will follow participants for six months to observe any differences in muscle-related side effects between the two groups.

Participants in the study will be adults who need statins to manage their cardiovascular risk. They will be monitored for any muscle-related side effects during the first six months of treatment, with some participants being followed for up to a year or longer. The study aims to provide valuable insights into how genetic testing can be used to improve the safety and effectiveness of statin therapy in managing cardiovascular risk.

]]> Study on Managing High Cholesterol in Cardiovascular Disease Patients Using Inclisiran https://clinicaltrials.eu/trial/study-on-managing-high-cholesterol-in-cardiovascular-disease-patients-using-inclisiran/ Wed, 29 Apr 2026 14:22:52 +0000 https://clinicaltrials.eu/trial/study-on-managing-high-cholesterol-in-cardiovascular-disease-patients-using-inclisiran/ This clinical trial is focused on managing cholesterol levels in patients at high risk for heart disease. The study is investigating the effects of a medication called Leqvio, which contains the active substance inclisiran. This medication is administered as a solution for injection and is designed to help lower levels of low-density lipoprotein cholesterol (LDL-C), often referred to as “bad” cholesterol. The diseases being studied include primary hypercholesterolemia, which is a condition characterized by high cholesterol levels, and mixed dyslipidemia, which involves abnormal amounts of lipids in the blood, both of which can contribute to atherosclerotic cardiovascular disease.

The purpose of the study is to determine if a comprehensive and intensive lipid management program can effectively reduce LDL-C levels in patients. Participants in the study will receive either the medication or a placebo, and their cholesterol levels will be monitored over time. The study will also assess changes in heart health indicators, such as the amount of plaque in the arteries, using imaging techniques like computed tomography (CT) scans. Additionally, the study will evaluate changes in lifestyle, diet, and health behaviors that may impact cholesterol levels and overall heart health.

Throughout the study, participants will have regular visits to track their progress and any changes in their condition. The study aims to provide valuable insights into how intensive management of cholesterol can benefit patients with high cardiovascular risk, potentially leading to improved treatment strategies for managing cholesterol-related conditions.

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