Primary bilateral macronodular adrenal hyperplasia – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Thu, 28 May 2026 11:32:07 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Primary bilateral macronodular adrenal hyperplasia – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study of the effect of metyrapone in patients with mild Cushing syndrome caused by primary bilateral macronodular adrenal hyperplasia https://clinicaltrials.eu/trial/study-of-the-effect-of-metyrapone-in-patients-with-mild-cushing-syndrome-caused-by-primary-bilateral-macronodular-adrenal-hyperplasia/ Wed, 29 Apr 2026 15:09:17 +0000 https://clinicaltrials.eu/trial/study-of-the-effect-of-metyrapone-in-patients-with-mild-cushing-syndrome-caused-by-primary-bilateral-macronodular-adrenal-hyperplasia/ This study examines the effects of metyrapone on patients living with Primary Bilateral Macronodular Adrenal Hyperplasia. This condition occurs when the two adrenal glands, which are small organs located on top of the kidneys, develop many large lumps that cause them to produce too much cortisol. Too much of this hormone can lead to Cushing Syndrome, a condition that often results in hypertension (high blood pressure) and diabetes (high blood sugar levels).

The purpose of this study is to see if inhibiting the production of cortisol can help improve blood pressure and blood sugar control. Participants will be assigned to receive either metyrapone or a placebo. During the study, various health measurements will be taken to track changes in hormone levels, weight, and blood sugar levels over several months.

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