Preterm premature rupture of membranes – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:15:43 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Preterm premature rupture of membranes – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on Betamethasone Sodium Phosphate and Drug Combination for Pregnant Women with Preterm Premature Rupture of Membranes https://clinicaltrials.eu/trial/study-on-betamethasone-sodium-phosphate-and-drug-combination-for-pregnant-women-with-preterm-premature-rupture-of-membranes/ Wed, 29 Apr 2026 15:04:31 +0000 https://clinicaltrials.eu/trial/study-on-betamethasone-sodium-phosphate-and-drug-combination-for-pregnant-women-with-preterm-premature-rupture-of-membranes/ This clinical trial is focused on a condition known as preterm premature rupture of membranes (pPROM) in pregnancy. This condition occurs when the amniotic sac, which holds the baby and amniotic fluid, breaks earlier than expected, specifically before 37 weeks of pregnancy. The study aims to explore a personalized treatment approach to safely prolong pregnancy, improve outcomes for both the mother and the newborn, and reduce unnecessary use of antibiotics.

The trial will evaluate the effectiveness of a tailored treatment plan that includes specific antibiotics and steroids. The antibiotics being studied include gentamicin, benzylpenicillin, demeclocycline hydrochloride, and ampicillin combined with a beta-lactamase inhibitor. The steroid used in the study is dexamethasone. Additionally, magnesium sulfate is included for its neuroprotective properties. The treatment plan is based on the levels of a substance called IL-6 in the amniotic fluid, which is obtained through a procedure known as amniocentesis. This approach is compared to the standard treatment to see if it can help extend the pregnancy duration.

Participants in the study will receive either the tailored treatment or a standard treatment, which may include a placebo. The study will monitor how long the pregnancy lasts after the membranes rupture, as well as any short-term health effects on the mother and baby. The goal is to determine if the personalized treatment can effectively prolong pregnancy and improve health outcomes. The study will also look at the presence of certain infections and the microbiome, which is the collection of microorganisms in the body, in both the mother and the newborn.

]]> Study of oxytocin, dinoprostone, and misoprostol combination for active management in pregnant women with premature rupture of membranes https://clinicaltrials.eu/trial/study-on-the-effects-of-oxytocin-dinoprostone-and-mifepristone-in-pregnant-women-with-premature-rupture-of-membranes-prom/ Wed, 29 Apr 2026 15:02:37 +0000 https://clinicaltrials.eu/trial/study-on-the-effects-of-oxytocin-dinoprostone-and-mifepristone-in-pregnant-women-with-premature-rupture-of-membranes-prom/ This study focuses on pregnant women with premature rupture of membranes (PROM), a condition where the water breaks before labor begins. The study aims to determine if early induction of labor can reduce the need for breathing support in newborns compared to waiting for labor to start naturally.

The study will use several medications to help start labor: oxytocin, a hormone given through a vein that helps the uterus contract; dinoprostone, a medication used vaginally to prepare the cervix and induce labor; and misoprostol, a medication taken by mouth that also helps induce labor. Mifepristone may also be used to help prepare the body for labor.

During the study, women will be randomly assigned to either receive these medications to start labor right away or wait for labor to begin on its own. The study will track how many newborns need breathing support after birth, as well as monitor for other health outcomes in both mothers and babies. This includes checking for signs of infection, monitoring the pattern of uterine contractions, and keeping track of how long mothers and babies need to stay in the hospital.

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