Premature rupture of membranes – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 10:37:26 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Premature rupture of membranes – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on Nifedipine for Managing Preterm Premature Rupture of Membranes (PPROM) in Pregnant Women Before 34 Weeks https://clinicaltrials.eu/trial/study-on-nifedipine-for-managing-preterm-premature-rupture-of-membranes-pprom-in-pregnant-women-before-34-weeks/ Wed, 29 Apr 2026 15:01:26 +0000 https://clinicaltrials.eu/trial/study-on-nifedipine-for-managing-preterm-premature-rupture-of-membranes-pprom-in-pregnant-women-before-34-weeks/ This clinical trial is focused on studying the effects of a treatment for a condition known as preterm premature rupture of membranes (PPROM), which occurs when the water breaks too early in pregnancy, specifically before 34 weeks of gestation. The treatment being tested is a medication called nifedipine, which is taken as a prolonged-release tablet. The study also involves a comparison with a placebo, which is a substance with no active medication.

The purpose of the study is to determine if using nifedipine for a short period of 48 hours can help reduce the risks to the baby and mother when PPROM occurs between 22 and 33 weeks of pregnancy. Participants in the study will be randomly assigned to receive either the medication or the placebo, and neither the participants nor the researchers will know which one is being given, to ensure unbiased results.

The study will monitor several outcomes, including the health of the baby at birth and up to discharge from the hospital, as well as the health of the mother. It will also look at how long the pregnancy can be safely prolonged and the health of the baby at two years of age. The study aims to provide valuable information on managing PPROM to improve outcomes for both mothers and their babies.

]]> Study Comparing Balloon with Oxytocin and Oral Misoprostol for Inducing Labor in First-Time Mothers with Premature Rupture of Membranes at Term https://clinicaltrials.eu/trial/study-comparing-balloon-with-oxytocin-and-oral-misoprostol-for-inducing-labor-in-first-time-mothers-with-premature-rupture-of-membranes-at-term/ Wed, 29 Apr 2026 14:25:12 +0000 https://clinicaltrials.eu/trial/study-comparing-balloon-with-oxytocin-and-oral-misoprostol-for-inducing-labor-in-first-time-mothers-with-premature-rupture-of-membranes-at-term/ This clinical trial is focused on helping pregnant women who experience a condition known as premature rupture of membranes (PROM) at full term. PROM occurs when the water breaks before labor begins, which can lead to complications if not managed properly. The study is comparing two different methods to induce labor in women who have not given birth before and have an unfavorable cervix, which means the cervix is not yet ready for labor. The first method involves using a balloon catheter along with the hormone oxytocin, which is given intravenously to help start contractions. The second method uses a medication called misoprostol, taken orally, which is a synthetic form of a natural substance in the body that helps induce labor.

The purpose of the study is to determine which method is more effective in achieving a vaginal birth within 24 hours and to assess the satisfaction of the women with the induction process. Participants will be randomly assigned to one of the two methods. For those in the balloon and oxytocin group, a balloon catheter will be inserted, and oxytocin will be administered after six hours if needed. For those in the misoprostol group, a low dose of the medication will be given every two hours. The study will also collect feedback from participants about their experience using a survey before they leave the hospital.

The trial will monitor various outcomes, such as the time it takes to give birth, the level of discomfort during labor induction, and the overall experience of contractions. Other factors being studied include the duration from the rupture of membranes to the start of induction, the total dose of misoprostol received, and the rate of different types of delivery, including cesarean sections. The study aims to provide valuable information on the best approach to manage labor induction in cases of PROM, ensuring both the safety and satisfaction of the mother and baby.

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