Precocious puberty – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 10:32:52 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Precocious puberty – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on Metformin and Lifestyle Changes for Girls with Early Puberty and Overweight https://clinicaltrials.eu/trial/study-on-metformin-and-lifestyle-changes-for-girls-with-early-puberty-and-overweight/ Wed, 29 Apr 2026 14:29:49 +0000 https://clinicaltrials.eu/trial/study-on-metformin-and-lifestyle-changes-for-girls-with-early-puberty-and-overweight/ This clinical trial is focused on studying the effects of a medication called Metformin and lifestyle changes in young girls experiencing early puberty and who are overweight. Metformin is a medication commonly used to help control blood sugar levels and is being tested here for its potential to help with insulin sensitization, which means making the body more responsive to insulin, a hormone that helps control blood sugar. The study also includes a placebo, which is a substance with no active medication, to compare the effects of Metformin.

The purpose of the study is to understand how Metformin and lifestyle changes might affect the progression of puberty in these girls. The study will last for six months, during which participants will either receive Metformin or a placebo, and some will also participate in a lifestyle intervention. This intervention may include changes in diet and physical activity to see how these factors influence body composition and pubertal development. The main focus is on how these treatments affect bone age, which is a way to measure how quickly a child’s bones are maturing, as a marker of pubertal progression.

Throughout the study, researchers will monitor various aspects of the participants’ health, including changes in breast development, levels of sex hormones, and other metabolic markers. They will also assess body composition, fitness levels, blood pressure, heart rate, daily physical activity, and overall quality of life. The study aims to provide insights into how these interventions might help manage early puberty and its associated challenges in young girls.

]]> Study on Slowing Advanced Puberty in Girls Using Metformin, Pioglitazone, and Spironolactone https://clinicaltrials.eu/trial/study-on-slowing-advanced-puberty-in-girls-using-metformin-pioglitazone-and-spironolactone/ Wed, 29 Apr 2026 14:22:37 +0000 https://clinicaltrials.eu/trial/study-on-slowing-advanced-puberty-in-girls-using-metformin-pioglitazone-and-spironolactone/ This clinical trial is focused on studying girls with advanced puberty and accelerated bone maturation, as well as those with Polycystic Ovary Syndrome (PCOS). The treatment being tested is a medication called SPIOMET, which is a combination of three active substances: metformin, pioglitazone, and spironolactone. These substances are commonly used to manage conditions related to insulin resistance and hormonal imbalances. The purpose of the study is to determine if this combination can help slow down the rapid maturation process in young girls who have experienced low birth weight and high weight gain after birth.

Participants in the study will be randomly assigned to receive either the SPIOMET treatment or a placebo. The study will last for a period of 12 months, during which the participants will take the medication in tablet form. Throughout the study, various health parameters will be monitored, including bone development, weight, height, and hormone levels. The study aims to observe any changes in these parameters to assess the effectiveness of the treatment.

In addition to monitoring physical changes, the study will also evaluate the safety of the treatment by checking blood tests and other health markers. The goal is to ensure that the treatment is not only effective but also safe for the participants. The study will provide valuable insights into managing conditions related to early puberty and PCOS in young girls, potentially leading to better treatment options in the future.

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