Pouchitis – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:24:13 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Pouchitis – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study of guselkumab and dietary changes for patients with recurring or difficult-to-treat pouchitis https://clinicaltrials.eu/trial/study-of-guselkumab-and-dietary-changes-for-patients-with-recurring-or-difficult-to-treat-pouchitis/ Wed, 29 Apr 2026 15:09:34 +0000 https://clinicaltrials.eu/trial/study-of-guselkumab-and-dietary-changes-for-patients-with-recurring-or-difficult-to-treat-pouchitis/ This study focuses on Pouchitis, which is a condition involving inflammation of the pouch created in the digestive tract after certain surgeries. The research aims to evaluate the effectiveness of the drug guselkumab, given as a subcutaneous injection, either alone or when combined with specific changes in food intake. Participants may receive the medication through a pre-filled syringe containing a liquid solution.

During the study, individuals with recurring or difficult-to-treat symptoms will be monitored to see how they respond to the treatment. Some participants will receive guselkumab along with a dietary intervention, which means following specific eating guidelines, while others will only receive the medication. The course of the study involves regular check-ups over several weeks to observe changes in symptoms, the state of the intestinal lining, and levels of inflammation in the body.

]]> Study on GM-CSF, Fosfomycin, and Metronidazole for Treating Pouchitis in Ulcerative Colitis Patients Post-Surgery https://clinicaltrials.eu/trial/study-on-gm-csf-fosfomycin-and-metronidazole-for-treating-pouchitis-in-ulcerative-colitis-patients-post-surgery/ Wed, 29 Apr 2026 14:58:58 +0000 https://clinicaltrials.eu/trial/study-on-gm-csf-fosfomycin-and-metronidazole-for-treating-pouchitis-in-ulcerative-colitis-patients-post-surgery/ This clinical trial is focused on studying a condition called pouchitis, which can occur in patients who have had surgery for ulcerative colitis. The surgery, known as restorative ileal pouch anal anastomosis, is a procedure where a pouch is created from the small intestine to help with bowel movements. Pouchitis is an inflammation of this pouch, and it can cause symptoms similar to those of Crohn’s disease. The study aims to explore a new treatment approach using a combination of three medications: GM-CSF (also known as molgramostim), fosfomycin, and metronidazole. These medications will be applied directly to the pouch to see if they can help manage the condition by targeting bacterial imbalance and improving the immune response.

Participants in the study will receive the treatment over a specific period, and their health will be monitored to assess the safety and effectiveness of the treatment. The study will look at changes in the severity of pouchitis symptoms and other health indicators, such as white blood cell counts and liver enzymes, before and after the treatment. Researchers will also examine the diversity of bacteria in the pouch to understand how the treatment affects the microbial environment.

The study is designed to gather important information about the potential benefits and risks of this combined treatment for pouchitis. By participating, researchers hope to learn more about how these medications can be used to help patients with this condition, potentially leading to better treatment options in the future.

]]> Study on the Effectiveness and Safety of Vedolizumab for Children with Chronic Pouchitis Using a Drug Combination https://clinicaltrials.eu/trial/study-on-the-effectiveness-and-safety-of-vedolizumab-for-children-with-chronic-pouchitis-using-a-drug-combination/ Wed, 29 Apr 2026 14:27:58 +0000 https://clinicaltrials.eu/trial/study-on-the-effectiveness-and-safety-of-vedolizumab-for-children-with-chronic-pouchitis-using-a-drug-combination/ This clinical trial is focused on studying the treatment of Chronic Pouchitis in children. Chronic Pouchitis is a condition that affects the lining of a pouch created during surgery for ulcerative colitis, leading to inflammation and discomfort. The treatment being tested in this study is called Vedolizumab, which is administered through an intravenous infusion, meaning it is given directly into a vein. Vedolizumab is designed to help reduce inflammation in the digestive tract.

The purpose of this study is to evaluate how effective and safe Vedolizumab is for children with active chronic pouchitis. Participants in the study will receive Vedolizumab over a period of time, and their health will be monitored to see if the treatment helps them achieve clinical remission, which means a reduction in symptoms and inflammation. The study will also look at how well the body tolerates the medication and any potential side effects.

During the course of the study, participants will receive the medication and attend regular check-ups to assess their progress. The study aims to determine if Vedolizumab can help improve the quality of life for children suffering from chronic pouchitis by reducing symptoms and promoting healing in the affected area. This research is important for finding better treatment options for children with this condition.

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