Post procedural hypotension – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 10:30:55 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Post procedural hypotension – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on Fluid Therapy and Noradrenaline for Low Blood Pressure in Breast Reconstruction Surgery Patients https://clinicaltrials.eu/trial/study-on-fluid-therapy-and-noradrenaline-for-low-blood-pressure-in-breast-reconstruction-surgery-patients/ Wed, 29 Apr 2026 14:26:50 +0000 https://clinicaltrials.eu/trial/study-on-fluid-therapy-and-noradrenaline-for-low-blood-pressure-in-breast-reconstruction-surgery-patients/ This clinical trial is focused on studying arterial hypotension, which is a condition where blood pressure is lower than normal, during a specific type of breast reconstruction surgery known as deep inferior epigastric perforator (DIEP) free flap surgery. The study will explore the effects of a treatment approach called goal-directed fluid therapy, which involves carefully managing the fluids given to patients during surgery to maintain optimal blood pressure and fluid balance.

Two treatments will be used in this study. The first is a solution called Plasma-Lyte® 148 (pH 7.4) solution for infusion, which contains a mix of important salts and minerals like magnesium chloride hexahydrate, potassium chloride, sodium chloride, sodium acetate trihydrate, and sodium gluconate. These substances help maintain the body’s fluid and electrolyte balance. The second treatment is a medication called noradrenaline (norepinephrine) 1 mg/ml concentrate for solution for infusion, which is used to help increase blood pressure by narrowing blood vessels.

The purpose of the study is to investigate how this fluid management strategy affects the amount of fluid given during surgery and its impact on the patient’s recovery. Participants will receive either the treatment or a placebo during their surgery. The study will monitor various factors, such as the total amount of fluid given during surgery, the amount of noradrenaline used, and the patient’s blood pressure and recovery in the intensive care unit. The study aims to provide valuable insights into improving care for patients undergoing DIEP free flap breast reconstruction.

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