Polycystic ovarian syndrome – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:17:41 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Polycystic ovarian syndrome – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on Tirzepatide for Women with Overweight or Obesity and Polycystic Ovary Syndrome (PCOS) https://clinicaltrials.eu/trial/study-on-tirzepatide-for-women-with-overweight-or-obesity-and-polycystic-ovary-syndrome-pcos/ Wed, 29 Apr 2026 15:06:09 +0000 https://clinicaltrials.eu/trial/study-on-tirzepatide-for-women-with-overweight-or-obesity-and-polycystic-ovary-syndrome-pcos/ This clinical trial investigates the use of tirzepatide (LY3298176) in women with Polycystic Ovary Syndrome (PCOS) who are also experiencing overweight or obesity. PCOS is a hormonal disorder common among women of reproductive age that can cause irregular menstrual periods, excess male hormone levels, and small cysts on the ovaries. Women with PCOS often experience ovarian dysfunction, which includes menstrual irregularity and problems with ovulation.

The purpose of this study is to determine if tirzepatide is more effective than placebo in improving ovarian function in women with PCOS who have overweight or obesity. Tirzepatide is a medication that helps regulate blood sugar and can promote weight loss. The study will focus specifically on whether the medication can help normalize menstrual cycles in women with PCOS.

Participants will receive either tirzepatide or placebo through self-injection for 72 weeks (approximately 1.5 years). Throughout the study, researchers will track menstrual cycles, measure hormone levels in the blood, monitor changes in body weight and composition, and assess various health indicators related to metabolism and quality of life. Participants will need to avoid hormonal contraceptives during the study period and use alternative barrier methods for contraception.

]]> Study on Acupuncture and Metformin for Improving Insulin Sensitivity in Women with Polycystic Ovary Syndrome https://clinicaltrials.eu/trial/study-on-acupuncture-and-metformin-for-improving-insulin-sensitivity-in-women-with-polycystic-ovary-syndrome/ Wed, 29 Apr 2026 15:05:37 +0000 https://clinicaltrials.eu/trial/study-on-acupuncture-and-metformin-for-improving-insulin-sensitivity-in-women-with-polycystic-ovary-syndrome/ This clinical trial is focused on studying Polycystic Ovary Syndrome (PCOS), a condition that affects women’s hormone levels, leading to symptoms like irregular periods, acne, and excess hair growth. The study will explore the effects of two treatments: acupuncture and Metformin, a medication commonly used to improve insulin sensitivity, which is how well the body responds to insulin, a hormone that helps control blood sugar levels.

The purpose of the study is to determine how effective these treatments are in improving insulin sensitivity in women with PCOS. Participants will be divided into three groups: one group will receive acupuncture along with lifestyle management, another group will take Metformin along with lifestyle management, and the third group will only follow lifestyle management. Lifestyle management typically includes changes in diet and exercise habits. The study will last for about four months.

Throughout the study, participants will undergo various tests to measure changes in their insulin sensitivity and other related health markers. These tests will help researchers understand how each treatment affects the body and whether it can help manage symptoms of PCOS. The study aims to provide valuable insights into the potential benefits of acupuncture and Metformin for women with this condition.

]]> Study on Letrozole and Gonadotropins for Women with Polycystic Ovary Syndrome (PCOS) to Improve Live Birth Rates https://clinicaltrials.eu/trial/study-on-letrozole-and-gonadotropins-for-women-with-polycystic-ovary-syndrome-pcos-to-improve-live-birth-rates/ Wed, 29 Apr 2026 15:05:05 +0000 https://clinicaltrials.eu/trial/study-on-letrozole-and-gonadotropins-for-women-with-polycystic-ovary-syndrome-pcos-to-improve-live-birth-rates/ This clinical trial is focused on studying treatments for Polycystic Ovary Syndrome (PCOS), a condition that affects women’s hormone levels, often leading to irregular menstrual cycles and difficulty in getting pregnant. The study will compare two different treatments to help women with PCOS who wish to become pregnant. The first treatment involves continuing the use of letrozole, a medication taken orally in the form of a film-coated tablet. The second treatment involves switching to gonadotropins, which are hormones used to stimulate the ovaries and are administered through injections. The specific types of gonadotropins used in this study are human menopausal gonadotropins and follitropin alfa.

The purpose of the study is to determine which treatment is more effective in improving the chances of having a live birth. Participants will be randomly assigned to either continue with letrozole or switch to gonadotropins. The study will monitor the participants over a period of up to eight months to see if they become pregnant and have a live birth. During this time, the study will also look at other outcomes such as the number of pregnancies, any pregnancy complications, and the overall health and well-being of the participants.

Participants will be asked to keep a medication diary and complete questionnaires about their quality of life and mental health at different points during the study. The study will also assess the cost-effectiveness of the treatments by considering the costs involved and the quality of life of the participants. The goal is to provide valuable information that can help improve treatment options for women with PCOS who are trying to conceive.

]]> Study on Metformin and Metformin Hydrochloride for Overweight Adults with Polycystic Ovary Syndrome https://clinicaltrials.eu/trial/study-on-metformin-and-metformin-hydrochloride-for-overweight-adults-with-polycystic-ovary-syndrome/ Wed, 29 Apr 2026 15:03:16 +0000 https://clinicaltrials.eu/trial/study-on-metformin-and-metformin-hydrochloride-for-overweight-adults-with-polycystic-ovary-syndrome/ This clinical trial is focused on studying the effects of the medication Metformin in individuals with Polycystic Ovary Syndrome (PCOS). PCOS is a condition that affects women’s hormone levels, leading to various symptoms such as irregular menstrual cycles, excess hair growth, and potential fertility issues. The study will compare two different daily doses of Metformin, 1500 mg and 2250 mg, to determine their effectiveness in managing the symptoms and biochemical markers associated with PCOS.

The purpose of the study is to find out if a lower dose of Metformin is as effective as a higher dose in improving health outcomes for women with PCOS. Participants will take the medication in the form of tablets, which are to be taken orally. The study will last for a period of 48 weeks, during which participants will be monitored for changes in weight, hormone levels, and any side effects such as nausea or abdominal pain. The study will also assess the impact of Metformin on menstrual regularity and overall quality of life.

Throughout the study, various health indicators will be measured, including weight, hormone levels like testosterone, and metabolic markers such as fasting glucose and insulin levels. The study aims to provide valuable insights into the optimal use of Metformin for managing PCOS, potentially leading to improved treatment strategies for women affected by this condition.

]]> Study on the Effects of Spironolactone, Pioglitazone, and Metformin for Adolescent Girls and Young Women with Polycystic Ovary Syndrome (PCOS) https://clinicaltrials.eu/trial/study-on-the-effects-of-spironolactone-pioglitazone-and-metformin-for-adolescent-girls-and-young-women-with-polycystic-ovary-syndrome-pcos/ Wed, 29 Apr 2026 14:57:49 +0000 https://clinicaltrials.eu/trial/study-on-the-effects-of-spironolactone-pioglitazone-and-metformin-for-adolescent-girls-and-young-women-with-polycystic-ovary-syndrome-pcos/ This clinical trial is focused on studying a condition known as polycystic ovary syndrome (PCOS), which affects adolescent girls and young adult women. PCOS is a common hormonal disorder that can cause irregular menstrual cycles, excess hair growth, acne, and sometimes difficulty with fertility. The study is testing a treatment called SPIOMET, which is a combination of three medications: spironolactone, pioglitazone, and metformin. These medications are taken in tablet form and are designed to help manage the symptoms of PCOS by normalizing ovulation, which is the release of eggs from the ovaries.

The purpose of the study is to evaluate how effective and safe SPIOMET is for treating PCOS in young women. Participants in the study will be randomly assigned to receive either the SPIOMET tablets or a placebo. The study will last for a period of time during which participants will take the medication and attend regular check-ups to monitor their health and the effects of the treatment. The study aims to see if SPIOMET can help regulate menstrual cycles and improve other symptoms associated with PCOS.

Throughout the study, various health indicators will be monitored, including weight, height, and hormone levels. Participants will also be asked about their experiences with the medication, including any side effects they may encounter. The study will help determine if SPIOMET is a viable treatment option for young women with PCOS, potentially offering a new way to manage this condition.

]]> Study on Pregnancy Rates in Women with Polycystic Ovary Syndrome Using Letrozole and Gonadotropins https://clinicaltrials.eu/trial/study-on-pregnancy-rates-in-women-with-polycystic-ovary-syndrome-using-letrozole-and-gonadotropins/ Wed, 29 Apr 2026 14:26:36 +0000 https://clinicaltrials.eu/trial/study-on-pregnancy-rates-in-women-with-polycystic-ovary-syndrome-using-letrozole-and-gonadotropins/ This clinical trial is focused on studying the effectiveness of two different treatments for women with Polycystic Ovary Syndrome (PCOS), a condition that affects the ovaries and can lead to fertility issues. The study compares the use of a medication called Letrozole with a group of medications known as gonadotropins, which include GONAL-f, Ovaleap, Puregon, and Bemfola. These treatments are used to stimulate the ovaries in preparation for artificial insemination, a procedure that helps achieve pregnancy.

The purpose of the study is to determine if Letrozole can be an effective alternative to gonadotropins in terms of pregnancy rates and live birth rates for women undergoing artificial insemination. Participants in the study will receive either Letrozole or one of the gonadotropins for a period of up to 21 days. The study will monitor the number of pregnancies achieved, as well as the number of live births resulting from the treatments. Additionally, the study will observe other factors such as the number of follicles (small sacs in the ovaries) that develop, any cancellations due to lack of response or over-response to the treatment, and any side effects like insulin resistance or gestational diabetes.

Throughout the study, participants will undergo regular check-ups, including ultrasounds to monitor the development of follicles and blood tests to assess hormone levels. The study aims to provide valuable information on the effectiveness and safety of these treatments for women with PCOS who are seeking to become pregnant through artificial insemination.

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