Poisoning – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Thu, 28 May 2026 11:28:43 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Poisoning – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on Reduction of Toxicant Levels in Blood through Combined Digestive Decontamination with Activated Charcoal and Intestinal Purge for Intubated Patients with Major Poisoning in Intensive Care https://clinicaltrials.eu/trial/study-on-reduction-of-toxicant-levels-in-blood-through-combined-digestive-decontamination-with-activated-charcoal-and-intestinal-purge-for-intubated-patients-with-major-poisoning-in-intensive-care/ Wed, 29 Apr 2026 15:06:11 +0000 https://clinicaltrials.eu/trial/study-on-reduction-of-toxicant-levels-in-blood-through-combined-digestive-decontamination-with-activated-charcoal-and-intestinal-purge-for-intubated-patients-with-major-poisoning-in-intensive-care/ This study involves patients who have been intoxicated by functional toxicants (substances that affect bodily functions, such as psychotropic or cardiotropic drugs) and are receiving care in an intensive care unit while on a breathing machine (intubated). The purpose is to determine if using a combination of activated charcoal (a substance that can bind to toxins in the digestive system) plus an intestinal purge (a method to clear the intestines) is more effective at reducing the amount of toxic substances in the blood compared to standard care.

The study will measure how much the level of toxic substances in the blood decreases over time (at 24, 48, 72, and 96 hours) after treatment begins. Researchers will also track how many days patients survive without needing mechanical breathing support or intensive care, as well as any side effects that might occur such as vomiting, pneumonia, abdominal pain, diarrhea, or allergic reactions.

]]> Study on Detecting Sodium Oxybate in Intoxication Cases Using Sodium Oxybate, Sodium Chloride, and Paracetamol in Healthy Volunteers https://clinicaltrials.eu/trial/study-on-detecting-sodium-oxybate-in-intoxication-cases-using-sodium-oxybate-sodium-chloride-and-paracetamol-in-healthy-volunteers/ Wed, 29 Apr 2026 15:05:38 +0000 https://clinicaltrials.eu/trial/study-on-detecting-sodium-oxybate-in-intoxication-cases-using-sodium-oxybate-sodium-chloride-and-paracetamol-in-healthy-volunteers/ This clinical trial is focused on studying the detection of Gamma-Hydroxybutyrate (GHB), a substance sometimes involved in cases of intoxication, such as drug-facilitated crimes. The study aims to improve methods for detecting GHB in the body by identifying potential biomarkers, which are substances that can indicate the presence of GHB for a longer period than GHB itself. The trial involves healthy volunteers who will be given sodium oxybate, an oral solution that is chemically similar to GHB, to help researchers understand how long these biomarkers can be detected in the body.

Participants in the study will receive either the active treatment, which is sodium oxybate, or a placebo. The study will also involve the use of sodium chloride and paracetamol as part of the research process. Sodium chloride is a common salt solution, and paracetamol is a widely used pain reliever. The purpose of the study is to see how long the biomarkers can be detected in different body fluids and tissues, such as blood, urine, oral fluid, hair, and even dental calculus, which is the hardened plaque on teeth.

The study will monitor various aspects, including the concentration of GHB and the identified biomarkers in these samples over time. Additionally, the study will assess the effects of the drug on memory and physical appearance shortly after intake. This research is important for developing better ways to detect GHB in situations where it may have been used without a person’s knowledge, helping to improve safety and justice in such cases.

]]> Study on Detecting Nitrous Oxide in Healthy Volunteers Using Nitrous Oxide and Oxygen to Help Victims of Nitrous Oxide Intoxication https://clinicaltrials.eu/trial/study-on-detecting-nitrous-oxide-in-healthy-volunteers-using-nitrous-oxide-and-oxygen-to-help-victims-of-nitrous-oxide-intoxication/ Wed, 29 Apr 2026 15:05:28 +0000 https://clinicaltrials.eu/trial/study-on-detecting-nitrous-oxide-in-healthy-volunteers-using-nitrous-oxide-and-oxygen-to-help-victims-of-nitrous-oxide-intoxication/ This clinical trial is focused on studying the effects of nitrous oxide, commonly known as “laughing gas,” in healthy volunteers. The study aims to understand how long nitrous oxide can be detected in the body after exposure. This research is important for helping victims of crimes involving nitrous oxide. The study will also involve the use of paracetamol, a mild pain reliever, and oxygen, a gas essential for breathing, to support the research process.

The main purpose of the study is to measure the concentration of nitrous oxide in the blood after exposure and determine how long it remains detectable. Participants will inhale nitrous oxide, and researchers will monitor how long it takes for the gas to no longer be present in the blood, breath, and other bodily fluids. The study will also check if routine screening methods can detect nitrous oxide and related markers in the body.

Participants in the study will be healthy adults who will provide informed consent. They will be monitored closely to ensure their safety throughout the study. The trial will help improve understanding of nitrous oxide exposure and its detection, which can be crucial in forensic investigations. The study is expected to continue until 2027, with recruitment starting in late 2024.

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