Peripheral venous disease – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 05 Jun 2026 10:55:48 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Peripheral venous disease – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study to evaluate the efficacy and safety of personalized tissue engineered veins in patients with severe chronic venous insufficiency https://clinicaltrials.eu/trial/study-to-evaluate-the-efficacy-and-safety-of-personalized-tissue-engineered-veins-in-patients-with-severe-chronic-venous-insufficiency/ Thu, 30 Apr 2026 13:08:54 +0000 https://clinicaltrials.eu/trial/study-to-evaluate-the-efficacy-and-safety-of-personalized-tissue-engineered-veins-in-patients-with-severe-chronic-venous-insufficiency/ This study focuses on individuals living with Chronic Venous Insufficiency, a condition where the veins have trouble sending blood from the limbs back to the heart, often leading to swelling or skin issues. The research aims to evaluate the efficacy and safety of a Personalized Tissue Engineered Vein, referred to as P-TEV. This treatment involves the implantation of a special graft made from decellularised allogeneic vein tissue, which is biological material from a donor that has had its cells removed to prevent rejection, combined with a functional valve and the patient’s own blood.

Participants in the study will receive either the P-TEV graft or a control treatment. Following the procedure, the progress of the condition and the healing of any ulcers, which are open sores on the skin, will be monitored over a period of time. The study will observe how well the new vein valves work and how much the physical symptoms and signs of the disease improve through regular check-ups using ultrasound imaging to look at blood flow.

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