Perioperative analgesia – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:24:02 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Perioperative analgesia – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study of lidocaine hydrochloride to reduce side effects from pain medication in patients undergoing open liver surgery https://clinicaltrials.eu/trial/study-of-lidocaine-hydrochloride-to-reduce-side-effects-from-pain-medication-in-patients-undergoing-open-liver-surgery/ Wed, 29 Apr 2026 15:09:24 +0000 https://clinicaltrials.eu/trial/study-of-lidocaine-hydrochloride-to-reduce-side-effects-from-pain-medication-in-patients-undergoing-open-liver-surgery/ This study focuses on patients undergoing an open hepatectomy, which is a major surgical procedure to remove a portion of the liver. The research aims to compare the effects of an infusion of lidocaine hydrochloride with a placebo on side effects caused by opioids, which are strong pain medications, following the surgery. Potential complications being monitored include postoperative nausea and vomiting, hypoxemia, which is a condition where there is not enough oxygen in the blood, and postoperative ileus, a temporary lack of normal muscle contractions in the intestines that prevents the passage of food or gas.

Participants in the study will receive either lidocaine hydrochloride or sodium chloride through an intravenous infusion, meaning the substance is delivered directly into a vein. The study period covers the time around the surgery and the first 48 hours after the breathing tube is removed. Various factors such as pain levels, the amount of pain medication used, the length of time spent in the hospital, and the risk of other issues like pneumonia or acute kidney insufficiency will be observed during the recovery process.

]]> Study on the Emotional Effects of Morphine, Oxycodone, and Fentanyl Before Surgery in Healthy or Mildly Ill Patients https://clinicaltrials.eu/trial/study-on-the-emotional-effects-of-morphine-oxycodone-and-fentanyl-before-surgery-in-healthy-or-mildly-ill-patients/ Wed, 29 Apr 2026 14:57:48 +0000 https://clinicaltrials.eu/trial/study-on-the-emotional-effects-of-morphine-oxycodone-and-fentanyl-before-surgery-in-healthy-or-mildly-ill-patients/ This clinical trial is focused on understanding the effects of certain medications used before surgery. The study involves patients who are generally healthy or have mild diseases, as determined by a doctor. The medications being studied are three types of opioids: morphine, oxycodone, and fentanyl. These drugs are commonly used to manage pain during surgical procedures. The trial also includes a group receiving a placebo, which is a substance with no active medication.

The main goal of the study is to observe and compare how these medications affect the feelings and emotions of patients before they undergo general anesthesia for surgery. Participants will receive one of the three opioids in specific doses through an injection. The study will monitor how the patients feel after receiving the medication, focusing on their emotional state and any sensations they experience. This will help researchers understand the different effects these opioids have on patients’ feelings and emotions.

Throughout the study, participants will be asked to rate their feelings using a simple scale. This includes how good, anxious, or relaxed they feel, as well as any pain they might experience. The study will also look at other effects, such as heart rate changes, to gather more information about how these medications work. By comparing the results from different groups, the study aims to provide insights into the emotional effects of these commonly used opioids in a surgical setting.

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