Perineal injury – European Clinical Trials Information Network

Comparing Lidocaine-Prilocaine Cream and Lidocaine Injection for First-Degree Perineal Tear Repair in Women

Wed, 29 Apr 2026 15:01:29 +0000

This clinical trial is focused on studying the treatment of first-degree perineal tears, which are small tears that can occur in the area between the vagina and anus during childbirth. The study will compare two different methods of pain relief used during the repair of these tears. One method involves using a cream called EMLA, which contains two active substances, lidocaine and prilocaine. This cream is applied directly to the skin. The other method uses an injection of lidocaine hydrochloride, which is a solution injected into the area to numb it.

The purpose of the study is to compare how effective these two methods are in managing pain during the repair of the tear and in the two hours following childbirth. Participants in the study will receive either the cream or the injection, and their pain levels will be monitored and recorded. The study aims to provide insights into which method offers better pain relief for women experiencing first-degree perineal tears.

Throughout the study, participants will be observed to assess their pain levels and the characteristics of the tear, as well as other factors related to childbirth and the postpartum period. This includes monitoring the onset of labor, any alternative pain management therapies used, and the practice of skin-to-skin contact with the newborn. The study will also consider the characteristics of the newborn, such as weight and sex, and the mother’s age and number of previous births. The trial is expected to run until May 2025.

Study on Amoxicillin and Clavulanic Acid to Prevent Infection in Women with Obstetric Perineal Tear

Wed, 29 Apr 2026 14:24:54 +0000

This clinical trial is focused on studying the effects of oral antibiotics on preventing infections and wound complications after an obstetric perineal tear, which is a type of injury that can occur during childbirth. The treatment being tested is a medication called Bioclavid, which contains two active ingredients: amoxicillin and clavulanic acid. These are commonly used antibiotics that help fight bacterial infections. The study will compare the effects of this medication to a placebo, which is a substance with no active ingredients, to see if the antibiotics can reduce the risk of infection and help the wound heal better.

The purpose of the study is to determine whether taking three doses of these oral antibiotics can lower the chances of developing an infection or experiencing wound separation after a perineal tear. Participants in the study will be randomly assigned to receive either the antibiotics or the placebo. The study is designed to be double-blinded, meaning neither the participants nor the researchers will know who is receiving the actual medication or the placebo, to ensure unbiased results.

Throughout the study, researchers will monitor the participants for any signs of infection or wound complications. They will also check for any other issues that might arise, such as incontinence, pelvic prolapse, pain, or sexual dysfunction, both one week and one year after the treatment. The study aims to provide valuable information on whether antibiotics can be an effective way to prevent complications after childbirth-related perineal tears.

Study on Patient-Controlled Sedation with Propofol for Women Undergoing Repair of Obstetric Perineal Tears Using Ropivacaine, Lidocaine, and Mepivacaine

Wed, 29 Apr 2026 14:24:40 +0000

This clinical trial is focused on improving the experience of women undergoing repair for obstetric perineal lacerations, which are tears that can occur during childbirth. The study is investigating whether adding patient-controlled sedation with a medication called propofol can help reduce pain and discomfort during the procedure. Propofol is an intravenous anesthetic, meaning it is administered through a vein to help with sedation. The standard treatment involves a pudendal nerve block, which is a type of local anesthesia used to numb the area.

In addition to propofol, the study will also involve the use of local anesthetics such as ropivacaine, lidocaine, and mepivacaine. These medications are used to numb specific areas and help manage pain during the repair process. Ropivacaine and mepivacaine are administered through injection, while lidocaine can be applied topically. The purpose of the study is to see if the addition of propofol to these standard treatments can improve the overall experience for patients by reducing pain and discomfort.

Participants in the study will have the opportunity to control their own sedation using a device that administers propofol as needed. This allows them to manage their level of comfort during the procedure. The study will also look at other factors such as anxiety before the procedure, the time it takes to complete the repair, and the ability to have skin-to-skin contact with the baby during the repair. The goal is to gather information on how these treatments affect the patient’s experience and recovery after childbirth.