Pancreatic fistula – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 10:35:46 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Pancreatic fistula – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on Botulinum Toxin Type A to Prevent Pancreatic Fistulas in Patients Undergoing Distal Pancreatectomy https://clinicaltrials.eu/trial/study-on-botulinum-toxin-type-a-to-prevent-pancreatic-fistulas-in-patients-undergoing-distal-pancreatectomy/ Wed, 29 Apr 2026 14:59:03 +0000 https://clinicaltrials.eu/trial/study-on-botulinum-toxin-type-a-to-prevent-pancreatic-fistulas-in-patients-undergoing-distal-pancreatectomy/ This clinical trial is focused on studying the prevention of a condition known as postoperative pancreatic fistulas, which can occur after surgery on the pancreas. The pancreas is an organ in the body that helps with digestion and blood sugar regulation. A pancreatic fistula is a complication where digestive juices leak from the pancreas after surgery. The treatment being tested in this study is an injection of Botulinum toxin (BOTOX®), a substance that is commonly known for its use in cosmetic procedures but is also used in various medical treatments.

The purpose of this study is to explore whether injecting BOTOX® into a specific muscle called the sphincter of Oddi, which controls the flow of digestive juices, can safely and effectively prevent these fistulas from forming after a type of surgery called a distal pancreatectomy. This surgery involves removing part of the pancreas. The study will involve a series of steps where participants will receive the BOTOX® injection before their surgery, and researchers will monitor them to see if the treatment helps reduce the occurrence of pancreatic fistulas.

Participants in the study will undergo the BOTOX® injection before their scheduled surgery, and their recovery will be closely observed to assess the safety and feasibility of this approach. The study aims to determine if this method can be completed successfully in most patients and to evaluate its impact on reducing the risk of developing pancreatic fistulas after surgery. The findings from this study could potentially lead to improved outcomes for patients undergoing pancreatic surgery in the future.

]]> Study on Botulinum Toxin Injection to Prevent Pancreatic Fistula in Patients Undergoing Distal Pancreatectomy https://clinicaltrials.eu/trial/study-on-botulinum-toxin-injection-to-prevent-pancreatic-fistula-in-patients-undergoing-distal-pancreatectomy/ Wed, 29 Apr 2026 14:23:00 +0000 https://clinicaltrials.eu/trial/study-on-botulinum-toxin-injection-to-prevent-pancreatic-fistula-in-patients-undergoing-distal-pancreatectomy/ This clinical trial is focused on studying the prevention of a condition known as postoperative pancreatic fistula, which can occur after surgery on the pancreas. A pancreatic fistula is a complication where digestive juices leak from the pancreas, potentially leading to further health issues. The study will use a treatment involving an injection of botulinum toxin, specifically a form called IncobotulinumtoxinA or NT 201, which is commonly known as XEOMIN. This treatment is being tested to see if it can help prevent the development of pancreatic fistulas after surgery.

The purpose of the study is to evaluate how effective the botulinum toxin injection is in preventing pancreatic fistulas in the three months following a type of surgery called a distal pancreatectomy. This surgery involves removing part of the pancreas and is sometimes performed with or without the removal of the spleen. Participants in the study will receive either the botulinum toxin injection or a placebo during their surgery. The study will monitor participants for any signs of pancreatic fistula and other potential complications after their surgery.

Throughout the study, researchers will observe the participants for any side effects related to the botulinum toxin injection and will assess various outcomes, such as the duration of hospital stays, any additional procedures needed, and overall recovery. The study aims to provide valuable information on whether this treatment can improve recovery and reduce complications for patients undergoing pancreatic surgery.

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