Otitis media – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Tue, 23 Jun 2026 04:03:38 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Otitis media – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Comparison of amoxicillin, amoxicillin-clavulanate, and placebo for the treatment of middle ear infection in children https://clinicaltrials.eu/trial/comparison-of-amoxicillin-amoxicillin-clavulanate-and-placebo-for-the-treatment-of-middle-ear-infection-in-children/ Wed, 29 Apr 2026 15:09:13 +0000 https://clinicaltrials.eu/trial/comparison-of-amoxicillin-amoxicillin-clavulanate-and-placebo-for-the-treatment-of-middle-ear-infection-in-children/ This study is being conducted to compare different treatment options for Acute Otitis Media, which is a common type of ear infection. The research will evaluate the effectiveness of amoxicillin, a type of antibiotic, compared to amoxicillin combined with clavulanic acid, and a placebo.

During the study, participants will be assigned to receive one of the three different options. The treatment is provided as an oral suspension, which is a liquid medicine taken by mouth. The process involves monitoring the condition of the children over a period of time to see how they respond to the different medications.

]]> Study on Dupilumab for Patients with Chronic Rhinosinusitis with Nasal Polyps and Eosinophilic Otitis Media https://clinicaltrials.eu/trial/study-on-dupilumab-for-patients-with-chronic-rhinosinusitis-with-nasal-polyps-and-eosinophilic-otitis-media/ Wed, 29 Apr 2026 15:00:32 +0000 https://clinicaltrials.eu/trial/study-on-dupilumab-for-patients-with-chronic-rhinosinusitis-with-nasal-polyps-and-eosinophilic-otitis-media/ This clinical trial is focused on studying the effects of a medication called Dupilumab on patients who have two specific conditions: chronic rhinosinusitis with nasal polyps and eosinophilic otitis media. Chronic rhinosinusitis with nasal polyps is a long-term inflammation of the sinuses that leads to the growth of polyps, which are small, non-cancerous swellings. Eosinophilic otitis media is a type of ear inflammation characterized by the presence of a high number of eosinophils, which are a type of white blood cell. The medication being tested, Dupilumab, is administered as a solution for injection using a pre-filled pen.

The purpose of this study is to understand how Dupilumab affects ear symptoms and hearing function in patients with these conditions. Participants in the study will receive Dupilumab through subcutaneous injection, which means the medication is injected under the skin. The study will observe changes in symptoms and hearing over a period of time, specifically looking at how these change from the start of the treatment to 6 or 12 months later. Participants will be asked to complete questionnaires about their symptoms and undergo hearing tests to track any improvements or changes.

Throughout the study, researchers will monitor the participants’ progress by comparing their initial condition with their condition after receiving Dupilumab for several months. This will help determine the effectiveness of the treatment in managing symptoms related to chronic rhinosinusitis with nasal polyps and eosinophilic otitis media. The study aims to provide valuable insights into how Dupilumab can potentially improve the quality of life for individuals suffering from these conditions.

]]> Study on Meniere’s Disease: Comparing Methylprednisolone and Placebo for Patients with Unilateral Meniere’s Disease https://clinicaltrials.eu/trial/study-on-menieres-disease-comparing-methylprednisolone-and-placebo-for-patients-with-unilateral-menieres-disease/ Wed, 29 Apr 2026 14:24:16 +0000 https://clinicaltrials.eu/trial/study-on-menieres-disease-comparing-methylprednisolone-and-placebo-for-patients-with-unilateral-menieres-disease/ This clinical trial is focused on studying the effects of a treatment for Menière’s disease, a condition that affects the inner ear and can cause episodes of vertigo, which is a sensation of spinning or dizziness. The treatment being tested is an injection of methylprednisolone, a type of medication known as a corticosteroid, which is used to reduce inflammation and suppress the immune system. The trial aims to determine if methylprednisolone is more effective than a placebo in reducing the frequency of vertigo attacks in patients with Menière’s disease.

Participants in the study will receive injections directly into the ear, a method known as intratympanic injection. The study will compare the effects of methylprednisolone with those of a placebo over a period of one year. The goal is to see if the treatment can provide better control over vertigo attacks compared to not receiving the active medication. The study will also monitor the quality of life of participants, including aspects related to dizziness and tinnitus, which is a ringing or buzzing noise in one or both ears that may be associated with Menière’s disease.

In addition to methylprednisolone, the study will also consider the use of other medications such as dexamethasone, triamcinolone, and gentamicin, which are also administered through intratympanic injections. The study will track the frequency of these injections and assess their impact on hearing and overall well-being. The trial will also evaluate the use of metoclopramide, a medication that can help manage nausea and vomiting, which are common symptoms during vertigo attacks. The study is designed to provide valuable insights into the effectiveness and safety of these treatments for managing Menière’s disease.

]]>