Osteomyelitis – European Clinical Trials Information Network

Zoledronic acid versus placebo for pain relief in children with chronic recurrent multifocal osteomyelitis resistant to NSAIDs

Fri, 05 Jun 2026 10:55:56 +0000

The study focuses on Chronic recurrent multifocal osteomyelitis, a rare condition that causes recurring inflammation and pain in several bones. The investigational medication is zoledronic acid, a drug given through an IV infusion that is intended to reduce bone pain and inflammation. Children who do not get relief from standard anti‑inflammatory medicines may receive either the active drug or an inactive substance (placebo) for comparison.

The purpose of the study is to determine whether the drug improves pain levels after 12 weeks compared with placebo. Participants receive an infusion at the start of the study, then again at about 12 weeks and 24 weeks, with follow‑up visits extending to 36 weeks. At each visit, pain is recorded using simple age‑appropriate scales that involve faces or a line marked from “no pain” to “worst pain.” Whole‑body imaging with MRI (a scan that creates detailed pictures of the bones) is performed to see how many bone lesions are present. Safety checks include monitoring for flu‑like symptoms, headache, and low levels of phosphate or calcium in the blood.

Comparing local gentamicin or vancomycin hydrochloride to a drug combination for patients with diabetic foot osteomyelitis

Wed, 29 Apr 2026 15:09:54 +0000

This study investigates the treatment of Diabetic Foot Osteomyelitis, which is a serious bone infection that can occur in the feet of people with diabetes. The purpose of the study is to compare a new method of delivering medicine directly to the infected area with traditional methods of taking medicine throughout the entire body. The investigation focuses on a medical device called Stimulan Rapid Cure, which acts as a local antibiotic delivery system to provide medicine specifically at the site of the bone infection.

Participants in the study will be assigned to different groups to receive different types of treatment. One group will receive the Stimulan Rapid Cure device for local antibiotic treatment, meaning the medicine is placed directly where it is needed. The other group will receive systemic antibiotic therapy, which involves taking antibiotics—medicines used to kill bacteria—through the bloodstream via oral pills or intravenous infusions. The comparison medications used in the study include vancomycin hydrochloride, gentamicin, amoxicillin, cefuroxime, metronidazole, doxycycline, ceftriaxone sodium, levofloxacin, ciprofloxacin, clindamycin, piperacillin and tazobactam, meropenem, flucloxacillin, cefalexin, and sulfamethoxazole and trimethoprim.

Study on Treating Acute Osteomyelitis in Children with Amoxicillin and Cloxacillin Compared to Standard Hospital Care

Wed, 29 Apr 2026 14:57:45 +0000

This clinical trial focuses on children with acute osteomyelitis, a bone infection that is not severe. The study aims to compare two different treatment strategies. One strategy involves managing the condition at home with oral antibiotics, while the other involves traditional hospital care with antibiotics given through a vein, known as intravenous therapy. The main goal is to see if the home treatment is just as effective as the hospital treatment in ensuring complete recovery without the infection returning after six months.

The medications being studied include amoxicillin, cloxacillin, clavulanic acid, and cefazolin. Amoxicillin is used in two forms: as a powder for oral suspension and as an injection. Cloxacillin and cefazolin are given as injections, while clavulanic acid is taken orally as a powder mixed with liquid. These medications are all antibiotics, which are drugs used to treat infections caused by bacteria.

During the study, children will receive either the oral antibiotics at home or the intravenous antibiotics in the hospital. The study will monitor the children’s recovery over a period of six months to ensure there are no signs of the infection returning or any complications. The study will help determine if treating children with acute osteomyelitis at home is as safe and effective as the traditional hospital treatment.

Study on Early Oral Antibiotic Treatment for Vertebral Osteomyelitis Using Cefuroxime, Dicloxacillin, and Ceftriaxone for Adult Patients

Wed, 29 Apr 2026 14:25:58 +0000

This clinical trial is focused on studying the treatment of pyogenic vertebral osteomyelitis, a type of bone infection that affects the spine. The study will explore the effectiveness of switching from intravenous (IV) antibiotics to oral antibiotics after one week of IV treatment. The antibiotics being studied include cefuroxime, dicloxacillin, ceftriaxone, amoxicillin, clavulanic acid, cloxacillin, flucloxacillin, ciprofloxacin, clindamycin, vancomycin, linezolid, moxifloxacin, benzylpenicillin, ampicillin, rifampicin, phenoxymethylpenicillin, sulfamethoxazole, trimethoprim, tolu balsam, and meropenem. Some patients will receive a placebo as part of the study.

The purpose of the study is to determine if an early switch to oral antibiotics is as effective as the current standard treatment, which involves two to four weeks of IV antibiotics followed by oral antibiotics. Participants will initially receive IV antibiotics for one week. After this period, they will be randomly assigned to either continue with IV antibiotics or switch to oral antibiotics. The study will monitor the participants for any complications or relapses of the infection over a period of six months after completing the antibiotic treatment.

Throughout the study, various health indicators will be assessed, including the occurrence of any adverse events, the need for additional treatments, and the overall quality of life of the participants. The study aims to provide valuable insights into the potential benefits of transitioning to oral antibiotics earlier in the treatment process for pyogenic vertebral osteomyelitis.