Open angle glaucoma – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:16:37 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Open angle glaucoma – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on Goblet Cell Density in Patients with Ocular Hypertension or Primary Open Angle Glaucoma Using Benzalkonium Chloride and Latanoprost Eye Drops https://clinicaltrials.eu/trial/study-on-goblet-cell-density-in-patients-with-ocular-hypertension-or-primary-open-angle-glaucoma-using-benzalkonium-chloride-and-latanoprost-eye-drops/ Wed, 29 Apr 2026 15:05:29 +0000 https://clinicaltrials.eu/trial/study-on-goblet-cell-density-in-patients-with-ocular-hypertension-or-primary-open-angle-glaucoma-using-benzalkonium-chloride-and-latanoprost-eye-drops/ This clinical trial is focused on studying two eye conditions: ocular hypertension and primary open-angle glaucoma. These conditions are related to increased pressure in the eye, which can lead to vision problems if not managed properly. The study will use two types of eye drops containing the active ingredient latanoprost. One type of eye drop is called Xalatan, and the other is Monoprost, which is preservative-free. The purpose of the study is to compare the effects of these two treatments on the density of goblet cells, which are cells in the eye that help keep it moist and healthy.

Participants in the study will receive either the Xalatan or Monoprost eye drops. The study will observe changes in goblet cell density over a period of time. Additionally, the study will monitor changes in eye pressure and other factors related to eye health, such as the concentration of certain substances in the tear film and the condition of the eye’s surface. The study will also assess any changes in symptoms related to dry eye.

The trial aims to provide valuable information on how these treatments affect eye health, particularly in terms of maintaining moisture and reducing pressure in the eye. This information could help improve treatment options for people with ocular hypertension and primary open-angle glaucoma.

]]> Study on the Effects of Bimatoprost SR and Timolol in Patients with Open-angle Glaucoma or Ocular Hypertension https://clinicaltrials.eu/trial/study-on-the-effects-of-bimatoprost-sr-and-timolol-in-patients-with-open-angle-glaucoma-or-ocular-hypertension/ Wed, 29 Apr 2026 15:02:40 +0000 https://clinicaltrials.eu/trial/study-on-the-effects-of-bimatoprost-sr-and-timolol-in-patients-with-open-angle-glaucoma-or-ocular-hypertension/ This clinical trial is focused on studying the effectiveness and safety of a treatment for two eye conditions: open-angle glaucoma and ocular hypertension. These conditions can lead to increased pressure inside the eye, which may damage the optic nerve and affect vision. The treatment being tested is called Bimatoprost SR, which is an implant designed to help lower the pressure in the eye. The study will also involve the use of Timolol, an eye drop solution that is commonly used to treat high eye pressure.

The purpose of the study is to evaluate how well Bimatoprost SR can lower eye pressure and how safe it is for patients with open-angle glaucoma or ocular hypertension. Participants in the study will receive either Bimatoprost SR or a placebo, and some may also use Timolol eye drops. The study will involve initial and repeated administrations of the treatment over a period of time to monitor its effects on eye pressure.

Throughout the study, participants will have regular check-ups to measure the pressure in their eyes and to ensure their safety. The study aims to provide valuable information on the potential benefits of Bimatoprost SR for people with these eye conditions. The results could help improve treatment options for managing eye pressure and preventing vision loss in patients with open-angle glaucoma or ocular hypertension.

]]> Study Comparing Bimatoprost Eye Drops with Lumigan for Patients with Chronic Open-Angle Glaucoma or Ocular Hypertension https://clinicaltrials.eu/trial/study-comparing-bimatoprost-eye-drops-with-lumigan-for-patients-with-chronic-open-angle-glaucoma-or-ocular-hypertension/ Wed, 29 Apr 2026 14:57:00 +0000 https://clinicaltrials.eu/trial/study-comparing-bimatoprost-eye-drops-with-lumigan-for-patients-with-chronic-open-angle-glaucoma-or-ocular-hypertension/ This clinical trial is focused on studying two eye conditions: Chronic Open-angle Glaucoma and Ocular Hypertension. These conditions involve increased pressure in the eye, which can lead to vision problems if not managed properly. The study will compare two treatments: a preservative-free version of Bimatoprost eye drops, known by the code name BIM-001, and a reference product called Lumigan, which also contains Bimatoprost. Both treatments are designed to help lower the pressure inside the eye.

The purpose of this study is to evaluate how effective, safe, and tolerable these treatments are for patients with the mentioned eye conditions. Participants will be randomly assigned to one of the two treatment groups. The study will last for a period of 42 days, during which participants will use the eye drops as directed. Throughout the study, the pressure in the eyes will be monitored, and any side effects or changes in eye health will be recorded.

Participants will visit the study center several times to have their eye pressure checked and to discuss any changes in their condition. The study aims to determine which treatment is more effective in reducing eye pressure and how well patients tolerate each treatment. This information will help doctors make better treatment decisions for people with Chronic Open-angle Glaucoma or Ocular Hypertension.

]]> Study Comparing Brimonidine and Timolol Eye Drops for Patients with Open-Angle Glaucoma or Ocular Hypertension https://clinicaltrials.eu/trial/study-comparing-brimonidine-and-timolol-eye-drops-for-patients-with-open-angle-glaucoma-or-ocular-hypertension/ Wed, 29 Apr 2026 14:47:00 +0000 https://clinicaltrials.eu/trial/study-comparing-brimonidine-and-timolol-eye-drops-for-patients-with-open-angle-glaucoma-or-ocular-hypertension/ This clinical trial is focused on studying two eye conditions: open-angle glaucoma and ocular hypertension. Open-angle glaucoma is a condition where increased pressure inside the eye can lead to changes in the optic nerve and vision loss. Ocular hypertension refers to higher-than-normal pressure in the eye, which can also lead to glaucoma if not managed. The study will compare two treatments: a new generic formulation of eye drops containing brimonidine and timolol, and a marketed eye drop solution known as Combigan. Both treatments are designed to help lower the pressure inside the eye.

The purpose of the study is to determine if the new generic eye drops are as effective and well-tolerated as Combigan in patients with open-angle glaucoma or ocular hypertension. Participants in the study will use one of the two eye drop solutions over a period of 12 weeks. The study will monitor changes in eye pressure at different times of the day to assess the effectiveness of the treatments.

Throughout the study, participants will have regular check-ups to measure the pressure in their eyes and ensure the treatment is working as intended. The study aims to provide valuable information on whether the new generic eye drops can be a suitable alternative to Combigan for managing eye pressure in patients with these conditions.

]]> Study on Glaucoma Treatment: Comparing Brimonidine, Pilocarpine Nitrate, and Brinzolamide in Patients with Newly Diagnosed Open-Angle Glaucoma https://clinicaltrials.eu/trial/study-on-glaucoma-treatment-comparing-brimonidine-pilocarpine-nitrate-and-brinzolamide-in-patients-with-newly-diagnosed-open-angle-glaucoma/ Wed, 29 Apr 2026 14:29:22 +0000 https://clinicaltrials.eu/trial/study-on-glaucoma-treatment-comparing-brimonidine-pilocarpine-nitrate-and-brinzolamide-in-patients-with-newly-diagnosed-open-angle-glaucoma/ This clinical trial is focused on studying the progression of glaucoma, specifically open-angle glaucoma and PEX glaucoma. Glaucoma is a condition that affects the eyes and can lead to vision loss due to damage to the optic nerve. The study aims to compare two different treatment approaches for patients who have been newly diagnosed with this condition. The treatments being tested include a single medication approach and a combination of medications, which may include additional treatments like laser therapy. The medications involved in this study are brimonidine, pilocarpine nitrate, brinzolamide, timolol maleate, latanoprost, betaxolol, bimatoprost, dorzolamide hydrochloride, travoprost, and tafluprost. Some of these medications may be used in combination to enhance their effectiveness.

The purpose of the study is to observe and compare how quickly the disease progresses in patients receiving different types of treatment. Participants will be randomly assigned to either the intensive treatment group or the conventional treatment group. The study will monitor the rate of vision loss and any changes in the condition over time. This will help determine which treatment approach is more effective in slowing down the progression of glaucoma. The study will also consider the quality of life of the participants and how well they adhere to the treatment plan.

Participants in the study will receive treatment for a period of up to 120 days, with regular follow-ups to assess their condition. The study will continue to collect data on the participants’ eye health and vision changes. This information will be used to better understand the effectiveness of the treatments and to improve future care for individuals with glaucoma. The study is expected to conclude by the end of 2027.

]]> Study on the Effectiveness of Bimatoprost SR for Patients with Open-Angle Glaucoma or Ocular Hypertension https://clinicaltrials.eu/trial/study-on-the-effectiveness-of-bimatoprost-sr-for-patients-with-open-angle-glaucoma-or-ocular-hypertension/ Wed, 29 Apr 2026 14:27:05 +0000 https://clinicaltrials.eu/trial/study-on-the-effectiveness-of-bimatoprost-sr-for-patients-with-open-angle-glaucoma-or-ocular-hypertension/ This clinical trial is focused on studying the effects of a treatment called Bimatoprost SR for individuals with Open-Angle Glaucoma or Ocular Hypertension. These are eye conditions that can lead to increased pressure inside the eye, potentially causing vision problems. The treatment involves using an implant that releases the medication over time to help lower the pressure in the eye.

The purpose of the study is to evaluate how long the pressure-lowering effect of Bimatoprost SR lasts in participants who have not been able to manage their eye pressure effectively with regular eye drops, possibly due to side effects or difficulty in using the drops consistently. Participants will receive the implant, and their eye health will be monitored over a period of time to assess the duration of the treatment’s effectiveness.

Throughout the study, participants will undergo various eye examinations to ensure their safety and to gather information on how the treatment is working. These examinations may include checking the visual fields, measuring visual acuity, and performing detailed eye assessments using specialized equipment. The study aims to provide valuable insights into the potential benefits of Bimatoprost SR for managing eye pressure in individuals with these conditions.

]]> Study on Long-term Safety and Effectiveness of Bimatoprost SR for Patients with Open-angle Glaucoma or Ocular Hypertension https://clinicaltrials.eu/trial/study-on-long-term-safety-and-effectiveness-of-bimatoprost-sr-for-patients-with-open-angle-glaucoma-or-ocular-hypertension/ Wed, 29 Apr 2026 14:26:00 +0000 https://clinicaltrials.eu/trial/study-on-long-term-safety-and-effectiveness-of-bimatoprost-sr-for-patients-with-open-angle-glaucoma-or-ocular-hypertension/ This clinical trial is focused on studying the long-term safety and effectiveness of a treatment called Bimatoprost SR for patients with Open-angle Glaucoma or Ocular Hypertension. These are eye conditions that can lead to increased pressure inside the eye, potentially causing damage to the optic nerve and affecting vision. The treatment being tested is an implant that releases the medication Bimatoprost over time to help lower the pressure in the eye.

The purpose of the study is to evaluate how safe Bimatoprost SR is for patients and how long it can effectively reduce eye pressure. Participants in the study will receive the implant and be monitored over a period to assess the treatment’s impact on their eye health. The study will involve regular check-ups to observe any changes in vision and eye pressure, as well as to ensure the treatment is working as intended.

Throughout the study, participants will be observed for any side effects or changes in their eye condition. The study aims to provide valuable information on the long-term use of Bimatoprost SR for managing Open-angle Glaucoma and Ocular Hypertension, helping to determine its potential as a reliable treatment option for these conditions.

]]> Study on the Effectiveness of Citicoline Eye Drops for Visual Field Preservation in Patients with Open Angle Glaucoma https://clinicaltrials.eu/trial/study-on-the-effectiveness-of-citicoline-eye-drops-for-visual-field-preservation-in-patients-with-open-angle-glaucoma/ Wed, 29 Apr 2026 14:23:53 +0000 https://clinicaltrials.eu/trial/study-on-the-effectiveness-of-citicoline-eye-drops-for-visual-field-preservation-in-patients-with-open-angle-glaucoma/ This clinical trial is focused on studying the effects of a treatment for glaucoma, a condition that affects the eyes and can lead to vision loss. The treatment being tested is citicoline eye drops, which are being compared to placebo eye drops. The main goal of the study is to determine if citicoline eye drops can better preserve the visual field, which is the area a person can see, in patients with open-angle glaucoma, a common type of glaucoma where the drainage angle for eye fluid remains open.

Participants in the study will receive either the citicoline eye drops or placebo eye drops. The study will last for a period of three years, during which the participants’ eye health and vision will be monitored regularly. The study aims to see if there is a difference in how the vision changes over time between those using citicoline and those using placebo. The researchers will also look at changes in the thickness of certain layers of the retina, the light-sensitive tissue at the back of the eye, using a method called Optical Coherence Tomography (OCT).

This study is important for understanding whether citicoline eye drops can help slow down the progression of vision loss in people with open-angle glaucoma. By comparing the effects of citicoline to placebo, researchers hope to find a more effective way to manage this eye condition and improve the quality of life for those affected by it.

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