Oesophageal achalasia – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Thu, 28 May 2026 11:28:26 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Oesophageal achalasia – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study of citalopram effectiveness in reducing chest pain for adults with achalasia https://clinicaltrials.eu/trial/study-on-the-effect-of-citalopram-on-chest-pain-in-patients-with-achalasia/ Wed, 29 Apr 2026 15:05:51 +0000 https://clinicaltrials.eu/trial/study-on-the-effect-of-citalopram-on-chest-pain-in-patients-with-achalasia/ Achalasia is a condition where the muscles of the lower esophagus (food pipe) do not relax properly, making it difficult to swallow food and causing chest pain. This study focuses on testing citalopram, a medication typically used for depression, to see if it can help reduce chest pain in people who have already received treatment for achalasia but still experience pain.

The study will compare citalopram tablets with a placebo to determine if the medication is effective in reducing chest pain episodes in achalasia patients. Each participant will receive either a 20-milligram citalopram tablet or a placebo tablet to take daily for 6 weeks.

Throughout the study, participants will keep track of their symptoms and complete various questionnaires about their pain levels and overall well-being. The researchers will monitor how the medication affects chest pain relief and any potential side effects that may occur during the treatment period.

]]> Study on Lansoprazole for Preventing Acid Reflux in Patients with Esophageal Achalasia After Endoscopic Myotomy https://clinicaltrials.eu/trial/study-on-lansoprazole-for-preventing-acid-reflux-in-patients-with-esophageal-achalasia-after-endoscopic-myotomy/ Wed, 29 Apr 2026 14:24:46 +0000 https://clinicaltrials.eu/trial/study-on-lansoprazole-for-preventing-acid-reflux-in-patients-with-esophageal-achalasia-after-endoscopic-myotomy/ This clinical trial focuses on a condition called esophageal achalasia, which affects the ability of the esophagus to move food toward the stomach. The study is examining the use of a medication called Lansoprazole, which is taken as orodispersible tablets, meaning they dissolve in the mouth. The purpose of the study is to evaluate whether taking Lansoprazole regularly for 12 months is more effective in preventing acid reflux compared to taking it only when symptoms appear, after a procedure known as POEM (Peroral Endoscopic Myotomy) for treating esophageal achalasia.

Participants in the study will be randomly assigned to one of two groups. One group will receive routine treatment with Lansoprazole for a year, while the other group will take the medication only if they experience symptoms of acid reflux. The study will monitor the presence of acid reflux at 6 months and again at 12 months. This will help determine the effectiveness of the treatment in preventing acid reflux, which can cause discomfort and other complications.

Throughout the study, various aspects will be assessed, including the quality of life of participants, the amount of Lansoprazole consumed, and any adverse reactions. Additionally, the study will evaluate the presence of esophagitis, a condition where the esophagus becomes inflamed, and other related symptoms. The trial aims to provide valuable insights into the best approach for managing acid reflux in patients who have undergone the POEM procedure for esophageal achalasia.

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