Nicotine dependence – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:23:23 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Nicotine dependence – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 A study to evaluate how cytisinicline works in patients with nicotine addiction and kidney problems or those undergoing dialysis https://clinicaltrials.eu/trial/a-study-to-evaluate-how-cytisinicline-works-in-patients-with-nicotine-addiction-and-kidney-problems-or-those-undergoing-dialysis/ Thu, 30 Apr 2026 13:08:49 +0000 https://clinicaltrials.eu/trial/a-study-to-evaluate-how-cytisinicline-works-in-patients-with-nicotine-addiction-and-kidney-problems-or-those-undergoing-dialysis/ This study focuses on individuals with nicotine addiction, a condition characterized by a physical and psychological dependence on nicotine. The research involves the use of a medication called cytisinicline, which is administered as a 3 mg oral film coated tablet. The purpose of the study is to investigate how renal impairment, which refers to a decreased ability of the kidneys to filter waste from the blood, and dialysis, a medical process that cleans the blood when kidneys cannot function properly, affect how the body processes this drug.

During the study, the way the body absorbs, distributes, and removes the medication will be examined. This process is known as pharmacokinetics. Researchers will look at how much of the drug remains in the blood and how much is removed through urine or during the blood cleaning process. The study will also monitor safety by observing vital signs and conducting various clinical tests.

]]> Study of cytisinicline and moxifloxacin effects on heart electrical activity in healthy smokers with nicotine addiction https://clinicaltrials.eu/trial/study-of-cytisinicline-and-moxifloxacin-effects-on-heart-electrical-activity-in-healthy-smokers-with-nicotine-addiction/ Wed, 29 Apr 2026 15:07:14 +0000 https://clinicaltrials.eu/trial/study-of-cytisinicline-and-moxifloxacin-effects-on-heart-electrical-activity-in-healthy-smokers-with-nicotine-addiction/ This study examines the effects of cytisinicline, a medication being tested for nicotine addiction. The research compares cytisinicline with moxifloxacin and placebo to understand how the medication affects heart function in people who smoke. The study focuses specifically on evaluating the heart’s electrical activity in healthy smokers.

The study involves taking film-coated tablets of cytisinicline at different dose levels to see how the medication affects the heart’s rhythm. During the study, participants receive different treatments across four separate periods. The treatments include cytisinicline at regular and higher doses, moxifloxacin, and placebo. The medication is taken by mouth.

The main purpose is to check if cytisinicline causes any changes in the heart’s electrical patterns compared to when taking no medication. This is important to ensure the safety of the medication for people trying to quit smoking. The study measures various aspects of heart activity through electrocardiogram recordings, which are tests that show how the heart is beating.

]]> Study Comparing Cytisinicline and Nicotine Therapy for Patients with Nicotine Dependence and Chronic Kidney Disease https://clinicaltrials.eu/trial/study-comparing-cytisinicline-and-nicotine-therapy-for-patients-with-nicotine-dependence-and-chronic-kidney-disease/ Wed, 29 Apr 2026 14:47:37 +0000 https://clinicaltrials.eu/trial/study-comparing-cytisinicline-and-nicotine-therapy-for-patients-with-nicotine-dependence-and-chronic-kidney-disease-2/ This clinical trial is focused on helping people who are dependent on nicotine and also have Chronic Kidney Disease. The study will compare two treatments: a medication called Cytisine, which will be given in a prolonged dosage, and various forms of Nicotine Replacement Therapy (NRT). NRT includes products like Nicorette Invisipatch (a transdermal patch) and Nicorette Fruit and Coolmint lozenges, which are designed to help reduce nicotine cravings.

The purpose of the study is to assess and compare the effectiveness of these treatments over a period of six months. Participants will be randomly assigned to either the Cytisine group or the NRT group. The study will last for 12 weeks, during which participants will receive their assigned treatment. Throughout the study, participants will be monitored for their ability to abstain from smoking, as well as any withdrawal symptoms or side effects they may experience.

Participants will be asked to attend regular check-ups to evaluate their progress and any changes in their health. The goal is to determine whether Cytisine is as effective as NRT in helping people quit smoking, especially those with Chronic Kidney Disease. This study aims to provide valuable insights into the best ways to support individuals in overcoming nicotine dependence while managing their kidney health.

]]> Study on Nicotine Freshmint Mouthspray for E-cigarette Users Looking to Quit https://clinicaltrials.eu/trial/study-on-nicotine-freshmint-mouthspray-for-e-cigarette-users-looking-to-quit/ Wed, 29 Apr 2026 14:25:30 +0000 https://clinicaltrials.eu/trial/study-on-nicotine-freshmint-mouthspray-for-e-cigarette-users-looking-to-quit/ This clinical trial is focused on helping people who use e-cigarettes and want to quit. The study will test a treatment called Nicotine Freshmint Mouthspray, which is a spray used in the mouth that contains nicotine. The trial will compare this spray to a similar spray that looks the same but does not contain nicotine, known as a placebo. The main goal of the study is to see how effective the Nicotine Freshmint Mouthspray is in helping people stop using e-cigarettes.

Participants in the study will be randomly assigned to use either the Nicotine Freshmint Mouthspray or the placebo. The study will last for several weeks, during which participants will visit the clinic at different times to check their progress. These visits will help researchers understand how well the spray works and if there are any side effects. Participants will be asked to report if they have stopped using e-cigarettes and if they have any cravings or withdrawal symptoms.

The study will also monitor the safety of the Nicotine Freshmint Mouthspray by collecting information on any adverse events reported by participants. This information will help determine if the spray is safe to use. The trial aims to provide valuable insights into whether the Nicotine Freshmint Mouthspray can be an effective aid for people looking to quit e-cigarettes.

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