Neuromuscular blockade – European Clinical Trials Information Network

Study on Muscle Relaxation Reappearance in Patients Under General Anesthesia Using Glycopyrronium Bromide and Neostigmine Methylsulfate

Wed, 29 Apr 2026 14:59:22 +0000

This clinical trial is focused on understanding the effects of a medication called Glycostigmin, which is a solution for injection containing two active substances: glycopyrronium bromide and neostigmine methylsulfate. The study is particularly interested in how these substances work together to reverse muscle relaxation during general anesthesia. Muscle relaxation is often used during surgeries to help keep the body still, and reversing this relaxation is important for recovery after the procedure.

The main purpose of the study is to find out how often muscle relaxation returns after it has been reversed with neostigmine. This is important because sometimes, even after the medication is given to reverse the muscle relaxation, the muscles might not fully regain their normal function right away. The study will monitor patients who are undergoing general anesthesia to see how their muscles respond after receiving the reversal medication.

Participants in the study will receive the medication through an intravenous infusion, which means it will be delivered directly into the bloodstream. The study will observe the effects of the medication over a short period to gather information on how well it works in preventing the reappearance of muscle relaxation. This research aims to improve the safety and effectiveness of reversing muscle relaxation during surgeries.

Study on the Effectiveness of Dexmedetomidine, Ropivacaine, and Dexamethasone for Pain Relief in Patients Undergoing Shoulder Surgery

Wed, 29 Apr 2026 14:26:13 +0000

This clinical trial is focused on patients who are scheduled for shoulder surgeries. The study aims to find the most effective dose of dexmedetomidine when used alongside ropivacaine for a type of anesthesia called an interscalene plexus block. This block is used to numb the shoulder area during surgery. The trial will also involve the use of dexamethasone, which will be given intravenously, meaning it will be administered directly into a vein.

The purpose of the study is to determine how different doses of dexmedetomidine can extend the duration of pain relief after the anesthesia block. Participants will receive either the study medication or a placebo. The trial will monitor various outcomes, such as how long the pain relief lasts, the duration of numbness and muscle weakness, and any side effects like nausea or changes in heart rate and blood pressure. The study will also assess the amount of pain medication needed after surgery and the time it takes for patients to recover from anesthesia.

Participants will be randomly assigned to different groups, and neither the participants nor the researchers will know who is receiving which treatment. This is known as a double-blind study. The trial is expected to run until June 2025, with recruitment having started in September 2023. The findings from this study could help improve pain management for patients undergoing shoulder surgery.