Neonatal respiratory failure – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:15:21 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Neonatal respiratory failure – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on Persistent Pulmonary Hypertension in Newborns Treated with Salbutamol and Sodium Chloride https://clinicaltrials.eu/trial/study-on-persistent-pulmonary-hypertension-in-newborns-treated-with-salbutamol-and-sodium-chloride/ Wed, 29 Apr 2026 15:04:07 +0000 https://clinicaltrials.eu/trial/study-on-persistent-pulmonary-hypertension-in-newborns-treated-with-salbutamol-and-sodium-chloride/ This clinical trial is focused on studying a condition known as persistent pulmonary hypertension of the newborn (PPHN), which affects the breathing of newborns. The study involves the use of a medication called salbutamol, which is commonly used to help with breathing issues. Salbutamol is administered through inhalation, meaning it is breathed in to help open up the airways in the lungs.

The purpose of the study is to evaluate how often PPHN occurs in newborns who are treated with salbutamol. The study will observe newborns who are born between 32 and 42 weeks of pregnancy and have breathing problems shortly after birth. These newborns may need help with breathing, such as ventilation, which is a method to assist with breathing using a machine. The study will monitor the newborns’ breathing and other health indicators over a period of time to gather information on the effectiveness of salbutamol in treating PPHN.

During the study, researchers will assess various factors, including the need for additional oxygen, the duration of respiratory support, and the overall hospital stay. They will also look at the results of certain tests, such as the acid-base balance, which measures the levels of acids and bases in the blood, and the occurrence of any adverse events. The study aims to provide valuable insights into the treatment of PPHN in newborns using salbutamol.

]]> Study on the Effect of Caffeine Citrate for Patients with Extubation Failure and Bronchopulmonary Dysplasia https://clinicaltrials.eu/trial/study-on-the-effect-of-caffeine-citrate-for-patients-with-extubation-failure-and-bronchopulmonary-dysplasia/ Wed, 29 Apr 2026 15:03:19 +0000 https://clinicaltrials.eu/trial/study-on-the-effect-of-caffeine-citrate-for-patients-with-extubation-failure-and-bronchopulmonary-dysplasia/ This clinical trial is focused on studying the effects of an additional dose of caffeine citrate in preterm newborns who are at risk of extubation failure and bronchopulmonary dysplasia. Extubation failure occurs when a baby has difficulty breathing on their own after being taken off a breathing machine, while bronchopulmonary dysplasia is a lung condition that can affect premature infants. The treatment being tested is a solution of caffeine citrate, which is given through an injection to help stimulate breathing.

The purpose of the study is to see if giving an extra dose of caffeine citrate before removing the breathing tube can improve the chances of successful extubation. The study will monitor the need for reintubation, which means putting the breathing tube back in if the baby struggles to breathe on their own. It will also look at other factors like the frequency of breathing pauses (apneas), side effects such as increased heart rate or blood pressure, and any digestive issues. Additionally, the study will observe the development of conditions like necrotizing enterocolitis, a serious intestinal disease, and the progression of brain-related issues such as intraventricular hemorrhage or periventricular leukomalacia.

The trial will follow the participants over a period to assess their neurodevelopmental outcome, which refers to how well their brain develops and functions over time. The study aims to provide valuable insights into whether this additional caffeine citrate dose can help improve breathing outcomes and overall health in these vulnerable infants.

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