Neoadjuvant therapy – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:18:16 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Neoadjuvant therapy – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study of inavolisib, letrozole and ribociclib in untreated early-stage breast cancer patients with PIK3CA mutation https://clinicaltrials.eu/trial/study-of-inavolisib-letrozole-and-ribociclib-in-untreated-early-stage-breast-cancer-patients-with-pik3ca-mutation/ Wed, 29 Apr 2026 15:06:38 +0000 https://clinicaltrials.eu/trial/study-of-inavolisib-letrozole-and-ribociclib-in-untreated-early-stage-breast-cancer-patients-with-pik3ca-mutation/ This clinical trial focuses on patients with early-stage breast cancer that has a specific genetic change called PIK3CA mutation. The cancer type being studied is also characterized as being estrogen receptor-positive and HER2-negative, which refers to specific features of the tumor cells that help determine the most appropriate treatment approach.

The study will test a new drug called inavolisib (also known as GDC-0077) in combination with other medications including letrozole and ribociclib. These medications are given as tablets that patients take by mouth. The treatment is given before surgery, which is known as neoadjuvant treatment, to see if it can help shrink the tumor.

The main purpose of this study is to understand how safe these drug combinations are and how well patients can tolerate them. During the study, patients will receive treatment for up to 6 months. Doctors will monitor patients’ health through regular check-ups and laboratory tests. They will also examine how well the treatment works by measuring changes in the tumor and checking for any side effects that patients may experience.

]]> Study of CAPOX or FOLFOX chemotherapy before surgery in patients with obstructive colon cancer treated with colostomy https://clinicaltrials.eu/trial/study-on-neoadjuvant-chemotherapy-with-capecitabine-oxaliplatin-and-fluorouracil-for-patients-with-obstructive-colon-cancer-treated-by-colostomy/ Wed, 29 Apr 2026 14:58:58 +0000 https://clinicaltrials.eu/trial/study-on-neoadjuvant-chemotherapy-with-capecitabine-oxaliplatin-and-fluorouracil-for-patients-with-obstructive-colon-cancer-treated-by-colostomy/ This clinical trial focuses on treating patients with obstructive colon cancer who have undergone initial treatment with a temporary opening in the abdomen (stoma) to relieve the blockage. The study aims to determine if giving chemotherapy before surgery can improve treatment outcomes compared to giving chemotherapy after surgery.

The treatment involves different combinations of chemotherapy medications including oxaliplatin, fluorouracil, capecitabine, and levoleucovorin. These medications are given either as tablets taken by mouth or as solutions administered through a vein. The chemotherapy combinations used in this study are known as CAPOX and FOLFOX.

The treatment period lasts up to 6 months, during which patients receive regular doses of chemotherapy medications. Throughout the study, patients will need to undergo various medical examinations and tests to monitor their health and response to treatment. The success of the treatment will be measured by how many patients can complete the entire planned treatment sequence.

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