Mitral valve disease – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 11:22:28 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Mitral valve disease – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study of SP16 to Prevent Acute Kidney Injury in Patients with Chronic Kidney Disease Undergoing Heart Surgery with Heart-Lung Machine https://clinicaltrials.eu/trial/study-of-sp16-to-prevent-acute-kidney-injury-in-patients-with-chronic-kidney-disease-undergoing-heart-surgery-with-heart-lung-machine/ Wed, 29 Apr 2026 15:08:15 +0000 https://clinicaltrials.eu/trial/study-of-sp16-to-prevent-acute-kidney-injury-in-patients-with-chronic-kidney-disease-undergoing-heart-surgery-with-heart-lung-machine/ This clinical trial is studying people who have Chronic Kidney Disease along with heart valve problems or other Cardiovascular Disease who need planned heart surgery. The study will test a treatment called SP16, which is an anti-inflammatory medication given as an injection under the skin. Some participants will receive SP16 while others will receive placebo. The purpose of the study is to evaluate the safety of SP16 and to see if it can prevent a serious complication called Acute Kidney Injury that can occur after heart surgery in people with existing kidney disease. During the surgery, a heart-lung-machine, also called cardiopulmonary bypass, will be used to temporarily take over the work of the heart and lungs.

The study will involve people with chronic kidney disease who are scheduled for heart surgery such as coronary artery bypass grafting (a procedure to improve blood flow to the heart), aortic valve surgery (repair or replacement of the valve between the heart and the main artery), mitral valve surgery (repair or replacement of the valve between the upper and lower chambers on the left side of the heart), or a combination of these procedures. Participants will receive the study medication or placebo before their surgery. After the surgery, they will be carefully monitored in the hospital to check their kidney function by measuring substances in their blood and urine. The medical team will watch for any side effects or complications, particularly during the first 72 hours after surgery.

The observation period will continue for about 90 days after the surgery. During this time, participants will have follow-up visits where doctors will check their kidney function, heart function using ultrasound imaging of the heart called echocardiography, and measure specific markers in the blood such as NT-proBNP, which indicates how well the heart is working. The study will track whether participants develop kidney injury after surgery, how severe it becomes, how long it takes for kidney function to return to normal, and whether any participants need dialysis, which is a treatment that filters the blood when the kidneys cannot do so properly. The medical team will also monitor oxygen levels in the blood and record any adverse events or serious health problems that occur throughout the study period.

]]> Study on the Effects of Oxycodone and Paracetamol in Patients with Heart Valve or Coronary Artery Disease After Cardiac Surgery https://clinicaltrials.eu/trial/study-on-the-effects-of-oxycodone-and-paracetamol-in-patients-with-heart-valve-or-coronary-artery-disease-after-cardiac-surgery/ Wed, 29 Apr 2026 14:58:58 +0000 https://clinicaltrials.eu/trial/study-on-the-effects-of-oxycodone-and-paracetamol-in-patients-with-heart-valve-or-coronary-artery-disease-after-cardiac-surgery/ This clinical trial is focused on patients who have undergone heart surgery, specifically those with conditions like coronary artery disease, aortic valve disease, mitral valve disease, tricuspid valve disease, or a combination of these. The study is investigating the effects of a medication called oxycodone, which is used for pain relief. Oxycodone will be administered through a method called PCA, or patient-controlled analgesia, which allows patients to manage their pain by controlling the amount of medication they receive.

The purpose of the study is to evaluate how oxycodone affects breathing after heart surgery. Researchers will monitor patients’ oxygen levels and breathing patterns to understand any changes that occur with the use of oxycodone. The study will also look at how much oxycodone is used and its concentration in the blood. Additionally, the study will assess pain levels, any complications from surgery, and overall quality of life after the surgery.

Participants in the study will receive either oxycodone or a placebo. The study will take place over a period of time, with regular check-ins to monitor the effects of the medication. The goal is to gather information on both the short-term and long-term outcomes of using oxycodone for pain management after heart surgery.

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