Metastases to biliary tract – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Fri, 12 Jun 2026 10:31:44 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Metastases to biliary tract – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study of AZD9574 and Temozolomide for Patients with Advanced Solid Tumors, Including Breast, Ovarian, Pancreatic, and Prostate Cancers https://clinicaltrials.eu/trial/study-of-azd9574-and-temozolomide-for-patients-with-advanced-solid-tumors-including-breast-ovarian-pancreatic-and-prostate-cancers/ Wed, 29 Apr 2026 14:28:05 +0000 https://clinicaltrials.eu/trial/study-of-azd9574-and-temozolomide-for-patients-with-advanced-solid-tumors-including-breast-ovarian-pancreatic-and-prostate-cancers/ This clinical trial is focused on studying the effects of a new treatment for patients with advanced solid tumors. The study involves a medication called AZD9574, which is being tested both on its own and in combination with other anti-cancer treatments. The diseases being studied include IDH-mutant glioma, a type of brain tumor, and various advanced or relapsed cancers such as HER2-negative breast cancer, ovarian cancer, prostate cancer, and pancreatic cancer. These cancers may have specific genetic mutations like BRCA1, BRCA2, PALB2, RAD51C, or RAD51D.

The purpose of the study is to assess the safety and tolerability of AZD9574 in patients with these advanced cancers. Participants will receive the medication in the form of a film-coated tablet taken orally. The study will monitor how the body processes the drug, its effects on the cancer, and any side effects that may occur. Some participants may receive a placebo for comparison. The study will also explore how the drug affects specific biomarkers, which are indicators of how the body is responding to the treatment.

Throughout the study, participants will undergo regular health checks, including blood tests and imaging scans, to track their progress and the impact of the treatment. The study aims to gather information over a period of time to determine the potential benefits and risks of AZD9574 for treating these types of cancers. This research is important for developing new treatment options for patients with advanced solid tumors.

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