Metabolic surgery – European Clinical Trials Information Network https://clinicaltrials.eu Bridging Patients with Clinical Trials Thu, 28 May 2026 11:28:26 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://clinicaltrials.eu/wp-content/uploads/2024/12/cropped-EU_icon-32x32.png Metabolic surgery – European Clinical Trials Information Network https://clinicaltrials.eu 32 32 Study on Morphine, Lidocaine, and Naloxone for Patients with Obesity and Sleep Apnea https://clinicaltrials.eu/trial/study-on-morphine-lidocaine-and-naloxone-for-patients-with-obesity-and-sleep-apnea/ Wed, 29 Apr 2026 15:05:51 +0000 https://clinicaltrials.eu/trial/study-on-morphine-lidocaine-and-naloxone-for-patients-with-obesity-and-sleep-apnea/ This clinical trial is focused on understanding how the body processes and responds to morphine hydrochloride, a medication commonly used for pain relief, in individuals who are healthy as well as those with obesity and obstructive sleep apnea. The study aims to gather important information about the safety and effectiveness of morphine, especially for patients undergoing surgery who have these conditions. By doing so, the study hopes to improve pain management strategies, ensuring effective pain relief with minimal side effects.

Participants in the study will receive morphine, and researchers will observe how it is absorbed and how it affects the body. The study will also involve the use of naloxone hydrochloride, an antidote for morphine, and lidocaine hydrochloride, a local anesthetic, to better understand their roles in managing pain and potential side effects. The study will take place over a short period, with participants receiving these medications through injections.

The goal is to develop a more personalized approach to treating pain, particularly for those with obesity and sleep apnea, by understanding how these conditions affect the way morphine works in the body. This research could lead to better pain management practices for surgical patients, especially those undergoing weight-loss surgery. The study is expected to provide valuable insights that could benefit future patients by tailoring pain relief methods to individual needs.

]]> Study on Bupropion Hydrochloride and Naltrexone Hydrochloride for Patients with Weight Regain After Bariatric Surgery https://clinicaltrials.eu/trial/study-on-bupropion-hydrochloride-and-naltrexone-hydrochloride-for-patients-with-weight-regain-after-bariatric-surgery/ Wed, 29 Apr 2026 15:02:58 +0000 https://clinicaltrials.eu/trial/study-on-bupropion-hydrochloride-and-naltrexone-hydrochloride-for-patients-with-weight-regain-after-bariatric-surgery/ This clinical trial is focused on patients who have experienced weight regain after undergoing Obesity Surgery, specifically procedures like Roux-en-Y gastric bypass or Gastric Sleeve surgery. The study is investigating the effects of a medication called Mysimba, which is a combination of two active substances: Bupropion Hydrochloride and Naltrexone Hydrochloride. These substances are used in the form of prolonged-release tablets, which means they release the medication slowly over time.

The purpose of the study is to understand how effective Mysimba is in helping patients lose weight after they have regained it following their surgery. The study will compare the weight loss results of patients taking Mysimba with those who are not, over a period of 22 weeks. The goal is to see if patients taking Mysimba can achieve a weight loss of more than 5% compared to those who do not take the medication.

Participants in the study will take the medication orally, and their progress will be monitored to assess the impact of the treatment. The study aims to provide insights into the dose response of Mysimba in patients who have had weight loss surgery and are experiencing weight regain. This research could help improve treatment options for individuals struggling with Obesity after surgery.

]]> Study on Tranexamic Acid and Sodium Chloride to Reduce Bleeding in Gastric Bypass Surgery for Patients with Severe Obesity https://clinicaltrials.eu/trial/study-on-tranexamic-acid-and-sodium-chloride-to-reduce-bleeding-in-gastric-bypass-surgery-for-patients-with-severe-obesity/ Wed, 29 Apr 2026 14:29:07 +0000 https://clinicaltrials.eu/trial/study-on-tranexamic-acid-and-sodium-chloride-to-reduce-bleeding-in-gastric-bypass-surgery-for-patients-with-severe-obesity/ This clinical trial is focused on studying the effects of a medication called tranexamic acid in patients with morbid obesity who are undergoing a type of weight-loss surgery known as gastric bypass. Morbid obesity is a condition where a person has an excessive amount of body fat, which can lead to various health problems. The purpose of the study is to see if using tranexamic acid during the surgery can help reduce bleeding. Tranexamic acid is given as a solution through a vein, which is known as intravenous use.

In this study, some patients will receive tranexamic acid, while others will receive a placebo, which is a substance with no active medication. Another substance used in the study is sodium chloride, which is a common salt solution often used in medical settings. The study will compare the outcomes of those who receive tranexamic acid with those who receive the placebo to determine if there is a difference in the amount of bleeding during and after the surgery.

The study will follow patients through their surgery and recovery to monitor for any bleeding complications and other related outcomes. This includes checking for any need for additional medical interventions due to bleeding, as well as observing any side effects from the medication. The goal is to gather information that could help improve the safety and effectiveness of gastric bypass surgery for patients with morbid obesity.

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